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| 1 | A critical regulation of Th2 cell responses by RORa in allergic asthma显示文摘Allergic asthma is a chronic inflammatory disease of the lung and the airway,which is characterized by aberrant type 2 immune responses to otherwise unharmful aeroallergens.While the central role of Th2 cells and type 2 cytokines in the pathogenesis of allergic asthma is well documented,the regulation and plasticity of Th2 cells remain incompletely understood.By using an animal model of allergic asthma in IL-4-reporter mice,we found that Th2 cells in the lung expressed higher levels of Rora than those in the lymph nodes,and that treatment with an RORa agonist SRI 078 resulted in diminished Th2 cell responses in vivo.To determine the T cell-intrinsic role of RORa in allergic asthma in vivo,we established T cell-specific RORa-deficient^(f/f)fyf(Cd4creRora^(f/f))mice.Upon intranasal allergen challenges,Cd4creRora^(f/f)mice exhibited a significantly increased Th2 cells in the lungs and the airway and showed an enhanced eosinophilic inflammation compared to littermate control mice.Studies with Foxp3^(YFP-cre)Rora^(f/f)mice and CD^(8+)T cell depletion showed that the increased Th2 cell responses in the Cd4creRora^(f/f)mice were independent of Treg cells and CD^(8+)T cells.Our findings demonstrate a critical regulatory role of RORa in Th2 cells,which suggest that RORa agonists could be effective for the treatment of allergic diseases. | Jeong-Eun Lee Garam Cho Minkyoung Cho Daehong Kim Mi-Ock Lee Yeonseok Chung | 2021 | Science China(Life Sciences)2021，64，8： | 5 |
| 2 | Detection of Shiga toxin - producing Escherichia coli serotypes O26 : H11, O103 : H2, O111 : H8, O145 : H28, and O157 : H7 in raw - milk cheeses by using multiplex real - time PCR 显示文摘 | Madic J Vingadassalon N de Garam CP | 2011 | Appl Environ Microbiol2011，77，6： | 1 |
| 3 | PerceptionofSelfandOtherinMajorDepression显示文摘 | GaraM A WoolfolkRL CohenBD GoldstonRB AllenLA NovalanyJ | 1993 | JournalofAbnormalPsychology1993，102，1： | 1 |
| 4 | ThePerceptionofSelfandOtherinSchizophrenia显示文摘 | GaraM A RosenbergS MuellerD | 1989 | InternationalJournalofPersonalConstructPsychology1989，2，3： | 1 |
| 5 | Self-complexity:AnAssessmentofConstructValidity显示文摘 | WoolfolkRL GaraM A AllenLA BeaverJD | 2004 | JournalofSocialandClinicalPsychology2004，23，4： | 1 |
| 6 | Antibody-deprendent ceel-mediated cytotoxicity(ADCC) in Parkinson′s disease显示文摘 | Bokor M Farago A Garam J | 1993 | J Neurol Sci1993，115，1： | 1 |
| 7 | Self-complexity,Self-evaluation,andDepression:AnExaminationofformandContentWithintheSelf-schema显示文摘 | WoolfolkRL NovalanyJ GaraM A AllenLA PolinoM | 1995 | JournalofPersonalityandSocialPsychology1995，68，6： | 1 |
| 8 | Self-complexityandthePersistenceofDepression显示文摘 | WoolfolkRL GaraM A AmbroseTK WilliamsJE AllenLA IrvinSL BeaverJD | 1999 | TheJournalofNervousandMentalDisease1999，187，7： | 1 |
| 9 | Duplex real-time PCR detection of type Ill effector tccP and tccP2 genes in pathogenic Escherichia coli and prevalence in raw milk cheeses 显示文摘 | Madic J de Garam CP Brugere H | 2011 | Lett Appl Microbiol2011，52，5： | 1 |
| 10 | Detection of Shiga toxin-producing Escherichia coli serotypes O26:H11,O103:H2,O111:H8,O145:H28,and O157:H7 in raw-milk cheeses by using multiplex real-time PCR显示文摘 | Madic J Vingadassalon N de Garam C P | | 0，，6： | 1 |
| 11 | Simplex and multiplex real-time PCR assays for the dctection of flagellar (H-antigen) fliC alleles and intimin (eae) variants associated with enterohaemorrhagic Escherichia coli(EHEC) serotypes O26:H 11,O103:H2,O 111:H8,O145:H28 and O157:H7显示文摘 | Madic J Peytavin de Garam C Vingadassalon N | | 0，，05： | 1 |
| 12 | γ-CuI Nanocrystals from Self-Assembled Coordination Polymers显示文摘 | Tae Ho Kim Dr Hojin Yang Garam Park | 2010 | Chemistry-an Asian Journal2010，5，2： | 1 |
| 13 | Crystallographic texture evolution in Ti-35Nb alloy deformed by cold rolling 显示文摘 | HAYAMA A 0 F LOPES J F S C GOMES DA SILVA M J ABREU H F G GARAM R | 2014 | Materials and Design2014，60，： | 1 |
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