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| 1 | Hypothalamic-pituitary-adrenal axis function during perinatal depression显示文摘Abnormal function of the hypothalamic–pituitary–adrenal(HPA) axis is an important pathological finding in pregnant women exhibiting major depressive disorder. They show high levels of cortisol proinflammatory cytokines, hypothalamic-pituitary peptide hormones and catecholamines, along with low dehydroepiandrosterone levels in plasma. During pregnancy, the TH2 balance together with the immune system and placental factors play crucial roles in the development of the fetal allograft to full term. These factors, when altered, may generate a persistent dysfunction of the HPA axis that may lead to an overt transfer of cortisol and toxicity to the fetus at the expense of reduced activity of placental 11β-hydroxysteroid dehydrogenase type 2. Epigenetic modifications also may contribute to the dysregulation of the HPA axis. Affective disorders in pregnant women should be taken seriously, and therapies focused on preventing the deleterious effects of stressors should be implemented to promote the welfare of both mother and baby. | Phillipe Leff Gelman Mónica Flores-Ramos Margarita López-Martínez Carlos Cruz Fuentes Juan Pablo Reyes Grajeda | 2015 | Neuroscience Bulletin2015，31，3： | 6 |
| 2 | Development and evaluation of a safe and effective sugar-free herbal lollipop that kills cavity-causing bacteria显示文摘Dental caries (tooth decay) is caused by a specific group of cariogenic bacteria, like Streptococcus mutans, which convert dietary sugars into acids that dissolve the mineral in tooth structure. Killing cariogenic bacteria is an effective way to control or prevent tooth decay. In a previous study, we discovered a novel compound (Glycyrrhizol A), from the extraction of licorice roots, with strong antimicrobial activity against cariogenic bacteria. In the current study, we developed a method to produce these specific herbal extracts in large quantities, and then used these extracts to develop a sugar-free lollipop that effectively kills cariogenic bacteria like Streptococcus mutans. Further studies showed that these sugar-free lollipops are safe and their antimicrobial activity is stable. Two pilot human studies indicate that a brief application of these lollipops (twice a day for ten days) led to a marked reduction of cariogenic bacteria in oral cavity among most human subjects tested. This herbal lollipop could be a novel tool to promote oral health through functional foods. | Chu-hong Hu Jian He Randal Eckert Xiao-yang Wu Li-na Li Yan Tian Renate Lux Justin A. Shuffer Faina Gelman Janet Mentes Sue Spackman Janet Bauer Maxwell H. Anderson Wen-yuan Shi | 2011 | International Journal of Oral Science2011，3，1： | 3 |
| 3 | The virologic, immunologic, and chnical effects of interleukin 2 with potent antiretroviral therapy in patients with moderately advanced human immunodeficiency virus infection: a randomized controlled clinical trial-AIDS Clinical Trials Group 328显示文摘 | Mitsuyasu R Gelman R Chemg DW | 2007 | Arch Intern Med2007，167，6： | 1 |
| 4 | Multiprotein bridging factor-1(MBF-1) is a cofactor for nuclear receptors that regulate lipid metabolism显示文摘 | CAROLE BRENDEL LAURENT GELMAN JOHAN AUWERX | 2002 | Molecular Endocrinology2002，16，6： | 1 |
| 5 | Surface-modified diamond nanoparticles as antigen delivery vehicles显示文摘 | Kossovsky N Gelman A Hnatyszyn HJ | 1995 | Bioconjug Chem1995，6，5： | 1 |
| 6 | Developmental Changes in the Consideration of Sample Diversity in Inductive Reasoning显示文摘 | Marjorie Rhodes Susan A. Gelman Daniel Brickman | 2008 | Journal of Cognition and Development2008，，1： | 1 |
| 7 | Determinants of increased regional left atrial coagulation activity in patients with mitral stenosis显示文摘 | Harper RW Gelman J | 1996 | Circulation1996，94，3： | 1 |
| 8 | Tearing of blast loaded plates with clamped boundary conditions 显示文摘 | Nurick G N Gelman M E Marshall N S | 1996 | Int J Impact Engineering1996，18，78： | 1 |
| 9 | inter-observer reproducibility in the diagnosis of ductal proliferative breast lesions using standardized criteria显示文摘 | Schnitt SJ Connolly JL Tavassoli FA Fechner RE Kempson RL Gelman R Page DL | 1992 | Am J Surg Pathol1992，16，12： | 1 |
| 10 | Alternative methods for monitoring convergence of iterative simulations显示文摘 | BROOKS S P GELMAN A | 1998 | Journal of Computational and Graphical Statistics1998，7，4： | 1 |
| 11 | Selective brain cooling in infant piglet after cardiac arrest and resuscitation显示文摘 | Gelman B Schlein CL Lohe A | 1996 | Crit Care Med1996，24，： | 1 |
| 12 | Novel Adaptation of the Demodulation Technology for Gear Damage Detection to Variable Amplitudes of Mesh Harmonics显示文摘 | Combet F Gelman L | 2011 | Mechanical Systems and Signal Processing2011，25，3： | 1 |
| 13 | Autoimmunity heats up显示文摘 | Gelman AE Turka LA | 2003 | Nat Med2003，9，12： | 1 |
| 14 | Pattern of alloimmune response in second same donor allografts after induction of tolerance using CTLA4Ig显示文摘 | Oltholf KM Gelman AE Zamir GA | 2001 | Transplantation2001，72，12： | 1 |
| 15 | Multilevel algorithms for optimization problems显示文摘 | Gelman E Mandel J | 1990 | Math Progr Ser B1990，48，： | 1 |
| 16 | Reducing waste contamination from animal-processing plants by anaerobic thermophilic fermentation and by flesh fly digestion显示文摘 | MARCHAIM U GELMAN A BRAVERMAN Y | 2003 | Applied Biochemistry and Biotechnology2003，109，： | 1 |
| 17 | Intracranial germcelltumors:natural history and pathgenesis显示文摘 | Jennings MT Gelman R Hochbeg F | 1985 | J Neurosurg1985，63，： | 1 |
| 18 | Control of cytoskeletal architecture by the src-suppressed C kinase substrate,SSeCKS显示文摘 | Gelman I H Lee K Tombler E | 1998 | Cell Motil Cytoskeleton1998，41，1： | 1 |
| 19 | An automated methodology for performing time synchronous averaging of a gearbox signal without speed sensor显示文摘 | COMBET F GELMAN L | 2007 | Mechanical Systems and Signal Processing2007，21，6： | 1 |
| 20 | A prospective study of conservative surgery without radiation therapy in select patients with stage I breast cancer显示文摘 | M Lim JR Bellon R Gelman | 2006 | International Jour- nal of Radiation Oncology Biology Physics2006，65，4： | 1 |
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