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您的检索式：作者名="Gefei Deng"
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| 1 | Effects of sea level rise on storm surge and waves within the Yangtze River Estuary显示文摘Sea level rise (SLR) can cause water depth increase (WDI) and coastal inundation (CI).By applying the coupled FVCOM + SWAN model,this study investigates the potential impacts of WDI and CI,induced by a 1.0 m SLR,on storm surge and waves within the Yangtze River Estuary.A 1.0 m WDI decreases the maximum storm surge by 0.15 m and increases the maximum significant wave height by 0.35 m.The CI effect size is smaller when compared with WDI.CI decreases the maximum storm surge and significant wave height by 0.04 and 0.07 m,respectively.In the near-shore area,WDI significantly alters the local hydrodynamic environment,thereby stimulating changes in maximum storm surges and wave heights.Low-lying regions are negatively impacted by CI.Conversely,in deep-water areas,the relative change in water depth is minimal and the effect of CI is gradually enhanced.The combined effect of WDI and CI decreases the maximum surge by 0.31 m and increases the maximum significant wave height by 0.21 m.As a result,CI may be neglected when designing deep-water infrastructures.Nonetheless,the complex interactions between adoption and neglect of CI should be simulated to achieve the best seawall flood control standards and design parameters. | Yongming SHEN Gefei DENG Zhihao XU Jun TANG | 2019 | Frontiers of Earth Science2019，13，2： | 3 |
| 2 | Computational investigation on hydrodynamic and sediment transport responses influenced by reclamation projects in the Meizhou Bay,China显示文摘Reclamation projects are the main method of coastal exploitation,and the hydrodynamic environmental effect,together with the sediment transport response of the reclamation project,is important to the project’s site selection and environmental protection.Herein,a 3D numerical model based on the finite volume community ocean model(FVCOM)is applied to simulate the changes in the Meizhou Bay’s hydrodynamic environment and sediment transport after a reclamation project.The reclamation project greatly alters the shape of the shoreline and narrows the bay,leading to a significant change in its hydrodynamic environment and sediment transport.After the project,the clockwise coastal residual current in the corner above the Meizhou Island gradually disappears.An obvious counter-clockwise coastal residual current emerges around the rectangular corner.The tidal prism decreases by 0.65×10^9 and 0.44×10^9 m^3 in the spring and neap tides,respectively.The residence time presents a major increase.These changes lead to the weakening of the water exchange capacity and the reduction of the self-purification capacity of the bay.Currents in the tidal channel weaken,whilst currents in the horizontal channel strengthen.The strength and scope of particle trajectories around the horizontal channel and the Meizhou Island enhance.The suspended sediment concentration(SSC)increases in the majority of the Meizhou Bay but decreases in the lateral bay.The eastern corner of Z2 shows a tendency to erode.The western region of the Meizhou Island,the upper portion of the rectangular corner and the western corner of Z4 show a tendency to deposit.The reclamation project increases the maximum storm surges by 0.06 m and decreases the maximum significant wave heights by 0.09 m. | Gefei Deng Yongming Shen Changping Li Jun Tang | 2020 | Frontiers of Earth Science2020，14，3： | 1 |
| 3 | Novel phthalimides regulating PD-1/PD-L1 interaction as potential immunotherapy agents显示文摘Programmed cell death 1(PD-1)/programmed cell death ligand 1(PD-L1)have emerged as one of the most promising immune checkpoint targets for cancer immunotherapy.Despite the inherent advantages of small-molecule inhibitors over antibodies,the discovery of small-molecule inhibitors has fallen behind that of antibody drugs.Based on docking studies between small molecule inhibitor and PD-L1 protein,changing the chemical linker of inhibitor from a flexible chain to an aromatic ring may improve its binding capacity to PD-L1 protein,which was not reported before.A series of novel phthalimide derivatives from structure-based rational design was synthesized.P39 was identified as the best inhibitor with promising activity,which not only inhibited PD-1/PD-L1 interaction(IC_(50)=8.9 nmol/L),but also enhanced killing efficacy of immune cells on cancer cells.Co-crystal data demonstrated that P39 induced the dimerization of PD-L1 proteins,thereby blocking the binding of PD-1/PD-L1.Moreover,P39 exhibited a favorable safety profile with a LD_(50)>5000 mg/kg and showed significant in vivo antitumor activity through promoting CD8^(+)T cell activation.All these data suggest that P39 acts as a promising small chemical inhibitor against the PD-1/PD-L1 axis and has the potential to improve the immunotherapy efficacy of T-cells. | Chengliang Sun Yao Cheng Xiaojia Liu Gefei Wang Wenjian Min Xiao Wang Kai Yuan Yi Hou Jiaxing Li Haolin Zhang Haojie Dong Liping Wang Chenguang Lou Yanze Sun Xinmiao Yu Hongbin Deng Yibei Xiao Peng Yang | 2022 | Acta Pharmaceutica Sinica B2022，12，12： | 0 |
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