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| 1 | Potential implications of Helicobacter pylori-related neutrophil-activating protein显示文摘Helicobacter pylori (H.pylori) virulence factors promote the release of various chemoattractants/inflammatory mediators,including mainly the neutrophilattractant chemokine interleukin-8 and neutrophilactivating protein (NAP),involved in H.pylori-induced gastric pathologies.Co-administration of Chios mastic gum (CMG),which inhibits H.pylori NAP,with an H.pylori eradication regimen might add clinical benefits against H.pylori-related gastric pathologies,but possibly not CMG as main therapy.Although H.pylori NAP and other H.pylori-related cytotoxins [i.e.,vaculating cytotoxin (VacA)] appear to play a major role in generating and maintaining the H.pylori-associated gastric inflammatory response and H.pylori NAP is a promising vaccine candidate against H.pylori infection (H.pylori-I),concerns regarding its potential drawbacks,particularly neurogenic ones,due to possible crossmimicry,should be considered.Possible cross-mimicry between H.pylori NAP and/or bacterial aquaporin (AQP) and neural tissues may be associated with the anti-AQP-4 antibody-related neural damage in multiple sclerosis (MS)/neuromyelitis optica patients.Moreover,the sequence homology found between H.pylori VacA and human Na+/K+-ATPase A subunit suggests that antibodies to VacA involve ion channels in abaxonal Schwann cell plasmalemma resulting in demyelination in some patients.A series of factors have been implicated in inducing blood-brain barrier (BBB) disruption,including inflammatory mediators (e.g.,cytokines and chemokines induced by H.pylori-I) and oxidative stress.BBB disruption permits access of AQP4-specific antibodies and T lymphocytes to the central nervous system,thereby playing a major role in multiple sclerosis pathogenesis.Relative studies show a strong association between H.pylori-I and MS.H.pylori-I induces humoral and cellular immune responses that,owing to the sharing of homologous epitopes (molecular mimicry),cross-react with components of nerves,thereby contributing and perpetuating neural tissue damage.Finally,H.pylori NAP also plays a possible pathogenetic role in both gastric and colon oncogenesis. | Jannis Kountouras Christos Zavos Georgia Deretzi Emmanuel Gavalas Dimitrios Chatzopoulos Panagiotis Katsinelos Elena Tsiaousi Stergios Gagalis Stergios A Polyzos Ioannis Venizelos | 2012 | World Journal of Gastroenterology2012，18，5： | 5 |
| 2 | Development Platforms for Mobile Applications: Status and Trends显示文摘 | Gavalas Damianos Economou Daphne | 2011 | IEEE Software2011，，1： | 2 |
| 3 | Advanced network monitoring applications based on mobile/intelligent agent technology显示文摘 | Gavalas D Greenwood D | 2000 | Computer Communications2000，，23： | 2 |
| 4 | Eradication of Helicobacter pylori may be beneficial in the management of Alzheimer’s disease显示文摘 | Jannis Kountouras Marina Boziki Emmanuel Gavalas Christos Zavos Nikolaos Grigoriadis Georgia Deretzi Dimitrios Tzilves Panagiotis Katsinelos Magda Tsolaki Dimitrios Chatzopoulos Ioannis Venizelos | 2009 | Journal of Neurology2009，，5： | 2 |
| 5 | Biodegradation of phthalate esters during the mesophilic anaerobic digestion of sludge显示文摘 | ALATRISTE-MONDRAGON F IRANPOUR R | 2003 | Chemosphere2003，52，： | 1 |
| 6 | Mapping of melanin-concentrating hormone receptor 1 B cell epitopes predicts two major binding sites for vitiligo patient autoantibodies显示文摘 | Gavalas NG Gottumukkala RV Gawkrodger DJ | 2009 | Exp Dermatol2009，18，： | 1 |
| 7 | Surface Seeding in ZSM-5 Membrane Perva- poration显示文摘 | Lai R Gavalas G R | 1998 | Ind Eng Chem Res1998，37，： | 1 |
| 8 | Ad-vanced network monitoring applications based on mobile/intelligent agent technoloy 显示文摘 | Gavalas D Greenwood D Ghanbari M | 2002 | Computer Communications2002，23，8： | 1 |
| 9 | Anaerobic granular sludge and biofilm reactors显示文摘 | Skiadas I V Gavala H N Schmidt J E Ahring B K | 2003 | Advances in Biochemical Engineering/ Biotechnology2003，82，： | 1 |
| 10 | Statistical and continuum models of fluid-solid reactions in porous media显示文摘 | SAHIMI M GAVALAS G R TSOTSIST T T | 1990 | Chem Eng Sci1990，45，： | 1 |
| 11 | Surface seeding in ZSM-5membrane preparation 显示文摘 | LAI R GAVALAS G R | 1998 | Industrial Engineering and Chemical Research1998，37，： | 1 |
| 12 | The calcium- sensing receptor is a target of autoantibodies in patients with autoimmune polyendocrine syndrome type 1 显示文摘 | Gavalas NG Kemp EH Krohn KJ | 2007 | J Clin Endoerinol Metab2007，92，： | 1 |
| 13 | Effective Determination of Mobile Agent Itineraries for Data Aggregation on Sensor Networks显示文摘 | Konstantopoulos C Mpitziopoulos A Gavalas D | 2010 | IEEE Transactions on Knowledge and Data Engineering2010，22，12： | 1 |
| 14 | Surface seeding in ZSM-5 membrane preparation 显示文摘 | Lai R Gavalas G R | 1998 | Ind Eng Chem Res1998，17，11： | 1 |
| 15 | Autoantibody re-sponses to melanocytes in the depigmenting skin disease vitiligo显示文摘 | Kemp EH Gavalas NG Gawkrodger DJ | 2007 | Autoimmun Rev2007，6，3： | 1 |
| 16 | Virus/allergen interactions in asthma 显示文摘 | Gavala M Bashir H Gern J E | 2013 | Curr Allergy Asthma Rep2013，13，3： | 1 |
| 17 | Autoimmunity as an aetiological factor in vitiligo 显示文摘 | Rezaei N Gavalas NG Weetman AP | 2007 | J Eur Acad Dermatol Venereol2007，21，7： | 1 |
| 18 | Advanced network monitoring applications based on mobile/intelligent agent technology显示文摘 | Gavalas D Greenwood D Ghanbari M | 2002 | Computer Communications2002，23，8： | 1 |
| 19 | Autoimmunity as an aetiological factor in vitiligo显示文摘 | Rezaei N Gavalas NG Weetman AP | 2007 | J Eur Acad Dermatol Venereol2007，21，： | 1 |
| 20 | Mixed-oxide sorbents for high-temperature removal of hydrogen sulfide 显示文摘 | Tamhanker S S Bagajewicz M Gavalas G R | 1986 | Industrial & Engineering Chemistry Process Design and Development1986，25，2： | 1 |
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