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| 1 | Clinical outcomes of isolated renal failure compared to other forms of organ failure in patients with severe acute pancreatitis显示文摘AIM To assess differences in clinical outcomes of isolated renal failure(RF) compared to other forms of organ failure(OF) in patients with severe acute pancreatitis(SAP).METHODS Using a prospectively maintained database of patients with acute pancreatitis admitted to a tertiary medical center between 2003 and 2016, those with evidence of persistent OF were classified to renal, respiratory, cardiovascular, or multi-organ(2 or more organs). Data regarding demographics, comorbidities, etiology of acute pancreatitis, and clinical outcomes were prospectively recorded. Differences in clinical outcomes after development of isolated RF in comparison to other forms of OF were determined using independent t and Mann-Whitney U tests for continues variables, and χ~2 test for discrete variables.RESULTS Among 500 patients with acute pancreatitis, 111 patients developed persistent OF: mean age was 54 years, and 75(67.6%) were male. Forty-three patients had isolated OF: 17(15.3%) renal, 25(21.6%) respiratory, and 1(0.9%) patient with cardiovascular failure. No differences in demographics, etiology of acute pancreatitis, systemic inflammatory response syndrome scores, or development of pancreatic necrosis were seen between patients with isolated RF vs isolated respiratory failure. Patients with isolated RF were less likely to require nutritional support(76.5% vs 96%, P = 0.001), ICU admission(58.8% vs 100%, P = 0.001), and had shorter mean ICU stay(2.4 d vs 15.7 d, P < 0.001), compared to isolated respiratory failure. None of the patients with isolated RF or isolated respiratory failure died.CONCLUSION Among patients with SAP per the Revised Atlanta Classification, approximately 15% develop isolated RF. This subgroup seems to have a less protracted clinical course compared to other forms of OF. Isolated RF might be weighed less than isolated respiratory failure in risk predictive modeling of acute pancreatitis. | Amir Gougol Mohannad Dugum Anwar Dudekula Phil Greer Adam Slivka David C Whitcomb Dhiraj Yadav Georgios I Papachristou | 2017 | World Journal of Gastroenterology2017，23，29： | 20 |
| 2 | Acute upper gastrointestinal bleeding in patients on long-term oral anticoagulation therapy: Endoscopic findings, clinical management and outcome显示文摘AIM: Acute gastrointestinal bleeding is a severe complication in patients receiving long-term oral anticoagulant therapy.The purpose of this study was to describe the causes and clinical outcome of these patients.METHODS: From January 1999 to October 2003, 111patients with acute upper gastrointestinal bleeding (AUGIB)were hospitalized while on oral anticoagulants. The causes and clinical outcome of these patients were compared with those of 604 patients hospitalized during 2000-2001with AUGIB who were not taking warfarin.RESULTS: The most common cause of bleeding was peptic ulcer in 51 patients (45%) receiving anticoagulants compared to 359/604 (59.4%) patients not receiving warfarin (P<0.05). No identifiable source of bleeding could be found in 33 patients (29.7%) compared to 31/604(5.1%) patients not receiving anticoagulants (P= 0.0001).The majority of patients with concurrent use of non-steroidal anti-inflammatory drugs (NSATDs) (26/35, 74.3%) had a peptic ulcer as a cause of bleeding while 32/76 (40.8%)patients not taking a great dose of NSATDs had a negative upper and lower gastrointestinal endoscopy. Endoscopic hemostasis was applied and no complication was reported.Six patients (5.4%) were operated due to continuing or recurrent hemorrhage, compared to 23/604 (3.8%) patients not receiving anticoagulants. Four patients died, the overall mortality was 3.6% in patients with AUGIB due to anticoagulants, which was not different from that in patients not receiving anticoagulant therapy.CONCLUSION: Patients with AUGIB while on long-term anticoagulant therapy had a clinical outcome, which is not different from that of patients not taking anticoagulants.Early endoscopy is important for the management of these patients and endoscopic hemostasis can be safely applied. | Konstantinos C Thomopoulos Konstantinos P Mimidis George J Theocharis Anthie G Gatopoulou Georgios N Kartalis Vassiliki N Nikolopoulou | 2005 | World Journal of Gastroenterology2005，11，9： | 5 |
| 3 | Are acute exacerbations of chronic inflammatory appendicitis triggered by coprostasis and/or coproliths?显示文摘AIM: To examine the role of coprostasis and coproliths in recurrent appendicitis. METHODS: We evaluated four hundred and twenty seven consecutive pathology reports of all appende- ctomy specimens from January 2003 to December 2004. Findings were categorised as showing acute appen- dicitis, acute recurrent appendicitis, subacute recurrent appendicitis, chronic appendicitis, or appendices without inflammation. All patients had presented with acute right lower quadrant pain. In 94 instances, there was a history of recurrent similar episodes in the past. RESULTS: Of the 427 histology reports, 294 were inter- preted as showing acute appendicitis, 56 acute recurrent appendicitis, 34 subacute recurrent appen-dicitis, 28 chronic appendicitis, and 15 non-inflamed appendices. Coprostasis was observed in 58 patients (13.58%) and the presence of coprolith in 6 (1.4%). Coprostasis, and age, were among the predictors in the final model. CONCLUSION: Coprostasis but not coproliths seems to be a contributing factor to acute exacerbations of chronic inflammatory appendicitis. | George Sgourakis Georgios C Sotiropoulos Ernesto P Molmenti Charis Eibl Stylianous Bonticous Jurgen Moege Christoph Berchtold | 2008 | World Journal of Gastroenterology2008，14，20： | 5 |
| 4 | Totally laparoscopic left hepatectomy using the Torsional Ultrasonic Scalpel显示文摘Minimal invasive techniques have allowed for major surgical advances.We report our initial experience of performing total laparoscopic left hepatectomy(segmentsⅡ-Ⅳ)with the Lotus(laparoscopic operation by torsional ultrasound)Ultrasonic Scalpel.The perioperative and postoperative courses of the young female patient were uneventful and she is in a good general condition without complaints 18 mo after surgery.To the best of our knowledge,this is the first total laparoscopic hemihepatectomy to be performed in Greece,as well as the first laparoscopic liver resection using Lotus shears. | Georgios C Sotiropoulos Paraskevas Stamopoulos Petros Charalampoudis Ernesto P Molmenti Athanasios Voutsarakis Gregory Kouraklis | 2013 | World Journal of Gastroenterology2013，19，35： | 5 |
| 5 | Intestinal barrier dysfunction in cirrhosis: Current concepts in pathophysiology and clinical implications显示文摘The intestinal lumen is a host place for a wide range of microbiota and sets a unique interplay between local immune system, inflammatory cells and intestinal epithelium, forming a physical barrier against microbial invaders and toxins. Bacterial translocation is the migration of viable or nonviable microorganisms or their pathogen-associated molecular patterns, such as lipopolysaccharide, from the gut lumen to the mesenteric lymph nodes, systemic circulation and other normally sterile extraintestinal sites. A series of studies have shown that translocation of bacteria and their products across the intestinal barrier is a commonplace in patients with liver disease. The deterioration of intestinal barrier integrity and the consulting increased intestinal permeability in cirrhotic patients play a pivotal pathophysiological role in the development of severe complications as high rate of infections, spontaneous bacterial peritonitis, hepatic encephalopathy, hepatorenal syndrome, variceal bleeding, progression of liver injury and hepatocellular carcinoma. Nevertheless, the exact cellular and molecular mechanisms implicated in the phenomenon of microbial translocation in liver cirrhosis have not been fully elucidated yet. | Georgios I Tsiaoussis Stelios F Assimakopoulos Athanassios C Tsamandas Christos K Triantos Konstantinos C Thomopoulos | 2015 | World Journal of Hepatology2015，7，17： | 4 |
| 6 | Global warming and carbon dioxide through sciences显示文摘 | Georgios A F Paul C | 2009 | Environmentallnternational2009，35，2： | 1 |
| 7 | A two dimensional numerical study of the stick-slip extrusion instability显示文摘 | ELENI T GEORGIOS C G ANDREAS N A | 2007 | J Non-Newton Fluid Mech2007，146，： | 1 |
| 8 | On the stability of the shear flow of a viscoelastic fluid with slip along the fixed wall 显示文摘 | Georgios C Georgiou | 1996 | J Rheol1996，，： | 1 |
| 9 | Integrated uhrasound and biochemical screening for trisomy 21 using fetal nuchal translucency, absent fetal nasal bone, free β-hCG and PAPP-A at 11 to 14 weeks显示文摘 | Simona C Renu B Georgios R | 2003 | Prenat Diagn2003，，23： | 1 |
| 10 | Sliding osteotomy for deformity correction following realunion of volarly displaced distal radial fractures 显示文摘 | Georgios C | 2003 | Journal of Orthopaedic Trauma2003，17，： | 1 |
| 11 | FamiLiaL cancer history in patients with carcinoma of the cervix uteri 显示文摘 | Lars C H Georgios R | 2002 | Eur J Obstet GynoL Reprod BioL2002，101，： | 1 |
| 12 | A study of various factors affecting Newtonian extrudate swell显示文摘 | Mitsoulis E Georgios G C Kountouriotis Z | 2012 | Comput Fluids2012，57，4： | 1 |
| 13 | Growth,yield and fruit quality of Shamouti or-ange fourteen rootstocks in Cyprus显示文摘 | Georgioe C | 1999 | Scientia Horticul-turae1999，80，： | 1 |
| 14 | Open-cage fullerene derivatives with 15-membered-ring orifices 显示文摘 | Georgios C V Kosmas P Josep M C | 2004 | J Org Chem2004，69，13： | 1 |
| 15 | Global warming and carbon di- oxide through sciences 显示文摘 | Georgios A Paul C | 2009 | Environ Inter2009，35，2： | 1 |
| 16 | Distributedclustering using wireless sensor networks显示文摘 | PEDRO A F ALFONSO C GEORGIOS B G | 2011 | IEEE Trans-actions on Signal Processing2011，5，4： | 1 |
| 17 | High performance cooperative demodulation with decode and forward relays显示文摘 | WANG Tai-ran ALFOSO C GEORGIOS B | 2007 | IEEE Trans Wirelesscom2007，55，7： | 1 |
| 18 | Breit-Pauli energy levels, lifetimes, and transition data: beryllium-like spectra显示文摘 | GEORGIO Tachiev C Froese Fischer | 1999 | Phys B: At Mol Opt Phys1999，32，： | 1 |
| 19 | Allergy to artichoke: a case report 显示文摘 | Luigi M Simonetta B P Raffaella di G Georgios K Maria F C Alfredo T | 2004 | Revue Francaise d'' Allergologie et d ''Immunologie Clinique2004，44，8： | 1 |
| 20 | Predictors of pulmonary zygomycosis versus invasive pulmonary aspergillosis in patients with cancer显示文摘 | Georgios C Edith MM Russell EL | 2005 | Clin Infect Dis2005，41，： | 1 |
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