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| 1 | Nat Genet:单基因突变导致过敏性皮炎的发生显示文摘最近,研究者们鉴定出了一类导致神经性皮炎发生的关键基因突变:CARDll。来自美国NIH过敏与传染病研究所的研究者们通过对四个没有血缘关系的患病家庭进行分析,发现了这一导致疾病产生的基因、 | Chi A Ma, Yuan Zhang, Michael A Weinreich, Jonathan J Lyons, Celeste G Nelson, Thomas DiMaggio, Kelly D Stone, Joshua D Milner Jeffrey R Stinson, Elisa Ruffo, Batsukh Dorjbal, Swadhinya Arjunaraja, Kelsey Voss, Andrew L Snow Jordan K Abbott, Pia J Hauk, Paul R Reynolds, Erwin W Gelfand Elisa Ruffo Salomé Glauzy, Natsuko Yamakawa, Eric Meffre Jennifer Stoddard, Julie Niemela, Sergio D Rosenzweig Yu Zhang, Helen F Matthews Joshua J McElwee Nina Jones Alejandro Palma, Matías Oleastro, Emma Prieto, Andrea R Bernasconi, Geronimo Dubra, Silvia Danielian, Jonathan Zaiat, Marcelo A Marti Brian Kim Megan A Cooper Neil Romberg | 2017 | 现代生物医学进展2017，17，27： | 3 |
| 2 | Intravenous immune globulin suppresses angiogenesis in mice and humans显示文摘Human intravenous immune globulin(IVIg),a purified IgG fraction composed of~60%IgG1 and obtained from the pooled plasma of thousands of donors,is clinically used for a wide range of diseases.The biological actions of IVIg are incompletely understood and have been attributed both to the polyclonal antibodies therein and also to their IgG(IgG)Fc regions.Recently,we demonstrated that multiple therapeutic human IgG1 antibodies suppress angiogenesis in a target-independent manner via FcγRI,a high-affinity receptor for IgG1.Here we show that IVIg possesses similar anti-angiogenic activity and inhibited blood vessel growth in five different mouse models of prevalent human diseases,namely,neovascular age-related macular degeneration,corneal neovascularization,colorectal cancer,fibrosarcoma and peripheral arterial ischemic disease.Angioinhibition was mediated by the Fc region of IVIg,required FcγRI and had similar potency in transgenic mice expressing human FcγRs.Finally,IVIg therapy administered to humans for the treatment of inflammatory or autoimmune diseases reduced kidney and muscle blood vessel densities.These data place IVIg,an agent approved by the US Food and Drug Administration,as a novel angioinhibitory drug in doses that are currently administered in the clinical setting.In addition,they raise the possibility of an unintended effect of IVIg on blood vessels. | Reo Yasuma Valeria Cicatiello Takeshi Mizutani Laura Tudisco Younghee Kim Valeria Tarallo Sasha Bogdanovich Yoshio Hirano Nagaraj Kerur Shengjian Li Tetsuhiro Yasuma Benjamin J Fowler Charles B Wright Ivana Apicella Adelaide Greco Arturo Brunetti Balamurali K Ambati Sevim Barbasso Helmers Ingrid E Lundberg Ondrej Viklicky Jeanette HW Leusen J Sjef Verbeek Bradley D Gelfand Ana Bastos-Carvalho Sandro De Falco Jayakrishna Ambati | 2016 | Signal Transduction and Targeted Therapy2016，1，1： | 3 |
| 3 | Technica feadibility of colon imaging with helical CT and virtual reality 显示文摘 | Vining DJ Gelfand Bechtold RE | 1994 | AJR1994，，： | 2 |
| 4 | 组胺受体H1和H4在过敏性炎症中的作用:新型抗组胺药的研究显示文摘组胺在过敏性炎症中起关键性作用,长期以来人们认为组胺释放引起的炎性反应是由H1受体介导的。H1受体拮抗剂也称为抗组胺药,用于治疗过敏性反应已很多年。但是在哮喘和慢性瘙痒症的病理状态下组胺的重要性可能被低估。已证明组胺的确在炎症和免疫调节疾病中起作用,特别是H4受体的发现及其在多种免疫和炎性细胞中的表达,提示应重新评价组胺的作用,预示新型H4受体拮抗剂将被发现,且H1,H4受体拮抗剂在许多炎性反应靶标上可能有协同作用。 | Thurmond RL Gelfand EW Dunford PJ 刘洪英 肖志勇 | 2008 | 国际药学研究杂志2008，35，4： | 2 |
| 5 | An iterative growing and pruning algorithm for classification tree design显示文摘 | Saul B Gelfand C S Ravishankar Edward J Delp | 1991 | IEEE Transaction on Pattern Analysis and Machine Intelligence1991，13，2： | 1 |
| 6 | Interleukin 1 induces a shock-like state in rabbits: Synergism with tumor necrosis factor and the effect of cycloocxygenase inhibition显示文摘 | Dinarello C A Okusawa S Gelfand J A | 1989 | Prog Clin Biol Res1989，286，4： | 1 |
| 7 | Comparison of the senstivity and specificity of the CA199 and carcinormor embrvoni Canfigenassays in detecting cancer of the pancreatis显示文摘 | Steinberg WM Gelfand R Anderson KK | 1986 | Gastroenterol1986，90，： | 1 |
| 8 | Technical feasibiltiy of colon imaging with helical CT and virtual reality(abstr)显示文摘 | Vining DJ Gelfand DW Bechtold RE | 1994 | AJR1994，，： | 1 |
| 9 | Technical feasibility of colon imaging with helical CT and virtual reality显示文摘 | Vining DJ Gelfand DW Bechtold DE | 2003 | AJR2003，，： | 1 |
| 10 | Primerdirected enzymatic amplification of DNA with a thermostable DNA polymerase显示文摘 | SAIKI RK GELFAND DH STOTTELS A | 1988 | Science1988，239，： | 1 |
| 11 | Hierarchical spatio-temporal mapping of disease rates 显示文摘 | Waller L A Carlin B P Xia H Gelfand A E | 1997 | Journal of the American Statistical Association1997，92，60： | 1 |
| 12 | Pediatrics:diagnosis of neuroblastoma显示文摘 | Sharp S E Gelfand M J Shulkin B L | 2011 | Semin Nucl Med2011，41，5： | 1 |
| 13 | Reassembling fractured ob- jects by geometric matcbing 显示文摘 | Huang Q x Flry S Gelfand N | 2006 | Transactions Graphics2006，25，3： | 1 |
| 14 | 1231-MIBG scintigraphy and 18F-FDG PET in neuroblastoma显示文摘 | Sharp SE Shulkin BL Gelfand MJ | 2009 | J Nucl Med2009，50，： | 1 |
| 15 | Primer directed enzymatic amplification of DNA with a thermostable DNA polymerase显示文摘 | Gelfand D H Erlich H A | 1988 | Science1988，239，： | 1 |
| 16 | Closure of laparotomy incisions with or without peritoneal suturing and second-look laparoscopy显示文摘 | Tulandi T Ham HS Gelfand MM | 1988 | Am J Obstet Gynecol1988，158，31： | 1 |
| 17 | Cultural Influences on Cognitive Representations of Conflict : Interpretations of Conflict Episodes in the United States and Japan显示文摘 | Gelfand M J Nishii L H Ohbuehi K - I | 2001 | Journal of Applied Psychology2001，86，6： | 1 |
| 18 | Amino Acid Residues that Determine Functional Specificity of NADP- and NAD-Dependent Isocitrate and Isopropylmalate Dehydrogenases 显示文摘 | KALININA O V GELFAND M S | 2006 | Proteins: Structure Function and Bioinformatics2006，64，： | 1 |
| 19 | HUPO Plasma Proteome Project specimen collection and handling:Towards the standardization of parameters for plasma proteome samples显示文摘 | RaiA J Gelfand CA Haywood BC | 2005 | Proteomics2005，5，13： | 1 |
| 20 | Presentation and clinical pro- gression of pseudohypoparathyroidism with multi-hormone resistance and Albright hereditary osteodystrophy : a case series 显示文摘 | Gelfand IM Eugster EA DiMeglio LA | 2006 | J Pediatr2006，149，6： | 1 |
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