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| 1 | VEGF-D expression correlates with colorectal cancer aggressiveness and is downregulated by cetuximab显示文摘AIM:To gain mechanistic insights into the role played by epidermal growth factor receptor (EGFR) in the regulation of vascular endothelial growth factors (VEGFs) in colorectal cancer (CRC). METHODS:The impact of high-level expression of the growth factor receptors EGFR and VEGF receptor (VEGFR)3 and the VEGFR3 ligands VEGF-C and VEGF-D on disease progression and prognosis in human CRC was investigated in 108 patients using immunohistochemistry. Furthermore, the expression of the lymphangiogenic factors in response to the modulation of EGFR signalling by the EGFR-targeted monoclonal antibody cetuximab was investigated at the mRNA and protein level in human SW480 and SW620 CRC cell lines and a mouse xenograft model. RESULTS: Human CRC specimens and cell lines displayed EGFR, VEGF-C and VEGF-D expression with varying intensities. VEGF-C expression was associated with histological grade. Strong expression of VEGF-D was significantly associated with lymph node metastases and linked to a trend for decreased survival in lymph node-positive patients. EGFR blockade with cetuximab resulted in a significant decrease of VEGF-D expression in vitro and in vivo. CONCLUSION:In conclusion, the expression of VEGF-D in colorectal tumours is significantly associated with lymphatic involvement in CRC patients and such expression might be blocked effectively by cetuximab. | Markus Moehler Christian Frings Annett Mueller Ines Gockel Carl C Schimanski Stefan Biesterfeld Institute of Pathology Johannes Gutenberg University Mainz 55101 Germany Peter R Galle Martin H Holtmann | 2008 | World Journal of Gastroenterology2008，14，26： | 15 |
| 2 | Optimal controlled teleportation via several kinds of three-qubit states显示文摘The probability of successful controlled teleportation of an unknown qubit using a general three-particle state is investigated. The analytic expressions of maximal probabilities via several kinds of tripartite states are given, including a tripartite Greenberger-Horne-Zeilinger state and a tripartite W-state. | GAO Ting1,2, YAN FengLi2,3 & LI YouCheng3 1 College of Mathematics and Information Science, Hebei Normal University, Shijiazhuang 050016, China 2 Max-Planck-Institut für Quantenoptik, Hans-Kopfermann-Str. 1, D-85748 Garching, Germany 3 College of Physics and Information Engineering, Hebei Normal University, Shijiazhuang 050016, China | 2008 | Science China(Physics,Mechanics & Astronomy)2008，51，10： | 9 |
| 3 | A Coupled Variable Coefficient Modified KdV Equation Arising from a Two-Layer Fluid System显示文摘A quite general coupled variable coefficient modified KdV (VCmKdV) equation in a two-layer fluid systemis derived by means of the reductive perturbation method.Making use of the CK's direct method,some similarityreductions of the coupled VCmKdV equation are obtained and their corresponding group explanations are discussed.Some exact solutions of the coupled equations are also presented. | GAO Yuan~1 and TANG Xiao-Yan~(1,2)~1 Department of Physics,Shanghai Jiao Tong University,Shanghai 200240,China~2 Institut Für Theoretische Physik IV,Fakultt für Physik und Astronomie,Ruhr-Universitt Bochum,D-44870 Bochum,Germany | 2007 | Communications in Theoretical Physics2007，，12： | 3 |
| 4 | LAVES PHASE ALLOYS FOR HIGH TEMPERATURE APPLICATIONS显示文摘Ternary Laves phases with transition metals and aluminium were overviewed with respect to their use for structural high temperature applications. The relation between constitution, phase stability, crystal structure and basic mechanical properties was discussed. The crystal structure-hexagonal C14 structure or cubic C15 structure-is a function of atomic radii and valence electron concentration. A strong positive correlation of basic mechanical properties-hardness, yield stress-with the sublimation energy of the phases was found. The brittle to ductile transition temperature was observed at about 60% of the melting temperature. The regarded ternary Laves phases allow alloying to form stable equilibria with the less hard and brittle B2 aluminides. Advantageous examples are alloys of type NbNiAl NiAl, TaNiAl NiAl, and TaFeAl FeAl. Multiphase NiAl Ta Cr alloys are regarded as promising for structural high temperature applications and have been selected for a materials development which aims at applications in gas turbines at temperatures above those of Ni base superalloys, such alloy can be prepared by ingot metallurgy and powder metallurgy and hot forming is possible. Characteristic data were presented with respect to mechanical behaviour. The alloys showed a high thermoshock resistance in spite of the comparatively high brittle to ductile transition temperature. The prospects of alloy development were discussed. | G.Sauthoff Max Planck Institut für Eisenforschung Gmbh., D 40074 Düsseldorf, Germany | 1999 | 中国有色金属学会会刊:英文版1999，9，S1： | 2 |
| 5 | RANDOM SYSTEMS OF HARD PARTICLES:MODELS AND STATISTICS显示文摘This paper surveys models and statistical properties of random systems of hard particles. Such systems appear frequently in materials science, biology and elsewhere. In mathematical-statistical investigations, simulations of such structures play an important role. In these simulations various methods and models are applied, namely the RSA model, sedimentation and collective rearrangement algorithms, molecular dynamics, and Monte Carlo methods such as the Metropolis-Hastings algorithm. The statistical description of real and simulated particle systems uses ideas of the mathematical theories of random sets and point processes. This leads to characteristics such as volume fraction or porosity, covariance, contact distribution functions, specific connectivity number from the random set approach and intensity, pair correlation function and mark correlation functions from the point process approach. Some of them can be determined stereologically using planar sections, while others can only be obtained using three-dimensional data and 3D image analysis. They are valuable tools for fitting models to empirical data and, consequently, for understanding various materials, biological structures, porous media and other practically important spatial structures. | Dietrich Stoyan (Institut für Stochastik, TU Bergakademie Freiberg, 09596 Freiberg, Germany) | 2002 | 中国体视学与图像分析2002，7，1： | 2 |
| 6 | Effect of sugars, lipids and type of starch on the modeand kinetics of retrogradation of concentrated com starchgels显示文摘 | GERMANI R’ CIACCO C F RODRIGUEZ-AMAYAD B | 1983 | Starch-Starke1983，35，11： | 1 |
| 7 | Mercury extraction by ionic liquids:Temperature and alkyl chain length effect显示文摘 | Germani R Mancini M V Savelli G | 2007 | Tetrahedron Lett2007，48，10： | 1 |
| 8 | Effect of sugars, lipids and type of starch on the mode and kinetics of retrogradation of concentrated corn starch gels显示文摘 | Germani R Ciacco C F | 1983 | Starch1983，35，11： | 1 |
| 9 | Fat density in renal cell carcinoma:demonstration with computerized tomography显示文摘 | Germany R Peavy PW | 1997 | J Urol1997，157，4： | 1 |
| 10 | Effect of Sugars,Lipids and type of starch on the mode and kinetincs of retrogradation of concentrated corn starch gels显示文摘 | Germani R Ciacco C F Rodriguez-Amaya D B | 1983 | Starch/Strke1983，35，11： | 1 |
| 11 | Endoscopic reconstruction of large anterior skull base defects using acellular dermal allograft显示文摘 | Germani RM Vivero R Herzallah IR | 2007 | Am J Rhinol2007，21，5： | 1 |
| 12 | Fat density in renal cell carcinoma:demonstration with computerized tomo-graphy显示文摘 | Henderson RJ Germany R Peavy PW | 1997 | J Urol1997，157，： | 1 |
| 13 | Endoscopic transnasal study of the infratemporal fossa: a new orientation 显示文摘 | Herzallah IR Germani R Casiano RR | 2009 | Otolaryngol Hcad Neck Surg2009，140，6： | 1 |
| 14 | Enantioselective Epoxidations of Alkenes Catalyzed by ( Salen ) Mn ( Ⅲ ) in Aqueous Surfactant Systems显示文摘 | Ballistreri F P Brinchi L Germani R | 2008 | Tetrahedron2008，4，10： | 1 |
| 15 | Fat density in renal cell carcinoma:demonstration with computerized tomography 显示文摘 | Henderson RJ Germany R Peavy PW | 1997 | J Urol1997，157，： | 1 |
| 16 | The three phases of value capture显示文摘 | Germany R Muralidharan R | 2001 | Strategy & Business2001，22，1： | 1 |
| 17 | Liver transplantation for acute liver failure in Europe : outcomes over 20 years from the ELTR database 显示文摘 | Germani G Theocharidou E Adam R | 2012 | J Hepatol2012，57，2： | 1 |
| 18 | Fat density in renal cell carcinoma:demonstration with computerized tomography显示文摘 | Hendeson RJ Germany R Peary PW | | 0，，11： | 1 |
| 19 | A method for performance evaluation of RE/RP systems in dentistry显示文摘 | Germani M Raffaeli R Mazzoli A | 2010 | Rapid Prototyping J2010，16，5： | 1 |
| 20 | Fat density in renal cell carcinoma: Demonstration with computerized tomography 显示文摘 | Henderson RJ Germany R Peavy PW | 1997 | J Urol1997，157，： | 1 |
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