|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Non-alcoholic fatty liver disease and diabetes: From physiopathological interplay to diagnosis and treatment显示文摘Non-alcoholic fatty liver disease(NAFLD)is highly prevalent in patients with diabetes mellitus and increasing evidence suggests that patients with type 2diabetes are at a particularly high risk for developing the progressive forms of NAFLD,non-alcoholic steatohepatitis and associated advanced liver fibrosis.Moreover,diabetes is an independent risk factor for NAFLD progression,and for hepatocellular carcinoma development and liver-related mortality in prospective studies.Notwithstanding,patients with NAFLD have an elevated prevalence of prediabetes.Recent studies have shown that NAFLD presence predicts the development of type2 diabetes.Diabetes and NAFLD have mutual pathogenetic mechanisms and it is possible that genetic and environmental factors interact with metabolic derangements to accelerate NAFLD progression in diabetic patients.The diagnosis of the more advanced stages of NAFLD in diabetic patients shares the same challenges as in non-diabetic patients and it includes imaging and serological methods,although histopathological evaluation is still considered the gold standard diagnostic method.An effective established treatment is not yet available for patients with steatohepatitis and fibrosis and randomized clinical trials including only diabetic patients are lacking.We sought to outline the published data including epidemiology,pathogenesis,diagnosis and treatment of NAFLD in diabetic patients,in order to better understand the interplay between these two prevalent diseases and identify the gaps that still need to be fulfilled in the management of NAFLD in patients with diabetes mellitus. | Nathalie C Leite Cristiane A Villela-Nogueira Claudia R L Cardoso Gil F Salles | 2014 | World Journal of Gastroenterology2014，20，26： | 21 |
| 2 | Role of bacterial and genetic factors in gastric cancer in Costa Rica显示文摘AIM: To evaluate several risk factors for gastric cancer (GC) in Costa Rican regions with contrasting GC incidence rate (GCIR). METHODS: According to GCIR, 191 Helicobacter pylori (H pylori)-positive patients were classified into groups A (high GCIR, n = 101) and B (low GCIR, n = 90). Human DNA obtained from biopsy specimens was used in the determination of polymorphisms of the genes coding for interleukin (IL)-1β and IL-10 by PCR-RFLP, and IL-1RN by PCR. H pylori DNA extractions obtained from clinical isolates of 83 patients were used for PCR-based genotyping of H pylori cagA, vacA and babA2. Human DNA from gastric biopsies of 52 GC patients was utilized for comparative purposes. RESULTS: Cytokine polymorphisms showed no association with GCIR variability. However, gastric atrophy, intestinal metaplasia and strains with different vacA genotypes in the same stomach (mixed strain infection) were more frequently found in group A than in group B, and cagA and vacA s1b were signif icantly associated with high GCIR (P = 0.026 and 0.041, respectively). IL- 1β+3954_T/C (OR 2.1, 1.0-4.3), IL-1RN*2/L (OR 3.5, 1.7-7.3) and IL-10-592_C/A (OR 3.2, 1.5-6.8) were individually associated with GC, and a combination of these cytokine polymorphisms with H pylori vacA s1b and m1 further increased the risk (OR 7.2, 1.4-36.4). CONCLUSION: Although a proinflammatory cytokine genetic profile showed an increased risk for developing GC, the characteristics of H pylori infection, in particular the status of cagA and vacA genotype distribution seemed to play a major role in GCIR variability in Costa Rica. | Sergio A Con Hiroaki Takeuchi Gil R Con-Chin Vicky G Con-Chin Nobufumi Yasuda Reinaldo Con-Wong | 2009 | World Journal of Gastroenterology2009，15，2： | 9 |
| 3 | On the use Zadeh's probabilistic definition for testing statistical hypotheses from fuzzy information显示文摘 | Casals M R Gil M A Gil P | 1986 | Fuzzy Sets and Systems1986，20，： | 4 |
| 4 | 新型钢-胶合竹组合网架的试验研究显示文摘胶合竹(Glubam)是一种新型天然纤维增强复合材料,根据已有的关于胶合竹的力学性能研究,将胶合竹材与钢材组合,采用钢夹板螺栓连接和钢填板螺栓连接,从而设计出一种新型的钢-胶合竹组合网架并进行了相关试验。试验结果表明:该新型网架具有较高的承载力,且组合节点的螺栓连接均非常可靠,最终破坏时由胶合竹斜腹杆屈曲而引起。钢-胶合竹网架结构具有用钢量少、外形美观、结构承载能力高等诸多优点,值得进一步研究与发展。 | 杨秋旺 肖岩 吴越 MALYSHEV R GIL H B | 2016 | 南京工业大学学报(自然科学版)2016，38，5： | 3 |
| 5 | A role for the scaffolding adapter Gab2 in breast cancer 显示文摘 | Bentires-Alj M Gil SG Chan R | 2006 | Nat Med2006，12，1： | 1 |
| 6 | Functional as-sessment of perforin C2 domain mutations illustrates the critical role for calcium-dependent lipid binding in perforin cytotoxic func- tion显示文摘 | Urrea Moreno R Gil J Rodriguez-Sainz C | 2009 | Blood2009，113，2： | 1 |
| 7 | The dual PI3K/ mTOR inhibitor PI-103 promotes immunosuppression, in vivo tumor growth and increases survival of so rafenib- treated melanoma cells 显示文摘 | Lopez-Fauqued M Gil R Grueso J | 2010 | Int J Cancer2010，126，7： | 1 |
| 8 | Neurites regrowth of cortical neurons by GSK3-beta inhibition independently of Nogoreceptor显示文摘 | Seira O Gavín R Gil V | 2010 | J Neurochem2010，113，6： | 1 |
| 9 | Effect of the volume of medium and number of oocytes during in vitro fertilization on embryo development in pigs 显示文摘 | Gil M A Abeydeera L R Day B N | 2003 | Theriogenology2003，60，76： | 1 |
| 10 | Deterruination of photoirradiated high polar benzoylureas in tomato by HPLC with luminol chemiluminescence detection显示文摘 | Martinez Galera M Gil Gareia M D Santiago Valverde R | 2008 | Talanta2008，76，4： | 1 |
| 11 | Comparing features for target tracking in traffic scenes 显示文摘 | Gil S Milanese R Pun T | 1996 | Pattern Recognition1996，19，8： | 1 |
| 12 | Mitral valve repalaeement in rheumatic patients: effects of chordal preservation 显示文摘 | Garcta-Fuster R Estevez V Gil O | 2008 | Ann Tho- rae Stag2008，86，2： | 1 |
| 13 | Linking oxidative stress to inflammation:Toll-like receptors显示文摘 | Gil R Tsung A Billiar T | 2010 | Free Radic Biol Med2010，，9： | 1 |
| 14 | Land-cover change model validation by an ROC method for the Ipswich watershed, Massa-chuset, USA显示文摘 | PONTIUS R GIL J R LAURA C S | 2001 | Agriculture Ecosystems and Environ- ment2001，85，5： | 1 |
| 15 | 显示文摘 | Toscano J Vaβen R Gil A | 2006 | Surface and Coatings Technology2006，201，7： | 1 |
| 16 | Stepped-impedance lowpass filters with spurious pass-band suppression显示文摘 | J Garcia-Garcia J Bonache F Falcone J D Baena F Martin I Gil T Lopetegi M A G Laso A Marcotegui R Marques M Sorolla | 2004 | Electronic Letters2004，40，14： | 1 |
| 17 | Translocation of poly(ethylene glycol-co-hexadecyl)cyanoacrylate nanoparticles into rat brain endothelial cells:role of apolipoproteins in receptor-mediated endocytosis显示文摘 | Kim H R Andrieux K Gil S | 2007 | Biomacromolecules2007，8，3： | 1 |
| 18 | Effect of baseline quadriceps activation on changes in quadriceps strength after exer- cise therapy in subjects with knee osteoarthritis 显示文摘 | SCOPAZ K A PIVA S R GIL A B | 2009 | Arthritis Rheum2009，61，7： | 1 |
| 19 | Role of nucleotides in intestinal develop- ment and repair: implications for infant nutrition显示文摘 | Uauy R Quan R Gil A | 1994 | Nutr1994，，： | 1 |
| 20 | miR -143, miR- 222, and miR452 are useful as tumor stratification and noninvasive diagnostic biomarkers for bladder cancer 显示文摘 | Puerta- Gil P Garcia- Baquero R Jia AY | 2012 | Am J Pathol2012，180，5： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员