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| 1 | Exocrine pancreatic function assessed by secretin cholangio-Wirsung magnetic resonance imaging显示文摘BACKGROUND:Magnetic resonance cholangiopancreato-graphy (MRCP) is useful to assess exocrine pancreatic function by combining rapid imaging acquisition with the administration of secretin, a gastrointestinal hormone that stimulates the secretion of bile and pancreatic juice. However, extensive data on this method are lacking. This study aimed to determine whether MRCP with secretin administration is able to simultaneously detect alterations of both the pancreatic ducts and exocrine pancreatic function. METHODS:All subjects older than 18 years who underwent magnetic resonance imaging (MRI) and cholangio-Wirsung magnetic resonance imaging (CWMRI) for suspicion of benign or malignant pancreatic diseases from January 2006 to December 2006 were enrolled in the study. MRI and CWMRI were carried out using a dedicated apparatus. RESULTS:Eighty-seven patients (46 males, 41 females, mean age 59.7±14.6, range 27-87 years) were enrolled. Of the 87 patients, 39 had a normal pancreas on imaging, 20 had an intrapapillary mucinous tumor (IPMT), and the rest had chronic pancreatitis (7), serous cystadenoma (6), a previous attack of acute biliary pancreatitis (5), congenital ductal abnormalities (5), mucinous cystadenoma (3), previous pancreatic head resection for autoimmune pancreatitis (1), or cholangiocarcinoma (1). Morphologically, we found two pseudocysts (one of the 7 patients with chronic pancreatitis, and one of the 5 patients after an attack of acute pancreatitis;the latter pseudocyst communicated with the main pancreatic duct). Calcifications were found in 3 of the 7 patients with chronic pancreatitis. All patients with IPMT and mucinous cystadenoma and 3 patients with serous cystadenoma were histologically confirmed. The remaining patients were followed up adequately to confirm the diagnosis by imaging. According to the Matos criteria, 73 patients (83.9%) were of grade 3, 8 grade 2, 4 grade 1, and 2 grade 0. The only pancreatic diseases which impaired the exocrine pancreatic secretion stimulated by secretin were chronic pancreatitis (57.1% of the patients, grade 0-1) and the IPMT mixed type in 2 of the 4 patients was grade 1. CONCLUSION:Secretin MRCP is a useful technique to simultaneously detect the presence of alterations of the pancreatic ducts and exocrine pancreatic function. | Lucia Calculli Raffaele Pezzilli Marta Fiscaletti Riccardo Casadei Carla Brindisi Giampaolo Gavelli | 2008 | Hepatobiliary & Pancreatic Diseases International2008，7，2： | 5 |
| 2 | Application of CFD (Fluent) to LNG spills into geometrically complex environments显示文摘 | Gavelli F Bullister E Kytomaa H | 2008 | Journal of Hazardous Materials2008，159，1： | 1 |
| 3 | Evaluating the po- tential for overpressures from the ignition of an LNG vapor cloud during of loading显示文摘 | Filippo Gavelli Scott G Davis Olav R Hansen | 2011 | Journal of Loss Prevention in the Process In- dustries2011，，24： | 1 |
| 4 | Technique of hepatic vascular exclusion for extensive resection 显示文摘 | Huguet C Addario - Chieco P Gavelli A | 1992 | Am J Surg1992，163，6： | 1 |
| 5 | Application of CFD (Fluent) to LNG spills into geometrically complex environments显示文摘 | GAVELLI F BULLISTER E EKYTOMAA H | 2008 | Journal of Hazardous Materials2008，159，： | 1 |
| 6 | Computational fluid dynamics simulation of fog clouds due to ambient air vaporizers显示文摘 | Gavelli F | 2010 | Journal of Loss Prevention in the Process Industries2010，23，6： | 1 |
| 7 | Plasmidic CpG sequences induce tumor microenvironment modifications in a rat liver metastasis model 显示文摘 | BERTIN S ANJUERE F GAVELLI A | 2008 | Int J Mol Med2008，21，3： | 1 |
| 8 | Liver ischemia for hepatic resection: where is the limit 显示文摘 | Huguet C Gavelli A Chieco PA | 1992 | Surgery1992，111，3： | 1 |
| 9 | Validation of FLACS against experimental data sets from the model evaluation database for LNG vapor dispersion显示文摘 | HANSEN R GAVELLI F ICHARD M | 2010 | Journal of Loss Prevention in the Process Industries2010，23，6： | 1 |
| 10 | Thoracic complications in uremic patients and in patients undergoing dialytic treatment state of the art显示文摘 | Gavelli G Zompatorii I | 1997 | Eur Radio1997，7，5： | 1 |
| 11 | Thoracic complications in uremic patients and in patients undergoing dialytic treatment: state of the art显示文摘 | G. Gavelli M. Zompatori | 1997 | European Radiology1997，，5： | 1 |
| 12 | Application of CFD(Fluent)to LNG spills into geometrically complex environments显示文摘 | Gavelli Filippo Bullister Edward Kytomaa Harri | 2008 | Journal of Hazardous Materials2008，11，1： | 1 |
| 13 | Technique of hepatic vascular exclusion for extensive liver resection显示文摘 | Huguet C Addario-chieco P Gavelli A | 1992 | Am J surg1992，163，4： | 1 |
| 14 | Effects of guided random sampling of TCCs on blood flow values in CT perfusion studies of lung tumors显示文摘 | Gibaldi A Barone D Gavelli G | 2015 | Acad Radiol2015，22，1： | 1 |
| 15 | Application of CFD (Fluent) to LNG spills into geometrically complex environments显示文摘 | Gavelli F Bullister E Kytomaa H | 2008 | Journal of hazardous materials2008，159，1： | 1 |
| 16 | Thoracic complications in uremic patients and in patients undergoing dialytic treatment:state of the art显示文摘 | Gavelli G Zompatori M | 1997 | Eur Radiol1997，7，5： | 1 |
| 17 | Validation of FLACS against experimental data sets from the model evaluation database for LNG vapor dispersion 显示文摘 | HANSEN O R GAVELLI F | 2010 | Journal of Loss Prevention in the Process Industries2010，23，6： | 1 |
| 18 | Subcutaneous or intrahepatic injection of suicide gene modified tumour cells induces a systemic antitumour response in a metastatic model of colon carcinoma in rats显示文摘 | Pierrefite - Carle V Baque P Gavelli A | 2002 | Gut2002，50，3： | 1 |
| 19 | Naked DNA injection for liver metastases treatment in rats显示文摘 | Baque P Pierrefite-Carle V Gavelli A | 2002 | Hepatology2002，35，5： | 1 |
| 20 | Subcutaneous or intrahepatic injection of suicide gene modified tumour cells induces a systemic antitumour response in a metastatic model of colon carcinoma in rats显示文摘 | Pierrefite-Carle V Baque P Gavelli A | 2002 | Gut2002，50，3： | 1 |
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