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| 1 | Validation of a serum microRNA panel as biomarkers for early diagnosis of hepatocellular carcinoma post-hepatitis C infection in Egyptian patients显示文摘AIM To investigate the prospective importance of serum micro(mi)RNAs(mi R-125 b, mi R-138 b, mi R-1269, mi R-214-5p, mi R-494, mi R375 and mi R-145) as early biomarkers for the diagnosis of hepatitis C virus(HCV)-related hepatocellular carcinoma(HCC).METHODS Two-hundred and fifty HCV4 a patients, 224 HCV4 aHCC patients, and 84 healthy controls were enrolled in the study. Expression levels of mi R214-5p, mi R-125 b, mi R-1269 and mi R-375 were quantified using quantitative real-time PCR.RESULTS Expression of the selected mi RNAs in serum wassignificantly lower in HCC patients than in the healthy controls, except for mi R-1269 and mi R-494. There was a significant difference between HCC and HCV patients, in particular for HCC and late stage fibrosis, rather than HCV patients and early fibrosis. It is obvious that mi R-1269 was significantly upregulated in HCC cases compared to hepatic fibrosis cases. Each mi RNA can show HCC progression. Multivariate logistic regression analysis indicated that the tested panel of mi RNAs(mi R214-5p, mi R-125 b, mi R-1269 and mi R-375) represent accurate and specific indictors of HCC development.CONCLUSION This study presents a panel of mi RNAs with strong power as putative diagnostic and prognostic biomarkers for HCV-induced HCC. Moreover, mi R-214-5p and mi R-1269 could be considered as early biomarkers for tracking the progress of liver fibrosis to HCC. | Moustafa Nouh Elemeery Ahmed Noah Badr Marwa Anwar Mohamed Doaa Ahmed Ghareeb | 2017 | World Journal of Gastroenterology2017，23，21： | 20 |
| 2 | 饲料污染物呕吐毒素对单胃动物家禽和猪肠道的影响显示文摘食品和饲料安全是世界性的重大课题,它提升了人们对控制食品和饲料霉菌毒素污染的关注,因为霉菌毒素污染会影响动物和人类的健康。呕吐毒素(DON)是镰刀霉菌毒素中的一种,对人体和多种动物有毒,猪对这种毒素最为敏感,鸡的耐受性最高。在欧洲,谷物通常含有呕吐毒素,因此是镰刀菌毒素污染的指标之一。人和动物摄入呕吐毒素通常会产生多种中毒症状,如肠道黏膜刺激或坏死、腹泻、呕吐及、食量下降、增重下降和免疫功能改变。 | 张江 Khaled Ghareeb Wageha A. | 2016 | 国外畜牧学(猪与禽)2016，36，3： | 4 |
| 3 | MicroRNA signature in patients with hepatocellular carcinoma associated with type 2 diabetes显示文摘BACKGROUND Nonalcoholic steatohepatitis-related cirrhosis is one of the liver complications in type 2 diabetes mellitus(T2DM)and reported to be a risk factor for developing hepatocellular carcinoma(HCC).A reliable screening biomarker of liver cirrhosis(LC)and HCC among T2DM patients is important to reduce the morbidity and mortality of this disease.MicroRNA(miRNA)is considered a key player in HCC and T2DM,and it might be a hidden culprit in diabetes-associated HCC,making it a promising reliable prognostic tool.AIM To investigate the signature of serum miRNAs as early biomarkers for the screening of HCC among diabetic patients.METHODS Expression profiles of miRNAs in serum samples of diabetic LC and diabetic HCC patients were assessed using Illumina sequencing;then,RT-qPCR was used to validate significantly altered miRNAs between the two groups.Candidate miRNAs were tested in serum samples of 200 T2DM patients,270 LC patients,200 HCC patients,and 225 healthy control subjects.Additionally,receiver operating characteristic(ROC)analysis,with area under the curve(AUC),was performed to assess the diagnostic performance of the screened miRNAs for discriminating HCC from LC and nonmalignant patients(LC+T2DM).RESULTS Expression of the sequenced miRNAs in serum was different in HCC vs LCpositive T2DM patients.Two miRNAs(miR-34a,miR-221)were significantly upregulated and five miRNAs(miR-16,miR-23-3p,miR-122-5p,miR-198,miR-199a-3p)were significantly down-regulated in HCC compared to LC patients.Analysis of ROC curve demonstrated that the combination of these seven miRNAs can be used as a reliable biomarker for detection of HCC in diabetic patients,as it could identify HCC with high diagnostic accuracy in diabetic LC patients(AUC=0.993)and in diabetic nonmalignant patients(AUC=0.961).CONCLUSION This study validates a panel of serum miRNAs that can be used as a reliable noninvasive screening biomarker of HCC among T2DM cirrhotic and noncirrhotic patients.The study recommends further research to shed light on a possible role of c-Met in T2DM-associated HCC via the miRNA regulatory pathway. | Moustafa Nouh Elemeery Marwa Anwar Mohamed Marwa Ahmed Madkour Mohammed Mohammed Shamseya Noha Mahmoud Issa Ahmed Noah Badr Doaa Ahmed Ghareeb Cheol-Ho Pan | 2019 | World Journal of Gastroenterology2019，25，42： | 3 |
| 4 | 饲料污染物呕吐毒素对单胃动物家禽和猪肠道的影响(续)显示文摘2.4呕吐毒素对营养素肠道吸收的影响在饲喂呕吐毒素污染饲料的鸡中首次观察到D-葡萄糖等多种关键营养素的肠道转运和摄取受到影响,这种影响也与动物生长速度较差有关。不过,呕吐毒素对体内营养素吸收的影响知之甚少。 | 张江(译) 何闪(图) Khaled Ghareeb Wageha A | 2016 | 国外畜牧学(猪与禽)2016，36，4： | 2 |
| 5 | Control strategies for Campylobacter infection in poultry production 显示文摘 | Ghareeb K Awad W A Mohnl M | 2013 | World''s Poultry Science Journal2013，69，1： | 1 |
| 6 | Effects of Transportation on Stress and Fear Responses of Growing Broilers Supplemented with Prebiotic or Probiotic显示文摘 | Ghareeb K Awad W A Nitsch S | 2008 | Poult Sci2008，7，7： | 1 |
| 7 | In vitro cultures of Silybum marianum and silymarin accumulation显示文摘 | RADY M R MATTER M A GHAREEB H A | 2014 | Journal of genetic engineering and iotechnology2014，12，： | 1 |
| 8 | Genotoxic effects of deoxynivalenol in broiler chickens fed with low protein diets 显示文摘 | Awad W A Ghareeb K Dadak A etal | 2012 | Poult Sci2012，91，： | 1 |
| 9 | Single and combined effects of deoxynivalenol mycotoxin and a microbial feed addi- tive on lymphocyte DNA damage and oxidative stress in broil- er chickens显示文摘 | Awad W A Ghareeb K Dadak A | 2014 | PLoS One2014，9，88： | 1 |
| 10 | For- mulation and optimization of orodispersible tablets of diazepam 显示文摘 | ABED K K HUSSEIN A A GHAREEB M M | 2010 | AAPS Pharm Sci Tech2010，11，1： | 1 |
| 11 | Decontamination and detoxification strategies for the Fusarium mycotoxin deoxyni- valenol in animal feed and the effectiveness of microbial biodeg- radation 显示文摘 | AWAD W A GHAREEB K BOHM J | 2010 | Food Additives & Contaminants Part A Chemistry Analysis Control Exposure & Risk Assessment2010，27，4： | 1 |
| 12 | Studies on Bacillus subtilis and Lactobacillus aci- dophilus, as potential probiotics, on the immune response and resistance of Tilapia nilotica (Oreochromis niloticus) to challenge infections 显示文摘 | Aly S M Abdel-Galil Ahmed Y Abdel-Aziz Ghareeb A | 2008 | Fish & Shellfish Immunology2008，25，1： | 1 |
| 13 | The toxicological impacts of the Fusarium mycotoxin, deoxynivalenol, in poultry flocks with special reference to immunotoxicity 显示文摘 | Awad Wageha Ghareeb | 2013 | Toxins2013，5，5： | 1 |
| 14 | Cerebral effect of acute normovolemic hemodilution during brain tumor resection显示文摘 | DAIF A A HASSAN Y M GHAREEB N A | 2012 | J Neurosurg Anesthesiol2012，24，1： | 1 |
| 15 | Effects of dietary inclusion of probiotic and synbiotic on growth performance, organ weights, and intestinal histomorphology of broiler chickens 显示文摘 | AWAD W A GHAREEB K ABDEL-RAHEEM S | 2009 | Poultry Science2009，88，1： | 1 |
| 16 | Inhalation injury as a prognostic factor for mortality in bum patients显示文摘 | EI-Hellbawy RH Ghareeb FM | 2011 | Ann Burns Fire Disasters2011，24，2： | 1 |
| 17 | Cerebral effect of acute normovolemic hemodilution during brain tumor resection 显示文摘 | Daif AA Hassan YM Ghareeb NA | 2012 | Journal ofneurosurgical anesthesiology2012，24，1： | 1 |
| 18 | Insights on the host stress, fear and growth responses to the deoxynivalenol feed contaminant in broiler chickens显示文摘 | Ghareeb K Awad W A Sid-Ahmed O E | 2014 | PLoS ONE2014，9，1： | 1 |
| 19 | 饲料污染物呕吐毒素对单胃动物家禽和猪肠道的影响(续完)显示文摘上期回顾:上一期介绍了呕吐毒素对营养素肠道吸收、对肠道通透性的影响和对紧密连接蛋白表达及其mRNA转录的影响。2.7呕吐毒素对肠道固有免疫反应的影响很早就发现局部免疫细胞,尤其是肠道相关免疫系统中的免疫细胞对肠道中呕吐毒素的暴露非常敏感,根据暴露的剂量、频度和时间不同,可引起免疫刺激或免疫抑制效果。 | 张江 Khaled Ghareeb | 2016 | 国外畜牧学(猪与禽)2016，36，5： | 1 |
| 20 | Using the extensor digitorum brevis mus-cle to improve donor-site morbidity of the dorsalis pedis flap显示文摘 | Ghareeb FM | 2002 | Plast Reconstr Surg2002，109，6： | 1 |
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