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2篇 您的检索式：作者名="Gerwin Dijk"

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		题名	作者	年代	出处	被引量
	1	Fabrication and in vivo 2-photon microscopy validation of transparent PEDOT:PSS microelectrode arrays显示文摘Transparent microelectrode arrays enable simultaneous electrical recording and optical imaging of neuronal networks in the brain.Electrodes made of the conducting polymer poly(3,4-ethylenedioxythiophene)doped with polystyrene sulfonate(PEDOT:PSS)are transparent;however,device fabrication necessitates specific processes to avoid deterioration of the organic material.Here,we present an innovative fabrication scheme for a neural probe that consists of transparent PEDOT:PSS electrodes and demonstrate its compatibility with 2-photon microscopy.The electrodes show suitable impedance to record local field potentials from the cortex of mice and sufficient transparency to visualize GCaMP6f-expressing neurons underneath the PEDOT:PSS features.The results validate the performance of the neural probe,which paves the way to study the complex dynamics of in vivo neuronal activity with both a high spatial and temporal resolution to better understand the brain.	Gerwin Dijk Attila Kaszas Jolien Pas Rodney Philip O’Connor	2022	Microsystems & Nanoengineering2022，8，4：	0
	2	Integrating flexible electronics for pulsed electric field delivery in a vascularized 3D glioblastoma model显示文摘Glioblastoma is a highly aggressive brain tumor,very invasive and thus difficult to eradicate with standard oncology therapies.Bioelectric treatments based on pulsed electric fields have proven to be a successful method to treat cancerous tissues.However,they rely on stiff electrodes,which cause acute and chronic injuries,especially in soft tissues like the brain.Here we demonstrate the feasibility of delivering pulsed electric fields with flexible electronics using an in ovo vascularized tumor model.We show with fluorescence widefield and multiphoton microscopy that pulsed electric fields induce vasoconstriction of blood vessels and evoke calcium signals in vascularized glioblastoma spheroids stably expressing a genetically encoded fluorescence reporter.Simulations of the electric field delivery are compared with the measured influence of electric field effects on cell membrane integrity in exposed tumor cells.Our results confirm the feasibility of flexible electronics as a means of delivering intense pulsed electric fields to tumors in an intravital 3D vascularized model of human glioblastoma.	Marie C.Lefevre Gerwin Dijk Attila Kaszas Martin Baca David Moreau Rodney P.O’Connor	2021	npj Flexible Electronics2021，5，1：	0

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