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| 1 | Intragenic antagonistic roles of protein and circRNA in tumorigenesis显示文摘circRNAs arise from back splicing events during mRNA processing, and when deregulated can play an active role in cancer. Here we characterize a new circRNA (circPOK) encoded by the Zbtb7a gene (also kown as POKEMON, LRF) in the context of mesenchymal tumor progression. circPOK functions as a non-coding proto-oncogenic RNA independently and antithetically to its linear transcript counterpart, which acts as a tumor suppressor by encoding the Pokemon transcription factor. We find that circPOK regulates pro-proliferative and pro-angiogenic factors by co-activation of the ILF2/3 complex. Importantly, the expression of Pokemon protein and circRNA is aberrantly uncoupled in cancer through differential post-transcriptional regulation. Thus, we identify a novel type of genetic unit, the iRegulon, that yields biochemically distinct RNA products, circular and linear, with diverse and antithetical functions. Our findings further expand the cellular repertoire towards the control of normal biological outputs, while aberrant expression of such components may underlie disease pathogenesis including cancer. | Jlenia Guarnerio Yang Zhang Giulia Cheloni Riccardo Panella Jesse Mae Katon Mark Simpson Akinobu Matsumoto Antonella Papa Cristian Loretelli Andreas Petri Sakari Kauppinen Cassandra Garbutt Gunnlaugur Petur Nielsen Vikram Deshpande Mireia Castillo-Martin Carlos Cordon-Cardo Spentzos Dimitrios John G. Clohessy Mona Batish Pier Paolo Pandolfi | 2019 | Cell Research2019，29，8： | 15 |
| 2 | Stress,inflammation and cardiovascular disease显示文摘 | Black P H Garbutt L D | 2002 | J Psychosom Res2002，52，： | 1 |
| 3 | Evidence of preference for a higher concentration sucrose solution in alcoholic men 显示文摘 | KAMPOV PAB GARBUTT JC JANOWSKY DS | 1997 | Am J Psychiatry1997，154，2： | 1 |
| 4 | Herbicidal activity of a hydrolysed corn gluten meal on three grass species under controlled environments显示文摘 | LIU D L CHRISTIANS N E GARBUTT J T | 1994 | J Plant Growth Regut1994，13，： | 1 |
| 5 | Reporting and disclosing medical errors :pediatricians' attitudes and be-haviors 显示文摘 | Garbutt J Brownstein DR Klein EJ | 2007 | Arch Pediatr Adolesc Med2007，161，2： | 1 |
| 6 | Effects of Prolonged Strenuous Exercise ( Marathon Running ) on Biochemical and Haematological Markers Used in the Investigation of Patients in the Emergency Department 显示文摘 | Smith J Garbutt G Lopes P | 2004 | Br J Sports Med2004，38，3： | 1 |
| 7 | Sweet liking phenotype alcohol craving and response to naltrexone treatment in alcohol dependence 显示文摘 | GARBUTT JC OSBORNE M GALLOP R | 2009 | Alcohol Alcohol2009，44，3： | 1 |
| 8 | Analysis of the differential response of five annuals to elevated CO2 during growth显示文摘 | Garbutt K Williams W E Bazzaz F A | | Ecology0，71，： | 1 |
| 9 | Brief report :hospitalized patients' attitudes about and participation in error prevention显示文摘 | Waterman A D Gallagher T H Garbutt J | 2006 | J Gen Intern Med2006，21，4： | 1 |
| 10 | Stress, inflammation and cardiovascular disease显示文摘 | Black PH Garbutt LD | 2002 | J Psychosom Res2002，52，1： | 1 |
| 11 | Carbon sequestration and biogeochemical cycling in a sahmarsh subject to coastal managed realignment 显示文摘 | BURDEN A GARBUTT R A EVANS C D | 2013 | Estuarine Coastal and Shelf Science2013，120，： | 1 |
| 12 | Evaluation of an instru- ment to measure nurses~ familiarity with emergency prepared- ness显示文摘 | Garbutt SJ Peltier JW Fitzpatrick JJ | 2008 | Mil Med2008，173，11： | 1 |
| 13 | RNA in- terference in Lepidoptera: An overview of successful studies and implications for experimental design显示文摘 | Terenius O Papanicolaou A Garbutt J S | 2011 | J In- sect Physiol2011，57，2： | 1 |
| 14 | Role of Rubella virus Glycoprotein domains in assembly of virus-like particles显示文摘 | Garbutt M Law LM Chan H | 1999 | Virol1999，73，5： | 1 |
| 15 | Innovative treating processes allow steamfiooding with poor quality oilfield water显示文摘 | Garbutt C F | 2012 | SPE 387992012，，： | 1 |
| 16 | Biogeochemi cal functioning of grazed estuarine tidal marshes along a salin- ity gradient 显示文摘 | DAUSSE A GARBUTT A NORMAN L | 2012 | Estuarine Coastal and Shelf Science2012，100，： | 1 |
| 17 | The analysis of plant growth in ~eological and evolutionary studies显示文摘 | McGraw J B Garbutt K | 1990 | Trends Ecology Evolution1990，5，： | 1 |
| 18 | Demographic growth analysis显示文摘 | McGraw J B Garbutt K | 1990 | Ecology1990，71，3： | 1 |
| 19 | 在发展中的社区推荐急性中耳炎的一线药物治疗:大剂量的阿莫西林是否必要 | Garbutt J. St.Geme Ⅲ J.W. May A. 阿明 | 2005 | 世界核心医学期刊文摘(儿科学分册)2005，0，1： | 1 |
| 20 | RNA interference in Lepidoptera:An overview of successful and unsuccessful studies and implications for experimental design显示文摘 | TERENIUS O PAPANICOLAOU A GARBUTT J S | 2011 | Insect Physiol2011，57，2： | 1 |
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