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| 1 | Molecular classifications of gastric cancers: Novel insights and possible future applications显示文摘Despite some notable advances in the systemic management of gastric cancer(GC), the prognosis of patients with advanced disease remains overall poor and their chance of cure is anecdotic. In a molecularly selected population, a median overall survival of 13.8 mo has been reached with the use of human epidermal growth factor 2(HER2) inhibitors in combination with chemotherapy, which has soon after become the standard of care for patients with HER2-overexpressing GC. Moreover, oncologists have recognized the clinical utility of conceiving cancers as a collection of different molecularlydriven entities rather than a single disease. Several molecular drivers have been identified as having crucial roles in other tumors and new molecular classifications have been recently proposed for gastric cancer as well. Not only these classifications allow the identification of different tumor subtypes with unique features, but also they serve as springboard for the development of different therapeutic strategies. Hopefully, the application of standard systemic chemotherapy, specifictargeted agents, immunotherapy or even surgery in specific cancer subgroups will help maximizing treatment outcomes and will avoid treating patients with minimal chance to respond, therefore diluting the average benefit. In this review, we aim at elucidating the aspects of GC molecular subtypes, and the possible future applications of such molecular analyses. | Silvio Ken Garattini Debora Basile Monica Cattaneo Valentina Fanotto Elena Ongaro Marta Bonotto Francesca V Negri Rosa Berenato Paola Ermacora Giovanni Gerardo Cardellino Mariella Giovannoni Nicoletta Pella Mario Scartozzi Lorenzo Antonuzzo Nicola Silvestris Gianpiero Fasola Giuseppe Aprile | 2017 | World Journal of Gastrointestinal Oncology2017，9，5： | 5 |
| 2 | Leucocyte alkaline phospha- tase identifies terminally differentiated normal neutrophils and its lack in chronic myelogenous leukaemia is not dependent on p210 tyrosine kinase activity 显示文摘 | Dotti G Garattini E Borleri G | 1999 | Br J Haematol1999，105，1： | 1 |
| 3 | Cu2 ZnSnS4 Solar Cells Grown by Sulphurisation of Sputtered Metal Precursors 显示文摘 | Marchionna S Garattini P Le Donne A | 2013 | Thin Solid Films2013，542，： | 1 |
| 4 | Early secondary gingivo-alveolo-plasty in the treatment of unilateral cleft lip and palate patients: 20 years experience 显示文摘 | Meazzini MC Rossetti G Garattini G | 2010 | J Craniomaxillofac Surg2010，38，3： | 1 |
| 5 | Cloning and sequencing of human intestinal alkaline phosphatase cDNA显示文摘 | Berger J Garattini E Hua JC | 1987 | Proc Natl Acad Sci U S A1987，84，： | 1 |
| 6 | Rare diseases:what's next?显示文摘 | Remuzzi G and Garattini S | 2008 | Lancet2008，371，9629： | 1 |
| 7 | Mammalian molybdo-flavoenzymes, an expanding family of proteins: structure, genetics, regulation, function and pathophysiology 显示文摘 | Garattini E Mendel R Romao M J | 2003 | Biochem J2003，372，： | 1 |
| 8 | Early secondary gingivo-alveolo-plasty in the treatment of unilateral cleft lip and palate patients: 20 years experience显示文摘 | Meazzini MC Rossetti G Garattini G | 2010 | J Craniomaxillofac Surg2010，38，3： | 1 |
| 9 | Retinoid related molecules an emerging class of apoptotic agents with promising therapeutic potential in oncology pharmacological activity and mechanisms of action显示文摘 | Garattini E Gianni M Terao M | 2004 | Curr Pharm Des2004，10，4： | 1 |
| 10 | Increasing recognition of the importance of aldehyde oxidase in drug development and discovery 显示文摘 | Garattini E Terao M | 2011 | Drug Metab Rev2011，43，： | 1 |
| 11 | Prevalence of abnormalities in dental structure, position, and eruption pattern in a population of unilateral and bilateral cleft lip and palate patients显示文摘 | Tortora C Meazzini MC Garattini G | 2008 | Cldt Palate Craniofac J2008，45，2： | 1 |
| 12 | Direct Costs of Schizophrenia in Italian Community Psychiatric Services显示文摘 | Garattini L Rossi C Tediosi F | 2001 | mics2001，19，12： | 1 |
| 13 | Pricing and reimbursement of in - patent drugs in seven European countries: A comparative analysis显示文摘 | Garattini L Cornago D De Compadri P | 2007 | Health Policy2007，82，： | 1 |
| 14 | Mammalian aldehyde oxidases: genetics, evolution and biochemistry 显示文摘 | Garattini E Fratelli M Terao M | 2008 | Cell Mol Life Sci2008，65，： | 1 |
| 15 | A model for calculating costs of hospital wards: an Italian experience 显示文摘 | Garattini L Giuliani G Pagano E | 1999 | Journal of Management in Medicine1999，13，2： | 1 |
| 16 | Direct Costs of Schizophrenia and Related Disorders in Italian Community Mental Health Services: a Muhicenter, Prospective 1-Year Followup Study显示文摘 | Garattini L Barbui C Clemente R | 2004 | Schizophrenia Bull2004，30，2： | 1 |
| 17 | Mammalian aldehyde oxidases : genetics, evolution and biochemistry 显示文摘 | GARATTINI E FRATELLI MTERAO M | 2008 | Cell Mol Life Sci2008，65，78： | 1 |
| 18 | Retinoid related molecules an emerging class of apoptotic agents with promising therapeutic potential in oncology pharmacological activity and mechanisms of action显示文摘 | Garattini E Gianni M Terao M | | Curr Pharm Des0，10，4： | 1 |
| 19 | Retinoids as differentiating agents in oncology: a network of interactions with intracellular pathways as the basis for rational therapeutic combinations 显示文摘 | Garattini E Gianni M Terao M | 2007 | Curt Pharm Des2007，13，13： | 1 |
| 20 | Errors in the approval process and post-mai-keting evaluation of drotrecogin alfa (activated) for the treatment of severe sepsis显示文摘 | Poole D Bertolini G Garattini S | 2009 | Lancet Infect Dis2009，9，1： | 1 |
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