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| 1 | 医疗保健数据库的安全信号检测方法概述显示文摘近十年,在药品不良反应监测领域,基于医疗保健数据库的安全信号检测方法受到越来越多的关注,已成为弥补自发报告固有局限性的重要手段。目前数据挖掘方法主要基于比值失衡分析法(disproportionality analysis)、传统药物流行病学设计(如自身对照设计)、序列对称分析(sequence symmetry analysis,SSA)、序贯统计检验(sequential statistical testing)、时序关联规则(temporal association rules)、监督机器学习(supervised machine learning,SML)、树状扫描统计量方法(tree-based scan statistic)等。本文从应用场景和实用性角度对医疗保健数据库中安全信号检测方法及其性能进行介绍。 | 王巍巍 张格 杨智荣 马晓洁 孙凤 詹思延(译) Arnaud M Bégaud B Thurin N | 2021 | 中国循证医学杂志2021，21，4： | 8 |
| 2 | Levels of insecticide resistance to deltamethrin,malathion,and temephos,and associated mechanisms in Aedes aegypti mosquitoes from the Guadeloupe and Saint Martin islands(French West Indies)显示文摘Background:In the Guadeloupe and Saint Martin islands,Aedes aegypti mosquitoes are the only recognized vectors of dengue,chikungunya,and Zika viruses.For around 40 years,malathion was used as a mosquito adulticide and temephos as a larvicide.Since the European Union banned the use of these two insecticide molecules in the first decade of the 21st century,deltamethrin and Bacillus thuringiensis var.israelensis are the remaining adulticide and larvicide,respectively,used in Guadeloupe.In order to improve the management of vector control activities in Guadeloupe and Saint Martin,we investigated Ae.aegypti resistance to and mechanisms associated with deltamethrin,malathion,and temephos.Methods:Ae.aegypti mosquitoes were collected from six different localities of Guadeloupe and Saint Martin.Larvae were used for malathion and temephos bioassays,and adult mosquitoes for deltamethrin bioassays,following World Health Organization recommendations.Knockdown resistance(Kdr)genotyping for V1016I and F1534C mutations,and expression levels of eight enzymes involved in detoxification mechanisms were examined in comparison with the susceptible reference Bora Bora strain.Results:Resistance ratios(RR50)calculated for Ae.aegypti larvae showed high resistance levels to temephos(from 8.9 to 33.1-fold)and low resistance levels to malathion(from 1.7 to 4.4-fold).Adult females displayed moderate resistance levels to deltamethrin regarding the time necessary to affect 50%of individuals,varying from 8.0 to 28.1-fold.Molecular investigations on adult mosquitoes showed high resistant allele frequencies for V1016I and F1534C(from 85 to 96%and from 90 to 98%,respectively),as well as an overexpression of the glutathione S-transferase gene,GSTe2,the carboxylesterase CCEae3a,and the cytochrome genes 014614,CYP6BB2,CYP6M11,and CYP9J23.Conclusions:Ae.aegypti populations from Guadeloupe and Saint Martin exhibit multiple resistance to organophosphates(temephos and malathion),and pyrethroids(deltamethrin).The mechanisms associated with these resistance patterns show strong frequencies of F1534C and V1016I Kdr mutations,and an over-expression of CCEae3a,GSTe2,and four cytochrome P450 genes(014614,CYP9J23,CYP6M11,CYP6BB2).These results will form the baseline for a deeper understanding of the insecticide resistance levels and associated mechanisms of Ae.aegypti populations and will be used to improve vector control strategies in Guadeloupe and Saint Martin. | Daniella Goindin Christelle Delannay Andric Gelasse Cedric Ramdini Thierry Gaude Frederic Faucon Jean-Philippe David Joël Gustave Anubis Vega-Rua Florence Fouque | 2017 | Infectious Diseases of Poverty2017，6，1： | 3 |
| 3 | 牛体内重组牛生长激素(rbST)的快速高灵敏度检测显示文摘重组牛生长激素(rbST)在一些国家和地区常被作为猪或牛的生长促进剂(用于乳牛可以增加牛奶产量),但在欧盟国家,有法规明确禁止生长激素的使用。重组牛生长激素本身是蛋白质,在生物基质中的浓度较低,且样品基质十分复杂,对其进行有效分析还存在一定难度,因而,长久以来其分析方法一直局限为酶联免疫检测法。 | Gaud Pinel Sandrine Roulet-Rochereau ylvain Chéreau Fabrice Monteau Bruno Le Bizec Paul Silcock Marie-Hélène Le Breton | 2010 | 食品安全导刊2010，，8： | 2 |
| 4 | Pharmacokinetics of clopidogrel 显示文摘 | Caplain H Donat F Gaud C | 1999 | Semin Thromb Hemost1999，25，2： | 1 |
| 5 | Xylanases of marine fungi of potential use for biobleaching of paper pulp显示文摘 | Raghukumar C Muraleedharan U Gaud V R | 2004 | J Industrial Microbiol Biotechnol2004，，： | 1 |
| 6 | Organization of stigma surface components in Brassica:A cytochemical study显示文摘 | Gaude T Dumas C | 1986 | Cell Sci1986，82，： | 1 |
| 7 | The Capital Structure of Swiss Companies:an Empirical Analysis Using Dynamic Panel Data显示文摘 | Gaud P Jani E Hoesli M Bender A | 2005 | European Financial Management2005，11，1： | 1 |
| 8 | Role of health education and self-action plan in improving the drug compliance in bronchial asthma显示文摘 | GAUDE G HATTIHOLI J CHAUDHURY A | 2014 | Journal of family medicine and primary care2014，3，1： | 1 |
| 9 | Nebuliz eortieosteroids in the management of acute exacerbation of COPD显示文摘 | Gaude GS Nadagouda S | 2010 | Lung India2010，27，4： | 1 |
| 10 | Defects in mitochondrial metabolism and cancer显示文摘 | Gaude E Frezza C | 2014 | Cancer Metab2014，2，： | 1 |
| 11 | Anti-AChR antibodies,thymic histology,and T cell subsets in myasthenia gravis显示文摘 | Berrih S Morel E Gaud C | 1984 | Neurology1984，34，1： | 1 |
| 12 | Control of the Wnt path- ways by nephrocystin -4 is required for morphogenesis of the zebrafish pronephros显示文摘 | BURCKLE C GAUDE H M VESQUE C | 2011 | Human Molecular Genetics2011，20，13： | 1 |
| 13 | Fertilization in plants: Is calcium a key player显示文摘 | Dumas C Gaude T | 2006 | Seminars in Cell and Development Biology2006，17，2： | 1 |
| 14 | A membrane-like structure on the pollen wall surface in Brassica显示文摘 | Gaude T Dumas C | | 0，，06： | 1 |
| 15 | Stemocleidomastoid island flap preserving the branch from superior thyroid artery for the reconstruction fol- lowing resection of oral cancer显示文摘 | Kumar V Gaud U Shukla M | 2009 | Eur J Surg Oncol2009，35，9： | 1 |
| 16 | Hemoptysis in children 显示文摘 | Gaude GS | 2010 | Indian Pediatr2010，47，3： | 1 |
| 17 | Detection of recombinant bovine somatotropin in milk and effect of industrial processes on its stability显示文摘 | Marie-Hélène Le Breton Andrea Beck-Henzelin Janique Richoz-Payot Sandrine Rochereau-Roulet Gaud Pinel Thierry Delatour Bruno Le Bizec | 2010 | Analytica Chimica Acta2010，，1： | 1 |
| 18 | Nephrocystin -1 and nephrocystin- 4 are required for epithelial morphogenesis and associate with PALS1/PATJ and Pa5 显示文摘 | DELOUS M HELLMAN N E GAUDE H M | 2009 | Hum Mol Genet2009，18，24： | 1 |
| 19 | An extended flamelet model for multiple injections in diesel engines显示文摘 | Felsch C Gauding M Hasse C | 2009 | Proceedings of the Combustion Institute2009，32，2： | 1 |
| 20 | Severe X-linked chronic granulomatous disease in two unrelated females 显示文摘 | Chollet-Martin S Lopez A Gaud C | 2007 | Eur J Pediatr2007，166，2： | 1 |
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