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| 1 | Ribosome biogenesis gene DEF/UTP25 is essential for liver homeostasis and regeneration显示文摘Hepatocytes are responsible for diverse metabolic activities in a liver. Proper ribosome biogenesis is essential to sustain the function of hepatocytes. There are approximately 200 factors involved in ribosome biogenesis;however, few studies have focused on the role of these factors in maintaining liver homeostasis. The digestive organ expansion factor(def) gene encodes a nucleolar protein Def that participates in ribosome biogenesis. In addition, Def forms a complex with cysteine protease Calpain3(Capn3) and recruits Capn3 to the nucleolus to cleave protein targets. However, the function of Def has not been characterized in the mammalian digestive organs. In this report, we show that conditional knockout of the mouse def gene in hepatocytes causes cell morphology abnormality and constant infiltration of inflammatory cells in the liver. As age increases, the def conditional knockout liver displays multiple tissue damage foci and biliary hyperplasia. Moreover, partial hepatectomy leads to sudden acute death to the def conditional knockout mice and this phenotype is rescued by intragastric injection of the anti-inflammation drug dexamethasone one day before hepatectomy. Our results demonstrate that Def is essential for maintaining the liver homeostasis and liver regeneration capacity in mammals. | Weidong Huang Feng Chen Quanxin Ma Jiaojiao Xin Jiaqi Li Jun Chen Bin Zhou Minli Chen Jun Li Jinrong Peng | 2020 | Science China(Life Sciences)2020，63，11： | 1 |
| 2 | A glimpse of endocrine pancreas development from single-cell analyses显示文摘Diabetes is a global public health concern in the 21st century. According to the report in the International Diabetes Federation Diabetes Atlas in 2015, 415 million adults suffer from diabetes globally. Although considerable progress has made in the treatment of diabetes, such as insulin administration, researchers are still looking for alternative therapeutic approaches, e.g. islet transplantation from cadaveric donors, for its radical cure. However, this approach is limited due to the scarcity of donors and availability of islet cells. | Ce Gao Jinrong Peng | 2019 | Journal of Molecular Cell Biology2019，11，6： | 0 |
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