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| 1 | Molecular changes in hepatic metabolism and transport incirrhosis and their functional importance显示文摘Liver cirrhosis is the common endpoint of many hepatic diseases and represents a relevant risk for liver failure and hepatocellular carcinoma.The progress of liver fibrosis and cirrhosis is accompanied by deteriorating liver function.This review summarizes the regulatory and functional changes in phase Ⅰ and phaseⅡmetabolic enzymes as well as transport proteins and provides an overview regarding lipid and glucose metabolism in cirrhotic patients.Interestingly,phase Ⅰ enzymes are generally down regulated transcriptionally,while phaseⅡenzymes are mostly preserved transcriptionally but are reduced in their function.Transport proteins are regulated in a specific way that resembles the molecular changes observed in obstructive cholestasis.Lipid and glucose metabolism are characterized by insulin resistance and catabolism,leading to the disturbance of energy expenditure and wasting.Possible non-invasive tests,especially breath tests,for components of liver metabolism are discussed.The heterogeneity and complexity of changes in hepatic metabolism complicate the assessment of liver function in individual patients.Additionally,studies in humans are rare,and species differences preclude the transferability of data from rodents to humans.In clinical practice,some established global scores or criteria form the basis for the functional evaluation of patients with liver cirrhosis,but difficult treatment decisions such as selection for transplantation or resection require further research regarding the application of existing non-invasive tests and the development of more specific tests. | Christoph G Dietrich Oliver Götze Andreas Geier | 2016 | World Journal of Gastroenterology2016，22，1： | 10 |
| 2 | Non-alcoholic fatty liver disease and COVID-19: Harmless companions or disease intensifier?显示文摘The pandemics of coronavirus disease 2019(COVID-19)and non-alcoholic fatty liver disease(NAFLD)coexist.Elevated liver function tests are frequent in COVID-19 and may influence liver damage in NAFLD,while preexisting liver damage from NAFLD may influence the course of COVID-19.However,the prognostic relevance of this interaction,though,is unclear.Obesity is a risk factor for the presence of NAFLD as well as a severe course of COVID-19.Cohort studies reveal conflicting results regarding the influence of NAFLD presence on COVID-19 illness severity.Striking molecular similarities of cytokine pathways in both diseases,including postacute sequelae of COVID-19,suggest common pathways for chronic low-activity inflammation.This review will summarize existing data regarding the interaction of both diseases and discuss possible mechanisms of the influence of one disease on the other. | Christoph G Dietrich Andreas Geier Uta Merle | 2023 | World Journal of Gastroenterology2023，29，2： | 2 |
| 3 | Rcognition sequence of the dam methylase of Escherichia coli K12 and mode of cleavage of Dpn Ⅰ endonucleade显示文摘 | Geier G E Modrich P | 1979 | J Biol Chen1979，254，4： | 1 |
| 4 | Multidrug resis-tance and response to antiretroviral treatment显示文摘 | DIETRICH C G GEIER A MATERN S | 2002 | Lancet2002，359，9323： | 1 |
| 5 | Is there really an increase in non-minimal change nephrotic syndrome in children显示文摘 | FILLER G YOUNG E GEIER P | 2003 | Am J Kidney Dis2003，42，6： | 1 |
| 6 | Accurate cable force determination using ambient vibration measurements显示文摘 | Geier R De Roeck G Flesch R | 2006 | Structure and Infrastructure Engineering2006，2，1： | 1 |
| 7 | Optimal processing of GPS signals显示文摘 | Copps E M Geier G J Fidler W C | 1980 | Journal of the Institute of Navigation1980，27，3： | 1 |
| 8 | Regulation of basolateral organic anion transporters in ethinylestradiol-induced cholestasis in the rat显示文摘 | Geier A Dietrich C G Gerloff T | 2003 | Biochim Biophys Acta2003，1609，1： | 1 |
| 9 | Regulation of basolateral organic anion transporters in ethinylestradiol-induced cholestasis in the rat显示文摘 | Geier A Dietrich C G Gerloff T | 2003 | Biochim Biophys Acta2003，1609，1： | 1 |
| 10 | An efficient one - flask synthesis of N - confused tetraphenyl - porphyrin 显示文摘 | Geier G R Haynes D M Lindsey J S | 1999 | Organic Letters1999，1，9： | 1 |
| 11 | Structure-based ligand discovery for the large-neutral amino acid transporter 1,LAT-1显示文摘 | GEIER E G SCHLESSINGER A FAN H | 2013 | PNAS2013，110，14： | 1 |
| 12 | On the absence of stereoselectivity in the catalytic oxidation of alkenes with a surface-bound men- tall oporphyrin-peptide conjugate显示文摘 | Geier G R Sasaki T | 1999 | Tetrahedron1999，55，： | 1 |
| 13 | A two-phase study evaluating the relationship between Thimerosal-containing vaccine administration and the risk for an autism spectrum disorder diagnosis in the United States显示文摘Background:Autism spectrum disorder(ASD)is defined by standardized criteria of qualitative impairments in social interaction,qualitative impairments in communication,and restricted and stereotyped patterns of behavior,interests,and activities.A significant number of children diagnosed with ASD suffer a loss of previously-acquired skills,which is suggestive of neurodegeneration or a type of progressive encephalopathy with an etiological pathogenic basis occurring after birth.To date,the etiology of ASD remains under debate,however,many studies suggest toxicity,especially from mercury(Hg),in individuals diagnosed with an ASD.The present study evaluated concerns about the toxic effects of organic-Hg exposure from Thimerosal(49.55%Hg by weight)in childhood vaccines by conducting a two-phased(hypothesis generating/hypothesis testing)study with documented exposure to varying levels of Thimerosal from vaccinations.Methods:A hypothesis generating cohort study was undertaken to evaluate the relationship between exposure to organic-Hg from a Thimerosal-containing Diphtheria-Tetanus-acellular-Pertussis(DTaP)vaccine in comparison to a Thimerosal-free DTaP vaccine administered,from 1998 through 2000,for the risk of ASD as reported in the Vaccine Adverse Event Reporting System(VAERS)database(phase I).A hypothesis testing case–control study was undertaken to evaluate the relationship between organic-Hg exposure from Thimerosal-containing hepatitis B vaccines administered at specific intervals in the first six months of life among cases diagnosed with an ASD and controls born between 1991 through 1999 in the Vaccine Safety Datalink(VSD)database(phase II).Results:In phase I,it was observed that there was a significantly increased risk ratio for the incidence of ASD reported following the Thimerosal-containing DTaP vaccine in comparison to the Thimerosal-free DTaP vaccine.In phase II,it was observed that cases diagnosed with an ASD were significantly more likely than controls to receive increased organic-Hg from Thimerosal-containing hepatitis B vaccine administered within the first,second,and sixth month of life.Conclusions:Routine childhood vaccination is an important public health tool to reduce the morbidity and mortality associated with infectious diseases,but the present study provides new epidemiological evidence supporting an association between increasing organic-Hg exposure from Thimerosal-containing childhood vaccines and the subsequent risk of an ASD diagnosis. | David A Geier Brian S Hooker Janet K Kern Paul G King Lisa K Sykes Mark R Geier | 2013 | Translational Neurodegeneration2013，2，1： | 1 |
| 14 | Optimal processing of GPS signals 显示文摘 | COPPS E M GEIER G J FIDLER W C | 1980 | Navigation1980，27，3： | 1 |
| 15 | Microstructure Transition from Lameltar to Compacted Graphite Using Different Modification Agents显示文摘 | Geier G F Bauer W McKay B J | 2005 | Materials Science and Engineering A2005，，： | 1 |
| 16 | Microstructure transition fromlamellartocompactedgraphiteusing differentmodificationagents 显示文摘 | Geier G F Bauer W Mckay B J | 2005 | MaterialsScienceandEngineer ingA2005，，： | 1 |
| 17 | Inflammatory bowel disease: current insights into pathogenesis and new therapeutic options; probiotics, prebiotics and synbiotics显示文摘 | Geier M S Butler R N Howarth G S | 2007 | Int J Food Microbiol2007，115，1： | 1 |
| 18 | I s there really an increase in non-minimal change nephrotic syndrome in children?显示文摘 | Filler G Young E Geier P | 2003 | Am J Kidney Dis2003，42，6： | 1 |
| 19 | A Case-Control Study Evaluating the Relationship Between Thimerosal-Containing Haemophilus influenzae Type b Vaccine Administration and the Risk for a Pervasive Developmental Disorder Diagnosis in the United States 显示文摘 | Geier D A Kern J K King P G | 2015 | Biol Trace Elem Res2015，163，12： | 1 |
| 20 | Accurate cable force determination using ambient vibration measurements 显示文摘 | Geier R De Roeck G Flesch R | 2006 | Structure and Infrastructure Engineering2006，2，1： | 1 |
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