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| 1 | Fecal microbiota transplantation as novel therapy in gastroenterology:A systematic review显示文摘AIM:To study the clinical efficacy and safety of Fecal microbiota transplantation(FMT).We systematically reviewed FMT used as clinical therapy.METHODS:We searched MEDLINE,EMBASE,the Cochrane Library and Conference proceedings from inception to July,2013.Treatment effect of FMT was calculated as the percentage of patients who achieved clinical improvement per patient category,on an intention-to-treat basis.RESULTS:We included 45 studies;34 on Clostridium difficile-infection(CDI),7 on inflammatory bowel disease,1 on metabolic syndrome,1 on constipation,1 on pouchitis and 1 on irritable bowel syndrome(IBS).In CDI 90% resolution of diarrhea in 33 case series(n = 867) was reported,and 94% resolution of diarrhea after repeated FMT in a randomized controlled trial(RCT)(n = 16).In ulcerative colitis(UC) remission rates of 0% to 68% were found(n = 106).In Crohn's disease(CD)(n = 6),no benefit was observed.In IBS,70% improvement of symptoms was found(n = 13).100% Reversal of symptoms was observed in constipation(n = 3).In pouchitis,none of the patients(n = 8) achieved remission.One RCT showed significant improvement of insulin sensitivity in metabolic syndrome(n = 10).Serious adverse events were rare.CONCLUSION:FMT is highly effective in CDI,and holds promise in UC.As for CD,chronic constipation,pouchitis and IBS data are too limited to draw conclusions.FMT increases insulin sensitivity in metabolic syndrome. | Noortje G Rossen John K Mac Donald Elisabeth M de Vries Geert R D'Haens Willem M de Vos Erwin G Zoetendal Cyriel Y Ponsioen | 2015 | World Journal of Gastroenterology2015，21，17： | 41 |
| 2 | Prediction of delayed graft function using different scoring algorithms: A single-center experience显示文摘AIM To compare the performance of 3 published delayed graftfunction(DGF) calculators that compute the theoretical risk of DGF for each patient.METHODS This single-center,retrospective study included 247 consecutive kidney transplants from a deceased donor.These kidney transplantations were performed at our institution between January 2003 and December 2012.We compared the occurrence of observed DGF in our cohort with the predicted DGF according to three different published calculators. The accuracy of the calculators was evaluated by means of the c-index(receiver operating characteristic curve).RESULTS DGF occurred in 15.3% of the transplants under study.The c index of the Irish calculator provided an area under the curve(AUC) of 0.69 indicating an acceptable level of prediction,in contrast to the poor performance of the Jeldres nomogram(AUC = 0.54) and the Chapal nomogram(AUC = 0.51). With the Irish algorithm the predicted DGF risk and the observed DGF probabilities were close. The mean calculated DGF risk was significantly different between DGF-positive and DGF-negative subjects(P < 0.0001). However,at the level of the individual patient the calculated risk of DGF overlapped very widely with ranges from 10% to 51% for recipients with DGF and from 4% to 56% for those without DGF.The sensitivity,specificity and positive predictive value of a calculated DGF risk ≥ 30% with the Irish nomogram were 32%,91% and 38%. CONCLUSION Predictive models for DGF after kidney transplantation are performant in the population in which they were derived,but less so in external validations. | Magda Michalak Kristien Wouters Erik Fransen Rachel Hellemans Amaryllis H Van Craenenbroeck Marie M Couttenye Bart Bracke Dirk K Ysebaert Vera Hartman Kathleen De Greef Thiery Chapelle Geert Roeyen Gerda Van Beeumen Marie-Paule Emonds Daniel Abramowicz Jean-Louis Bosmans | 2017 | World Journal of Transplantation2017，7，5： | 3 |
| 3 | Neuroimaging standards for research into small vessel disease and its contribution to ageing and neurodegeneration显示文摘 | Joanna M Wardlaw Eric E Smith Geert J Biessels Charlotte Cordonnier Franz Fazekas Richard Frayne Richard I Lindley John T O’Brien Frederik Barkhof Oscar R Benavente Sandra E Black Carol Brayne Monique Breteler Hugues Chabriat Charles DeCarli Frank-Erik de | 2013 | Lancet Neurology2013，，8： | 2 |
| 4 | Systemic release of endotoxins induced by gentle mastication: Association with periodontitis se- verity显示文摘 | Geerts SO Nys M De MP | 2002 | J Periodontol2002，73，1： | 1 |
| 5 | A 14-bit intrinsic accuracy Q2 random walk CMOS DAC显示文摘 | Geert A Van der Plas M Vandenbussche J | 1999 | IEEE J Sol Sta Circ1999，34，12： | 1 |
| 6 | Traumatic aortic rupture,30 years of experience显示文摘 | Cindy M Sabrina H Kim D Geert M Inge F | | 0，，： | 1 |
| 7 | Neonatal expo- sure to brominated flame retardant BDE-47 reduces long-term potentiation and postsynaptic protein levels in mouse hippocam- pus 显示文摘 | Dingemans M Dingemans ML Geert MJ | 2007 | Environmental Health Perspectives2007，115，6： | 1 |
| 8 | Large scale production of recombinant human lactoferrin in the milk of transgenic cows 显示文摘 | VAN BERKEL P H WELLING M M GEERTS M | 2002 | Nat Biotechnol2002，20，5： | 1 |
| 9 | Three Conceptions of Quantified Societal Risk 显示文摘 | Stallen P J M Geerts R Vrijling H K | 1996 | Risk Analysis1996，16，5： | 1 |
| 10 | Percutaneous absorption of indomethaein from transparent oil/water gels in rabbit显示文摘 | VOS D F MUYNEK D C GEERTS M | 1991 | Pharm Pharmacol1991，43，4： | 1 |
| 11 | A genetic input selection methodology for identification of the cleaning process on a combine harvester,Part Ⅱ:selection of relevant input variables for identification of material other than grain (MOG)content in the grain bin显示文摘 | Geert C Wouter S Bart M | | 0，，： | 1 |
| 12 | Systemic release of endotoxins induced by gentle mastication:association with periodontitis severity显示文摘 | Geerts SO Nys M De MP | 2002 | J Periodontol2002，73，1： | 1 |
| 13 | Agro-climatic suitability mapping for crop production in the Bolivian Altiplano:a case study for quinoa显示文摘 | Geerts S Raes D Garcia M | 2006 | Agricultural and Forest Meteorology2006，13，9： | 1 |
| 14 | Comparison of threeresearch models of portal hypertension in mice: macroscopic,histological and portal pressure evaluation 显示文摘 | Geerts AM Vanheule E Praet M | 2008 | Int J Exp Pathol2008，89，： | 1 |
| 15 | A prospective study of venous thromboembolism after major trauma显示文摘 | Geerts W H Code K I Jay R M | 1994 | N Engl J Med1994，331，24： | 1 |
| 16 | Identification of the cleaning process on combine harvesters,part II:a fuzzy model for prediction of the sieve losses显示文摘 | Geert C Wouter S Bart M | | 0，，02： | 1 |
| 17 | Methanol degradation in granular sludge reactors at sub-optimal metal concentrations:role of iron,nickel and cobalt显示文摘 | ZANDVOORT M H GEERTS R LETTINGA G | 2003 | Enzyme Microbial Technol2003，33，23： | 1 |
| 18 | Glycosylated and unglycosylated human lactoferrins both bind iron and show identical affinities towards human lysozyme and bacterial lipopolysaccharide, but differ in their susceptibilities towards tryptic proteolysis显示文摘 | Berkel P H van Geerts M E Veen H A van | 1995 | Biochem J1995，312，1： | 1 |
| 19 | Simulating yield response of Quinoa to water availability with AquaCrop显示文摘 | Geerts S Rase D Garcia M | 2009 | Agron J2009，101，3： | 1 |
| 20 | A genetic input selection methodology for identification of the cleaning process on a combine harvester,Part I:Selection of relevant input variables for identification of the sieve losses显示文摘 | Geert C Wouter S Bart M | | 0，，02： | 1 |
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