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| 1 | Effect of nutritional counselling on hepatic,muscle and adipose tissue fat content and distribution in non-alcoholic fatty liver disease显示文摘AIM: To assess the effectiveness of the current UK clinical practice in reducing hepatic fat (IHCL). METHODS: Whole body MRI and 1H MRS were obtained, before and after 6 mo nutritional counselling, from liver, soleus and tibialis muscles in 10 subjects with non-alcoholic fatty liver disease (NAFLD). RESULTS: A 500 Kcal-restricted diet resulted in an average weight loss of 4% (-3.4 kg,) accompanied by significant reductions in most adipose tissue (AT) depots, including subcutaneous (-9.9%), abdominal subcutaneous (-10.2%) and intra-abdominal-AT (-11.4%). Intramyocellular lipids (IMCL) were significantly reduced in the tibialis muscle (-28.2%). Decreases in both IHCL (-39.9%) and soleus IMCL (-12.2%) content were also observed, although these were not significant. Several individuals showed dramatic decreases in IHCL, while others paradoxically showed increases in IHCL content. Changes in body composition were accompanied by improvements in certain liver function tests: serum aspartate aminotransferase (AST) and alanine aminotransferase (ALT). Significant correlations were found between decreases in IHCL and reductions in both intra-abdominal and abdominal subcutaneous AT. Improvements in liver function tests were associated with reductions in intra-abdominal AT, but not with changes in IHCL. CONCLUSION: This study shows that even a very modest reduction in body weight achieved through lifestyle modification can result in changes in body fat depots and improvements in LFTs. | E Louise Thomas Audrey E Brynes Gavin Hamilton Nayna Patel Adam Spong Robert D Goldin Gary Frost Jimmy D Bell Simon D Taylor-Robinson | 2006 | World Journal of Gastroenterology2006，12，36： | 13 |
| 2 | A STUDY OF STRUCTURE AND PROPERTY CHANGES OF BIODEGRADABLE POLYGLYCOLIDE AND POLY(GLYCOLIDE-co-LACTIDE)FIBERS DURING PROCESSING AND IN VITRO DEGRADATION显示文摘Structure and properties of bioabsorbable polyglycolide (PGA) and poly(glycolide-co-lactide) (PGA-co-PLA)fibers were investigated during several industrial processing stages and in vitro degradation by means of wide-angle X-ray diffraction (WAXD), dynamic mechanical analysis (DMA) and mechanical property tests. In the orientation stage, the PGA fibers were found to have higher degrees of crystallinity than corresponding PGA-co-PLA samples produced under similar conditions. In the hot-stretching and post-annealing stages, after fibers were braided, PGA samples were found to gain more crystallinity and higher Tg than PGA-co-PLA samples. The higher crystallinity in PGA fibers resulted in a slower rate of degradation. DMA results showed that a great deal of internal stress that was built during orientation and hot-stretching stages was released in the post-annealing stage for all PGA and PGA-co-PLA samples. During earlier stages ofin vitro degradation, both PGA and PGA-co-PLA samples exhibited the typical cleavage-induced crystallization mechanism. The heat shrinkage in the glass transition area was found to disappear after 6-8 days of degradation for all PGA and PGA-co-PLA samples, indicating the amorphous portions of the polymers lost orientation after a short period in the buffer solution, most likely due to relaxation of the cleaved chains. | Bruce X.Fu Benjamin S.Hsiao Gavin Chen Jack Zhou Susan Lin Jenny Yuan Ilya Koyfman Dennis D Jamiolkowski Edward Dormier | 2003 | Chinese Journal of Polymer Science2003，21，2： | 9 |
| 3 | Foxp3 programs the development and function of CD4 + CD25 + regulatory T cells显示文摘 | Gavin M A Rudensky A Y | 2003 | Nature Immunology2003，4，4： | 1 |
| 4 | FoxP3 programs the development and function of CD4+CD25+ regulatory T cells显示文摘 | Fontenot J D Gavin M A Rudensky A Y | 2003 | Nat Immunol2003，4，4： | 1 |
| 5 | Foxp3 pro- grams the development and function of CD4 + CD25 + reg- ulatory T cells显示文摘 | Fontenot J D Gavin M A Rudensky A Y | 2003 | Nat Immunol2003，4，4： | 1 |
| 6 | Centering decisions in hier- archical linear models: implications for research in organizations 显示文摘 | Hofmann D A Gavin M B | 1998 | Journal of Management1998，24，5： | 1 |
| 7 | Outcomes of the Arterial Switch Operation for Transposition of the Great Arteries: 25 Years of Experience显示文摘 | Tyson A. Fricke Yves d’Udekem Malcolm Richardson Clarke Thuys Mithilesh Dronavalli James M. Ramsay Gavin Wheaton Leeanne E. Grigg Christian P. Brizard Igor E. Konstantinov | 2012 | The Annals of Thoracic Surgery2012，，1： | 1 |
| 8 | Foxp3 programs the development and function of CD4^+ CD25^+ regulatory T cells 显示文摘 | Fontenot J D Gavin M A Rudensky A Y | 2003 | Nat Immunol2003，4，： | 1 |
| 9 | Foxp3 programs the development and function of CD4+CD25+ regulatory T cells显示文摘 | Fontenot J D Gavin M A Rudensky A Y | 2003 | Nat Immunol2003，4，4： | 1 |
| 10 | Pigmented contact dermatitis due to kojic acid: A paradoxical side effect of a skin lightener 显示文摘 | GARCIA - GAVIN J GONZALEZ - VILAS D FERNANDEZ - REDONDO V | 2010 | Contact Dermatitis2010，62，1： | 1 |
| 11 | Centering decisions in hierarchical linearmodels: Implications for research in organizations显示文摘 | Hofmann D A Gavin M B | 1998 | Journal ofManagement1998，24，5： | 1 |
| 12 | Time,Teams,and Task Performance:Changing Effects of Surface and Deep Level Diversity on Group Functioning显示文摘 | Harrison D A K H Price J H Gavin A T Florey | 2002 | Academy of Management Journal2002，45，： | 1 |
| 13 | Foxp3 programs the development and function of CD4 + CD25 + regulatory T cells显示文摘 | Gavin M A Rudensky A Y | 2003 | Nat Immunol2003，4，4： | 1 |
| 14 | Foxp3 programs the de- velopment andfunction of CD4+CD25 regulatory T cells显示文摘 | Fontenot J D Gavin M A Rudensky A Y | 2003 | Nat Im- munol2003，4，4： | 1 |
| 15 | Foxp3 programs the development and function of CD4^+CD25^+ regulatory T cells显示文摘 | Fontenot J D Gavin M A Rudensky A Y | 2003 | Nat humunol2003，4，4： | 1 |
| 16 | Hepatotoxicity in an African antiretroviral therapy cohort: the effect of tuberculosis and hepatitis B显示文摘 | Christopher J Hoffmann Salome Charalambous Chloe L Thio Desmond J Martin Lindiwe Pemba Katherine L Fielding Gavin J Churchyard Richard E Chaisson Alison D Grant | 2007 | AIDS2007，，10： | 1 |
| 17 | Foxp3 pro- grams the development and function of CD4 + CD25 + regulatory T cells显示文摘 | Fontenot J D Gavin M A Rudensky A Y | 2003 | Nat Immunol2003，4，4： | 1 |
| 18 | Lung function prediction equations derived from health South African gold miners显示文摘 | Eva H Gavin C Rob D | 2000 | Occup Environ Med2000，57，： | 1 |
| 19 | Pathologic basic of veter- inary disease显示文摘 | Mc Gavin M D Zachary J F | 2007 | Can Vet J2007，48，7： | 1 |
| 20 | Safety and efficacy of ketamine sedation for infant flexible fiberoptic bronchoscopy显示文摘 | JOHN W BERKENBOSCH M D GAVIN R | 2004 | Chest2004，125，： | 1 |
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