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| 1 | Qi-Qin Accretionary Belt in Central China Orogen: accretion by trench jam of oceanic plateau and formation of intra-oceanic arc in the Early Paleozoic Qin-Qi-Kun Ocean显示文摘Most orogenic belts have experienced a complex accretionary process with multiple episodes of sea?oor subduction and trench retreat.This accretionary process is important in continenta development and growth[1,2].Three giant orogens extend in China,e.g.,the Central Asian Orogen in the north,the Central China Orogen in the middle and the Himalayan Orogen in the southwest.They are keys for the formation of the Eurasian continent(Fig.1a).The Central China Orogen | Shuguang Song Liming Yang Yuqi Zhang Yaoling Niu Chao Wang Li Su Yanlin Gao | 2017 | Science Bulletin2017，62，15： | 28 |
| 2 | SHRIMP U-Pb Dating of Zircons of a Dark Eclogite and a Garnet-bearing Gneissic Granitic Rock from Bixiling,Eastern Dabie Area,Anhui Province:Isotope Chronological Evidence of Neoproterozoic UHP Metamorphism显示文摘The paper reports SHRIMP U-Pb zircon data of a dark eclogite and a post-eclogite garnet-bearing gneissic granitic rock from the Bixiling area, Yuexi County, Anhui Province, in the eastern Dabie Mountains. The eclogite, which is metamorphosed basic tuff, contains very scarce zircons in omphacite or garnet, but more zircons in quartz. They usually exhibit a double-layered texture, as shown clearly in cathodoluminescence images. Their inner main parts give a 206Pb/238U age of 757±7 Ma, representing the approximate age of the high-pressure (HP)- ultrahigh-pressure (UHP) metamorphic event during which the eclogite was formed. The outer peripheral parts of the zircons, which have been modified by late-stage fluids, give an age of 223±3 Ma. The granitic rock contains more zircons of anatectic origin found mostly in feldspar and quartz and usually also showing a similar composite texture. The inner main parts of the anatectic zircons with oscillatory zoning give a 206Pb/238U age of 727±15 Ma for the | CHENG Yuqi LIU Dunyi I.S. WILLIAMS JIAN Ping ZHUANG Yuxun GAO Tianshan | 2000 | Acta Geologica Sinica(English Edition)2000，74，4： | 13 |
| 3 | Myocardin-Related Transcription Factor A Mediates OxLDL-Induced Endothelial Injury显示文摘 | Fang, Fei Yang, Yuyu Yuan, Zhibin Gao, Yuqi Zhou, Jiliang Chen, Qi Xu, Yong | 2011 | 南京医科大学学报(自然科学版)2011，31，6： | 12 |
| 4 | Twa1/Gid8 is a β-catenin nuclear retention factor in Wnt signaling and colorectal tumorigenesis显示文摘 | Yi Lu Shanshan Xie Wen Zhang Cheng Zhang Cheng Gao Qiang Sun Yuqi Cai Zhangqi Xu Min Xiao Yanjun Xu Xiao Huang Ximei Wu Wei Liu Fudi Wang Yibin Kang Tianhua Zhou | 2017 | Cell Research2017，27，12： | 9 |
| 5 | Water quality characteristics and assessment of Yongding New River by improved comprehensive water quality identification index based on game theory显示文摘The Yongding New River is essential for the water supplies of Tianjin.To date,there is no comprehensive report that assesses the year-round water quality of the Yongding New River Main stream.Moreover,little attention has been given to determining a combined weight for improving the traditional comprehensive water quality identification index(ICWQII)by the game theory.Seven water quality parameters were investigated monthly along the main stream of the Yongding New River from May 2018 to April 2019.Organic contaminants and nitrogen pollution were mainly caused by point sources pollution,and the total phosphorus mainly by non-point source pollution.Dramatic spatio-temporal variations of water quality parameters were jointly caused by different pollutant sources and hydrometeorological factors.In terms of this study,an improved comprehensive water quality identification index(ICWQII)based on entropy weight or variation coefficient and traditional CWQII underestimated the water qualities,and an ICWQII based on the superstandard multiple method overvalued the assessments.By contrast,water qualities assessments done with an ICWQII based on the game theory matched perfectly with the practical situation.The ICWQII based on game theory proposed in this study takes into account not only the degree of disorder and variation of water quality data,but also the influence of standard-exceeded pollution indicators,whose results are relatively reasonable.All findings and the ICWQII based on game theory can provide scientific support for decisions related to the water environment management of the Yongding New River and other waters. | Yu Liu Yucheng Hu Yumei Hu Yuqi Gao Zhenying Liu | 2021 | Journal of Environmental Sciences2021，33，6： | 8 |
| 6 | Altered expression of mitochondrial related genes in the native Tibetan placents by mitochondrial cDNA array analysis显示文摘Objective: To explore the mechanism of native Tibetan fetuses adaptation to hypoxia, we tried to find the different expression genes about mitochondrial function in the native Tibetan placents. Methods: In this study, the placents of native Tibetan and the high-altitude Han (ha-Han) were collected. After the total RNA extraction, the finally synthesized cDNAs were hybridized to mitochondrial array to find the altered expression genes between them. Then, the cytochrome c oxidase 17 (Cox17), dynactin 2 (DCTN2, also known as p50), and vascular endothelial growth factor receptor (VEGFR, also known as KDR) were chosen from the altered expression genes to further verify the array results using the SYBR Green real-time PCR. Because the altered expression genes (such as Cybb and Cox17) in the array results related to the activities of COXI and COXIV, the placental mitochondria activities of COXI and COXIV were measured to find their changes in the hypoxia. Results: By a standard of ≥1.5 or ≤0.67, there were 24 different expressed genes between the native Tibetan and the ha-Han placents, including 3 up-regulated genes and 21 down-regulated genes. These genes were related to energy metabolism, signal transduction, cell proliferation, electron transport, cell adhesion, nucleotide-excision repair. The array results of Cox17, DCTN2 and KDR were further verified by the real-time RT-PCR. Through the mitochondria respiration measurements, the activity of COXI in the native Tibetan placents were higher than that of ha-Han, there was no difference in COXIV activity between them. Conclusion: The altered mitochondrial related genes in the native Tibetan placents may have a role in the high altitude adaptation for fetuses through changing the activity of mitochondrial COX. | Luo Yongjun Gao Wenxiang Zhao Xiuxin SUO Lang Chen Li Liu Fuyu Song Tonglin Chen Jian Gao Yuqi | 2009 | Journal of Medical Colleges of PLA(China)2009，24，1： | 7 |
| 7 | STING signaling activation inhibits HBV replication and attenuates the severity of liver injury and HBV-induced fibrosis显示文摘The covalently closed circular DNA(cccDNA)of HBV plays a crucial role in viral persistence and is also a risk factor for developing HBV-induced diseases,including liver fibrosis.Stimulator of interferon genes(STING),a master regulator of DNA-mediated innate immune activation,is a potential therapeutic target for viral infection and virus-related diseases.In this study,agonist-induced STING signaling activation in macrophages was revealed to inhibit cccDNA-mediated transcription and HBV replication via epigenetic modification in hepatocytes.Notably,STING activation could efficiently attenuate the severity of liver injury and fibrosis in a chronic recombinant cccDNA(rcccDNA)mouse model,which is a proven suitable research platform for HBV-induced fibrosis.Mechanistically,STING-activated autophagic flux could suppress macrophage inflammasome activation,leading to the amelioration of liver injury and HBV-induced fibrosis.Overall,the activation of STING signaling could inhibit HBV replication through epigenetic suppression of cccDNA and alleviate HBV-induced liver fibrosis through the suppression of macrophage inflammasome activation by activating autophagic flux in a chronic HBV mouse model.This study suggests that targeting the STING signaling pathway may be an important therapeutic strategy to protect against persistent HBV replication and HBV-induced fibrosis. | Yuqi Li Minjing He Ziyu Wang Zhiyun Duan Zhiwei Guo Ziteng Wang Ruijie Gong Tianhao Chu Jiabin Cai Bo Gao | 2022 | Cellular & Molecular Immunology2022，19，1： | 7 |
| 8 | Development of an automatic calibration device for high-accuracy low temperature thermometers显示文摘Based on the analysis and investigation of calibration systems for high-accuracy low temperature thermometers,a new facility for automatic calibration of high-accuracy low temperature thermometers was developed.Continuous calibration for multiple points can be made automatically with this device.According to the thermophysical characteristics of the constant-temperature block in this device,segmented Fuzzy-PID (proportional-integral-differential) algorithm was applied.The experimental results showed that the temperature fluctuation was smaller than ±0.005 K in 30 min.Therefore,this new device can fully meet the calibration requirement of high-precision low temperature thermometers. | CHEN GuangMing,GAO Xu,ZHANG ShaoZhi,CHEN Qi,TANG LiMing & LAN YuQi Institute of Refrigeration and Cryogenics,Zhejiang University,Hangzhou 310027,China | 2010 | Science China(Technological Sciences)2010，53，9： | 6 |
| 9 | Dexamethasone-loaded ROS-responsive poly(thioketal)nanoparticles suppress inflammation and oxidative stress of acute lung injury显示文摘Acute lung injury(ALI)is associated with excessive inflammatory response,leading to acute respiratory distress syndrome(ARDS)without timely treatment.A fewer effective drugs are available currently to treat the ALI/ARDS.Herein,a therapeutic nanoplatform with reactive oxygen species(ROS)-responsiveness was developed for the regulation of inflammation.Dexamethasone acetate(Dex)was encapsulated into poly(thioketal)polymers to form polymeric nanoparticles(NPs)(PTKNPs@Dex).The NPs were composed of poly(1,4-phenyleneacetonedimethylene thioketal)(PPADT)and polythioketal urethane(PTKU),in which the thioketal bonds could be cleaved by the high level of ROS at the ALI site.The PTKNPs@Dex could accumulate in the pulmonary inflammatory sites and release the encapsulated payloads rapidly,leading to the decreased ROS level,less generation of pro-inflammatory cytokines,and reduced lung injury and mortality of mice.RNA sequencing(RNA-seq)analysis showed that the therapeutic efficacy of the NPs was associated with the modulation of many immune and inflammation-linked pathways.These findings provide a newly developed nanoplatform for the efficient treatment of ALI/ARDS. | Zihe Zhai Wei Ouyang Yuejun Yao Yuqi Zhang Haolan Zhang Feng Xu Changyou Gao | 2022 | Bioactive Materials2022，7，8： | 5 |
| 10 | Finite element analysis of shape control for continuous hot rolling mills of super wide strip steel显示文摘The efficacy of shape control is the core of this technology and the main basis of automatic shape control system model designing.This passage constructs the three-dimensional elastic deformation model of CVC plus roll system in 2250 mm hot rolling mill.Comparing and analyzing different influence of working factors on control characteristic,the shape control characteristic of CVC plus roll system in its whole work time is studied,and the cause is analyzed and the difference of the roll gap curve and crown adjustable area in early and latter work time is compared.The outcome has crucial meaning in both theory and production. | YANG Guanghui LI Yuqi GAO Yang | 2013 | Computer Aided Drafting,Design and Manufacturing2013，23，1： | 5 |
| 11 | Regulation of phenylpropanoid biosynthesis by MdMYB88 and MdMYB124 contributes to pathogen and drought resistance in apple显示文摘MdMYB88 and MdMYB124 have been demonstrated to be responsible for lignin accumulation in apple under drought stress.In this study,using a metabolomic approach,we identified differentially accumulated phenylpropanoid and flavonoid metabolites in MdMYB88/124 transgenic RNAi plants under control and long-term drought stress conditions in apple roots.We confirmed the regulation of phenylalanine by MdMYB88 and MdMYB124 via UPLC-MS in apple roots under both control and drought conditions.Using Electrophoretic Mobility Shift Assay(EMSA)and ChIPquantitative PCR(qPCR)analyses,we found that MdMYB88 positively regulates the MdCM2 gene,which is responsible for phenylalanine biosynthesis,through binding to its promoter region.Under long-term drought conditions,MdMYB88/124 RNAi plants consistently accumulated increased amounts of H2O2 and MDA,while MdMYB88 and MdMYB124 overexpression plants accumulated decreased amounts of H2O2 and MDA.We also examined the accumulation of metabolites in the phenylpropanoid biosynthesis pathway in the leaves of MdMYB88 and MdMYB124 transgenic apple plants after long-term drought stress.We found that metabolites responsible for plant defense,including phenylpropanoids and flavonoids,accumulated less in the RNAi plants but more in the overexpression plants under both control and drought conditions.We further demonstrated that MdMYB88/124 RNAi plants were more sensitive to Alternaria alternata f.sp.mali and Valsa mali,two pathogens that currently severely threaten apple production.In contrast,MdMYB88 and MdMYB124 overexpression plants were more tolerant to these pathogens.The cumulative results of this study provided evidence for secondary metabolite regulation by MdMYB88 and MdMYB124,further explained the molecular roles of MdMYB88 and MdMYB124 in drought resistance,and provided information concerning molecular aspects of their roles in disease resistance. | Dali Geng Xiaoxia Shen Yinpeng Xie Yusen Yang Ruiling Bian Yuqi Gao Pengmin Li Liying Sun Hao Feng Fengwang Ma Qingmei Guan | 2020 | Horticulture Research2020，7，1： | 5 |
| 12 | Hepatocytes in a normal adult liver are derived solely from the embryonic hepatocytes显示文摘In vertebrates,body weight increases many folds as a consequence of body growth from the childhood to adulthood(e.g.,~20 folds for a mouse).Considering the fact that the liver-to-body weight ratio(LBR)stays relatively constant within species(Weglarz and Sandgren,2000;Kan et al.,2009),the cell number in a liver must therefore keep increasing along with the | Ce Gao Zhihui Zhu Yuqi Gao Li Jan Lo Jun Chen Lingfei Luo Jinrong Peng | 2018 | Journal of Genetics and Genomics2018，45，3： | 2 |
| 13 | Zebrafish hhex-null mutant develops an intrahepatic intestinal tube due to de-repression of cdx1b and pdx1显示文摘The hepatopancreatic duct (HPD) system links the liver and pancreas to the intestinal tube and is composed of the extrahepatic biliary duct, gallbladder, and pancreatic duct. Haematopoietically expressed-homeobox (Hhex) protein plays an essential role in the establishment of HPD;however, the molecular mechanism remains elusive. Here, we show that zebrafish hhex-null mutants fail to develop the HPD system characterized by lacking the biliary marker Annexin A4 and the HPD marker sox9b. The hepatobiliary duct part of the mutant HPD system is replaced by an intrahepatic intestinal tube characterized by expressing the intestinal marker fatty acid-binding protein 2a (fabp2a). Cell lineage analysis showed that this intrahepatic intestinal tube is not originated from hepatocytes or cholangiocytes. Further analysis revealed that cdx1b and pdx1 are expressed ectopically in the intrahepatic intestinal tube and knockdown of cdx1b and pdx1 could restore the expression of sox9b in the mutant. Chromatin-immunoprecipitation analysis showed that Hhex binds to the promoters of pdx1 and cdx1b genes to repress their expression. We therefore propose that Hhex, Cdx1b, Pdx1, and Sox9b form a genetic network governing the patterning and morphogenesis of the HPD and digestive tract systems in zebrafish. | Ce Gao Weidong Huang Yuqi Gao Li Jan Lo Lingfei Luo Honghui Huang Jun Chen Jinrong Peng | 2019 | Journal of Molecular Cell Biology2019，11，6： | 2 |
| 14 | Characteristics of fat metabolism in skeletal muscle of rats after hypobaric hypoxic acclimation显示文摘Objective: To investigate the characteristics of fat metabolism in rat skeletal muscle after hypobaric hypoxia acclimation. Methods: Sprague-Dawley rats were divided into 3 groups randomly: control group (H0), hypoxic 5-day group (H5), and hypoxic 15-day group (H15). Animals of H5 and 15 groups were exposed to hypobaric hypoxia chamber simulating 5 000 m high altitude for 5 d or 15 d respectively, 23 h per day. H0 group stayed outside of chamber. The level of fatty acid oxidation and uptake, and glucose oxidation were examined, and the level of non-esterified fatty acids (NEFA), ATP and phosphocreatine (PCr) were also assayed in rat skeletal muscles. Results: The contents of ATP and PCr in H5 group were lower than those in H0 and H15 groups (P<0.05), while there was no significant difference between H0 and H15. Compared with H0, the blood NEFA level in all hypoxia groups was increased significantly (P<0.05). The muscle NEFA level in H15 group was greatly higher than that in H0 and H5 groups. The rates of fatty acid oxidation and uptake in H15 group were significantly higher than those in H0 and H5 groups (P<0.05), and the rate of glucose oxidation in all hypoxia groups was significantly decreased than that in H0 group (P<0.05). Conclusion: It is concluded that the enhanced fat oxidation may be one of the mechanisms in the maintenance of energy homeostasis after hypobaric hypoxic acclimation. | Mao Sunzhong Gao Yuqi Chen Jian Liu Fuyi Gao Wenxiang Huang Jian Liao Weigong Cai Mingchun | 2008 | Journal of Medical Colleges of PLA(China)2008，23，5： | 2 |
| 15 | Carbon-Based Electrode Materials for Supercapacitor: Progress, Challenges and Prospective Solutions显示文摘 | Xian Jian Shiyu Liu Yuqi Gao Wei Tian Zhicheng Jiang Xiangyun Xiao Hui Tang Liangjun Yin | 2016 | Journal of Electrical Engineering2016，4，2： | 2 |
| 16 | Electrostatically selbassembled multilayer film formed by a novel ruthenium( Ⅱ ) complex and 13 显示文摘 | Zhang Yuqi Wang Kezhi Gao Lihua | 2005 | Colloids and Surfaces A2005，257，： | 1 |
| 17 | Advances in studies of the tribological behavior of molecular deposition films显示文摘An overview of the advances in studies on tribology of molecular deposition(MD)films is presented here to summarize the studies of nanofrictional properties,adhesion,wear and mechanical behavior,as well as the molecular dynamics simulation of nanotribological properties of the film in the last decade.Some key research topics which need to be investigate further are addressed. | Xiao Yuqi Zhang Siwei Wang Deguo Gao Manglai | 2008 | Petroleum Science2008，5，4： | 1 |
| 18 | Electrostatically self-assembled muhilayer film formed by a novel ruthenium (II) complex and 显示文摘 | Zhang Yuqi Wang Kezhi Gao Lihua | 2005 | Colloids and Sur- faces A: Physicochemical Engineering Aspects2005，，5： | 1 |
| 19 | SIRT7 orchestrates melanoma progression by simultaneously promoting cell survival and immune evasion via UPR activation显示文摘Melanoma is the most lethal type of skin cancer,originating from the malignant transformation of melanocyte.While the development of targeted therapy and immunotherapy has gained revolutionary advances in potentiating the therapeutic effect,the prognosis of patients with melanoma is still suboptimal.During tumor progression,melanoma frequently encounters stress from both endogenous and exogenous sources in tumor microenvironment.SIRT7 is a nuclear-localized deacetylase of which the activity is highly dependent on intracellular nicotinamide adenine dinucleotide(NAD+),with versatile biological functions in maintaining cell homeostasis.Nevertheless,whether SIRT7 regulates tumor cell biology and tumor immunology in melanoma under stressful tumor microenvironment remains elusive.Herein,we reported that SIRT7 orchestrates melanoma progression by simultaneously promoting tumor cell survival and immune evasion via the activation of unfolded protein response.We first identified that SIRT7 expression was the most significantly increased one in sirtuins family upon stress.Then,we proved that the deficiency of SIRT7 potentiated tumor cell death under stress in vitro and suppressed melanoma growth in vivo.Mechanistically,SIRT7 selectively activated the IRE1α-XBP1 axis to potentiate the pro-survival ERK signal pathway and the secretion of tumorpromoting cytokines.SIRT7 directly de-acetylated SMAD4 to antagonize the TGF-β-SMAD4 signal,which relieved the transcriptional repression on IRE1αand induced the activation of the IRE1α-XBP1 axis.Moreover,SIRT7 up-regulation eradicated anti-tumor immunity by promoting PD-L1 expression via the IRE1α-XBP1 axis.Additionally,the synergized therapeutic effect of SIRT7 suppression and anti-PD-1 immune checkpoint blockade was also investigated.Taken together,SIRT7 can be employed as a promising target to restrain tumor growth and increase the effect of melanoma immunotherapy. | Xiuli Yi Huina Wang Yuqi Yang Hao Wang Hengxiang Zhang Sen Guo Jianru Chen Juan Du Yangzi Tian Jingjing Ma Baolu Zhang Lili Wu Qiong Shi Tianwen Gao Weinan Guo Chunying | 2023 | Signal Transduction and Targeted Therapy2023，8，4： | 1 |
| 20 | Ample dietary fat reduced the risk of primary vesical calculi by inducing macrophages to engulf budding crystals in mice显示文摘Although primary vesical calculi is an ancient disease,the mechanism of calculi formation remains unclear.In this study,we established a novel primary vesical calculi model with D,L-choline tartrate in mice.Compared with commonly used melamine and ethylene glycol models,our model was the only approach that induced vesical calculi without causing kidney injury.Previous studies suggest that proteins in the daily diet are the main contributors to the prevention of vesical calculi,yet the effect of fat is overlooked.To assay the relationship of dietary fat with the formation of primary vesical calculi,D,L-choline tartrate-treated mice were fed a high-fat,low-fat,or normal-fat diet.Genetic changes in the mouse bladder were detected with transcriptome analysis.A high-fat diet remarkably reduced the morbidity of primary vesical calculi.Higher fatty acid levels in serum and urine were observed in the high-fat diet group,and more intact epithelia in bladder were observed in the same group compared with the normal-and low-fat diet groups,suggesting the protective effect of fatty acids on bladder epithelia to maintain its normal histological structure.Transcriptome analysis revealed that the macrophage differentiation-related gene C-X-C motif chemokine ligand 14(Cxcl14)was upregulated in the bladders of high-fat diet-fed mice compared with those of normal-or low-fat diet-fed mice,which was consistent with histological observations.The expression of CXCL14 significantly increased in the bladder in the high-fat diet group.CXCL14 enhanced the recruitment of macrophages to the crystal nucleus and induced the transformation of M2 macrophages,which led to phagocytosis of budding crystals and prevented accumulation of calculi.In human bladder epithelia(HCV-29)cells,high fatty acid supplementation significantly increased the expression of CXCL14.Dietary fat is essential for the maintenance of physiological functions of the bladder and for the prevention of primary vesical calculi,which provides new ideas for the reduction of morbidity of primary vesical calculi. | Huiling Chen Kaiqiang Hu Yaru Liang Yuqi Gao Chenye Zeng Kang Xu Xiaojin Shi Liyuan Li Yuemiao Yin Yi Qiao Ying Qiu Qingfei Liu Zhao Wang | 2022 | Acta Pharmaceutica Sinica B2022，12，2： | 1 |
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