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| 1 | Targeting Wnt/β-catenin pathway in hepatocellularcarcinoma treatment显示文摘Hepatocellular carcinoma(HCC) is one of the most common causes of cancer-related death worldwide. Liver cancer is generally related to hepatitis B or Cinfection and cirrhosis. Usually, patients with HCC are asymptomatic and are diagnosed at late stages when surgical treatment is no longer suitable. Limited treatment options for patients with advanced HCC are a major concern. Therefore, there is an urge for finding novel therapies to treat HCC. Liver cancer is highly heterogeneous and involved deregulation of several signaling pathways. Wnt/β-catenin pathway is frequently upregulated in HCC and it is implicated in maintenance of tumor initiating cells, drug resistance, tumor progression, and metastasis. A great effort in developing selective drugs to target components of the β-catenin pathway with anticancer activity is underway but only a few of them have reached phase Ⅰ clinical trials. We aim to review the role of β-catenin pathway on hepatocarcinogenesis and liver cancer stem cell maintenance. We also evaluated the use of small molecules targeting the Wnt/β-catenin pathway with potential application for treatment of HCC. | valery vilchez lilia turcios francesc marti roberto gedaly | 2016 | World Journal of Gastroenterology2016，22，2： | 51 |
| 2 | Role of surgery and transplantation in the treatment of hepatic metastases from neuroendocrine tumor显示文摘Neuroendocrine tumors(NET) are a heterogeneous group of cancers, with indolent behavior. The most common primary origin is the gastro-intestinal tract but can also appear in the lungs, kidneys, adrenals, ovaries and other organs. In general, NET is usually discovered in the metastatic phase(40%-80%). The liver is the most common organ involved when metastases occur(40%-93%), followed by bone(12%-20%) and lung(8%-10%).A number of different therapeutic options are available for the treatment of hepatic metastases including surgical resection, transplantation, ablation, trans-arterial chemoembolization, chemotherapy and somatostatin analogues. Recently, molecular targeted therapies have been used, usually in combination with other treatment options, to improve outcomes in patients with metastases. This article emphasizes on the role of surgery in the treatment of liver metastases from NET. | Sayee Sundar Alagusundaramoorthy Roberto Gedaly | 2014 | World Journal of Gastroenterology2014，20，39： | 7 |
| 3 | PKI-587 and Sorafenib Targeting PI3K/AKT/mTOR and Ras/Raf/MAPK Pathways Synergistically Inhibit HCC Cell Proliferation显示文摘 | Roberto Gedaly Paul Angulo Jonathan Hundley Michael F. Daily Changguo Chen B. Mark Evers | 2012 | Journal of Surgical Research2012，，2： | 3 |
| 4 | SSJD14080400004873显示文摘 | Roberto Galuppo Dinesh Ramaiah Oscar Moreno Ponte Roberto Gedaly | 2014 | Digestive Diseases and Sciences2014，，8： | 2 |
| 5 | Distal splenorenal shunt: role, indications, and utility in the era of liver transplan- tation显示文摘 | Jenkins RL Gedaly R Pomposelli JJ | 1999 | Arch Surg1999，134，： | 1 |
| 6 | Targeting the Wnt/βcatenin signaling pathway in liver cancer stem cells and hepatocellular carcinoma cell lines with FH535显示文摘 | Gedaly R Galuppo R Daily MF | 2014 | PLoS One2014，9，99： | 1 |
| 7 | PI-103 and sorafenib inhibit hepatocellular carcinoma cell proliferation by blocking Ras/Raf/MAPK and PI3K/AKT/mTOR pathways显示文摘 | Gedaly R Angulo P Hundley J | 2010 | Anticancer Res2010，30，12： | 1 |
| 8 | PI - 103 and so- rafenib inhibit hepatocellular carcinoma cell proliferation by bloc- king Ras/Raf/MAPK and PI3 K/AKT/mTOR pathways显示文摘 | GEDALY R ANGULO P HUNDLEY J | 2010 | Anti- cancer Res2010，30，12： | 1 |
| 9 | Cavemous Hemangioma of the Liver Anatomic Resection vs Enucleation 显示文摘 | Gedaly R Pomposclli J J Pomfret E A W | 1999 | Arch Surg1999，134，： | 1 |
| 10 | PKI-587 and sorafenib tar geting PI3K/AKT/mTOR and Ras/Raf/MAPK pathways syn- erqistically inhibit HCC cell proliferation显示文摘 | Gedaly R Angulo P Hundley J | 2012 | 176(2) : 542- 5482012，176，2： | 1 |
| 11 | Cavernous hemangioma of the liver: anatomic resection vs enucleation 显示文摘 | Gedaly R Pomposelli JJ Pomfret EA | 1999 | Arch Surg1999，134，4： | 1 |
| 12 | Liver trans- plantation for the treatment of liver metastases from neuroendocrine tumors: an analysis of UNOS database 显示文摘 | Gedaly R Daily M F Davenport D | 2011 | Arch Surg2011，146，： | 1 |
| 13 | PI - 103 and sorafenib inhibit hepatocellular carcinoma cell proliferation by blocking Ras/Raf/MAPK and PI3K/AKT/mTOR pathways 显示文摘 | Gedaly R Angulo P Hundley J | 2010 | Anticaneer Res2010，30，12： | 1 |
| 14 | Cavernous hemangioma of the liver anatomic resection vs enucleation 显示文摘 | Roberto Gedaly James J Pomposelli Elizabeth A | 1999 | Arch Surg1999，134，4： | 1 |
| 15 | Pain, sleep disturbance, and fatigue in children with leukemia and their parents: A pilot study显示文摘 | Gedaly - Duff V Lee KA Nail L | 2006 | Oncol Nurs Forum2006，33，3： | 1 |
| 16 | The Role of Bridging Therapy in Hepatocellular Carcinoma显示文摘 | Roberto Galuppo Angie McCall Roberto Gedaly Daisuke Morioka | 2013 | International Journal of Hepatology2013，，： | 1 |
| 17 | Differences in symp- tom occurrence, frequency, intensity, and distress in adolescents prior to and one week after the administration of chemotherapy显示文摘 | Walker A J Gedaly - Duff V Miaskowski C | 2010 | J Pediatr Oncol Nurs2010，27，5： | 1 |
| 18 | P1-103 and sorafenib inhibit hepatocellular carcinoma cell proliferation by blocking Ras/Raf/MAPK and PI 3 K/AKT/mTOR pathways显示文摘 | GEDALY R ANGULO P HUNDLEY J | 2010 | Anticancer Res2010，30，12： | 1 |
| 19 | Cavernous hemangioma of the liver anatomic resection vs enucleation 显示文摘 | Gedaly R PomposelliJJ Pomfret EA | 1999 | Arch Surg1999，134，4： | 1 |
| 20 | Targeting the Wnt/β-Catenin Signaling Pathway in Liver Cancer Stem Cells and Hepatocellular Carcinoma CellLines with FH535显示文摘 | Gedaly R Galuppo R Daily MF | 2014 | PLoS One2014，9，99： | 1 |
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