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| 1 | Evidence for the involvement of infectious agents in the pathogenesis of Crohn's disease显示文摘Many advances have been made in the understanding of Crohn’s disease (CD) pathogenesis during the last decade. CD is currently seen as a predominantly T-lym-phocyte-driven disease characterized by the presence of a complex cocktail of interacting cytokines, chemokines and other mediators produced by a variety of cell types. Prevailing theories of CD pathogenesis suggest that patients’ T-lymphocytes are inappropriately activated in the setting of an immune imbalance, which is itself caused by an unfortunate confluence of genetic and en- vironmental factors. The T-cell response then leads to the chronic inflammation characteristic for the disease. Various environmental factors may play a role in the development of CD, but microbes are most consistently implied. This theory is based on epidemiological, clinico- pathological, genetic and experimental evidence. Despite the abundance of arguments for the implication of bac-teria in the aetiopathogenesis of CD, the precise role of bacteria in this disease still remains elusive. Three not necessarily mutually exclusive theories have been pro- posed: (1) an unidentified persistent pathogen; (2) an abnormally permeable mucosal barrier leading to exces-sive bacterial translocation; and (3) a breakdown in the balance between putative 'protective' versus 'harmful' intestinal bacteria ('dysbiosis'). At present, one cannot exclude with certainty any of these three proposed hy-potheses; they may all apply to CD to a certain extent. | Gert De Hertogh Jeroen Aerssens Karen P Geboes Karel Geboes | 2008 | World Journal of Gastroenterology2008，14，6： | 11 |
| 2 | 中国的低碳转型与生态现代化显示文摘生态现代化理论探讨了国家在社会体制、经济发展和社会思想意识形态等方面的生态化转向,为政府、企业以及非政府团体和个人在面对环境问题时应该如何做出调整提供了一种新的思路。本文综述了生态现代化理论的核心思想和基本要素,并探讨了该理论发展过程中的主要争论。考虑目前国内经济的发展动态和发展低碳经济的迫切需求,这一理论对推动我国经济的低碳转型有着重要的借鉴意义。尤其是该理论发展过程中关于生产与消费的讨论,更为探讨发展低碳经济的核心定位等问题提供了参考。结合生态现代化观点和争论,本文提出我国经济的低碳转型,需要从尤其强调生产端导向的碳减排向同时兼顾上下游并重视消费者作用的战略思路转变;经济变革同时强调制度变革,转变行政命令控制为主的规制格局,促进多角色的参与;作为生产的微观主体,企业需强调以保护生态为己任的机构和管理改革,长远的发展更需要构建一种生产者与消费者之间有效衔接的消费导向战略。这些转变都将有利地推动中国经济的低碳现代化。 | 刘文玲 王灿 Spaargaren Gert Mol Arthur P J | 2012 | 中国人口·资源与环境2012，22，9： | 8 |
| 3 | Effect of rapamycin on hepatic osteodystrophy in rats with portasystemic shunting显示文摘瞄准:如果与推延的 portasystemic 有关的 T 房间激活通过 RANKL 依赖的小径引起调停骨破折的骨头损失,学习。如果用 rapamycin 的 T 房间抑制将在老鼠免于骨头损失,我们也调查了。方法:推延的 Portasystemic 在男 Sprague-Dawley 老鼠和 rapamycin 被执行 0.1 mg/kg 被管饲法为 15 wk 管理。老鼠收到了 powderized 食物并且补加喂在骨头作文上阻止营养不良的效果。重量获得和生长在推延的动物在外科以后被恢复。在结束,骨头周转和量的骨头组织学的生物化学的参数被估计。T 房间激活,煽动性的 cytokine 生产,和 RANKL 依赖的小径的标记被测量。另外, IGF-1 和性腺机能减退的角色被调查。结果:推延的 Portasystemic 引起了是 RANKL 独立人士的低周转骨质疏松症。包括 IL-1, IL-6 和 TNFalpha,骨头再吞 cytokine 层次没在浆液和 TNFalpha 被增加, RANKL 表示不起来在 PBMC 调整了。推延的 Portasystemic 增加了传播 CD8+T 房间人口。Rapamycin 减少了传播 CD8+T 房间人口,增加了 CD8+CD25+T 规章的房间人口并且改进了骨头周转的所有参数。结论:推延的 portasystemic 引起的骨质疏松症可以被 rapamycin 部分在肝的骨营养不良的老鼠模型改善。 | Schalk W van der Merwe Maria M Conradie Robert Bond Brenda J Olivier Elongo Fritz Martin Nieuwoudt Rhena Delport Tomas Slavik Gert Engelbrecht Del Kahn Enid G Shephard Maritha J Kotze Nico P de Villiers Stephen Hough | 2006 | World Journal of Gastroenterology2006，12，28： | 2 |
| 4 | Rapid determination of particle velocity from space-time images using the Radon transform 显示文摘 | Drew P J Pablo B Gert C | 2010 | Journal of Computational Neuro- science2010，29，1： | 1 |
| 5 | Ligment reconstraction with or without tendon interposition to treat primary thumb carpometacarpal osteoarthritis 显示文摘 | Gabriele K Gert P Eva F | 2004 | J Bone Joint Surg(Am)2004，86，2： | 1 |
| 6 | A conceptual framework for the OECD Health Care Quality Indicators Project显示文摘 | Onyebuchi A Gert P Jeremy H | 2006 | Interna- tional Journal for Quality in Health Care2006，，9： | 1 |
| 7 | Conversion of human bone marrow-derived mesenchymal stem cells into tendon progenitor cells by ectopic expression of scleraxis显示文摘 | Alberton P Popov C Prgert M | 2012 | Stem Cells Dev2012，21，6： | 1 |
| 8 | Changes in clusterin expression associated with light-induced retinal damage in rats 显示文摘 | Wong P Kutty RK Darrow RM Shivaram S Kutty G Fletcher RT Wig gert B Chader G Organisciak DT | 1994 | Biochem Cell Biol1994，72，1112： | 1 |
| 9 | Muddled or mixed? Inferring palaeoclimate from size distributions of deep-sea clastics显示文摘 | Gert J W Maarten A P | 2003 | Sedimentary Geology2003，162，： | 1 |
| 10 | Treatment options for developmental dislocation of the hip after walking age显示文摘 | Rudolf G Christof R Gert P | 2005 | J Pediatr Orthop2005，14，： | 1 |
| 11 | Treatment options for developmental dislocation of the hip after walking age 显示文摘 | Rudolf G Christof R Gert P | 2005 | J Pediatr Orthop2005，14，： | 1 |
| 12 | Gene-selective developmental roles of general transcription factors 显示文摘 | Gert J C Veenstra Alan P W | 2001 | Tredns Biochem Sci2001，26，： | 1 |
| 13 | Development of nitrile butadiene rubber-nanoclay composites with epoxidized natural rubber as compatibilizer显示文摘 | RAJASEKAR R KAUSHIK P GERT H | 2009 | Materials & Design2009，30，9： | 1 |
| 14 | Mutations in PMM2,a phosphomanno-mutase gene on chromosome 16p13 in carbohydrate-deficient glycoprotein type I syndrome(Jaeken syndrome)显示文摘 | Gert M Els S Els P | | 0，，： | 1 |
| 15 | PMM(PMM1),the Human Homo-logue of SEC53 or Yeast Phosphomannomutase,Is Localized on Chromosome 22q13显示文摘 | Gert M Els S Michel P | | 0，，01： | 1 |
| 16 | Arthroscopic treatment of septic arthritis in a patient with posterior stabilized total knee arthroplasty 显示文摘 | Gert KP Joachim H Wolf P | 2004 | Arthroscopy2004，20，： | 1 |
| 17 | The impact of calcium, magnesium, zinc, and copper in blood and seminal plasma on semen parameters in men 显示文摘 | Wai Y W Gert F Pascal M W Dorine W S Chris M G Jenny H J Hans M W Regine P M | 2001 | Reproductive Toxicology2001，15，2： | 1 |
| 18 | Intra-arterial thrombolytics during endovascular thrombectomy for acute ischaemic stroke in the MR CLEAN Registry显示文摘Introduction The efficacy and safety of local intra-arterial(IA)thrombolytics during endovascular thrombectomy(EVT)for large-vessel occlusions is uncertain.We analysed how often IA thrombolytics were administered in the Multicenter Randomized Clinical Trial of Endovascular Treatment for Acute Ischemic Stroke in the Netherlands(MR CLEAN)Registry,whether it was associated with improved functional outcome and assessed technical and safety outcomes compared with EVT without IA thrombolytics.Methods In this observational study,we included patients undergoing EVT for an acute ischaemic stroke in the anterior circulation from the MR CLEAN Registry(March 2014-November 2017).The primary endpoint was favourable functional outcome,defined as an modified Rankin Scale score≤2 at 90 days.Secondary endpoints were reperfusion status,early neurological recovery and symptomatic intracranial haemorrhage(sICH).Subgroup analyses for IA thrombolytics as primary versus adjuvant revascularisation attempt were performed.Results Of the 2263 included patients,95(4.2%)received IA thrombolytics during EVT.The IA thrombolytics administered were urokinase(median dose,250000 IU(IQR,193750-250000))or alteplase(median dose,20 mg(IQR,12-20)).No association was found between IA thrombolytics and favourable functional outcome(adjusted OR(aOR),1.16;95%CI 0.71 to 1.90).Successful reperfusion was less often observed in those patients treated with IA thrombolytics(aOR,0.57;95%CI 0.36 to 0.90).The odds of sICH(aOR,0.82;95%CI 0.32 to 2.10)and early neurological recovery were comparable between patients treated with and without IA thrombolytics.For primary and adjuvant revascularisation attempts,IA thrombolytics were more often administered for proximal than for distal occlusions.Functional outcomes were comparable for patients receiving IA thrombolytics as a primary versus adjuvant revascularisation attempt.Conclusion Local IA thrombolytics were rarely used in the MR CLEAN Registry.In the relatively small study sample,no statistical difference was observed between groups in the rate of favourable functional outcome or sICH.Patients whom required and underwent IA thrombolytics were patients less likely to achieve successful reperfusion,probably due to selection bias. | Sabine L Collette Reinoud P H Bokkers Aryan Mazuri Geert J LycklamaàNijeholt Robert J van Oostenbrugge Natalie E LeCouffe Faysal Benali Charles B L M Majoie Jan Cees de Groot Gert Jan R Luijckx Maarten Uyttenboogaart 无 | 2023 | Stroke & Vascular Neurology2023，8，1： | 0 |
| 19 | Management of extracranial carotid artery stenosis during endovascular treatment for acute ischaemic stroke:results from the MR CLEAN Registry显示文摘Background The optimal management of ipsilateral extracranial internal carotid artery(ICA)stenosis during endovascular treatment(EVT)is unclear.We compared the outcomes of two different strategies:EVT with vs without carotid artery stenting(CAS).Methods In this observational study,we included patients who had an acute ischaemic stroke undergoing EVT and a concomitant ipsilateral extracranial ICA stenosis of≥50%or occlusion of presumed atherosclerotic origin,from the Dutch Multicenter Randomized Clinical Trial of Endovascular Treatment for Acute Ischemic Stroke in the Netherlands(MR CLEAN)Registry(2014-2017).The primary endpoint was a good functional outcome at 90 days,defined as a modified Rankin Scale score≤2.Secondary endpoints were successful intracranial reperfusion,new clot in a different vascular territory,symptomatic intracranial haemorrhage,recurrent ischaemic stroke and any serious adverse event.Results Of the 433 included patients,169(39%)underwent EVT with CAS.In 123/168(73%)patients,CAS was performed before intracranial thrombectomy.In 42/224(19%)patients who underwent EVT without CAS,a deferred carotid endarterectomy or CAS was performed.EVT with and without CAS were associated with similar proportions of good functional outcome(47%vs 42%,respectively;adjusted OR(aOR),0.90;95%CI,0.50 to 1.62).There were no major differences between the groups in any of the secondary endpoints,except for the increased odds of a new clot in a different vascular territory in the EVT with CAS group(aOR,2.96;95%CI,1.07 to 8.21).Conclusions Functional outcomes were comparable after EVT with and without CAS.CAS during EVT might be a feasible option to treat the extracranial ICA stenosis but randomised studies are warranted to prove non-inferiority or superiority. | Sabine L Collette Michael P Rodgers Marianne A A van Walderveen Kars C J Compagne Paul J Nederkoorn Jeannette Hofmeijer Jasper M Martens Gert J de Borst Gert Jan R Luijckx Charles B L M Majoie Aad van der Lugt Reinoud P H Bokkers Maarten Uyttenboogaart | 2023 | Stroke & Vascular Neurology2023，8，3： | 0 |
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