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| 1 | Glutamine transporters as pharmacological targets: From function to drug design显示文摘Among the different targets of administered drugs,there are membrane transporters that play also a role in drug delivery and disposition.Moreover,drug-transporter interactions are responsible for off-target effects of drugs underlying their toxicity.The improvement of the drug design process is subjected to the identification of those membrane transporters mostly relevant for drug absorption,delivery and side effect production.A peculiar group of proteins with great relevance to pharmacology is constituted by the membrane transporters responsible for managing glutamine traffic in different body districts.The interest around glutamine metabolism lies in its physio-pathological role;glutamine is considered a conditionally essential amino acid because highly proliferative cells have an increased request of glutamine that cannot be satisfied only by endogenous synthesis.Then,glutamine transporters provide cells with this special nutrient.Among the glutamine transporters,SLC1A5,SLC6A14,SLC6A19,SLC7A5,SLC7A8 and some members of SLC38 family are the best characterized,so far,in both physiological and pathological conditions.Few 3D structures have been solved by CryoEM;other structural data on these transporters have been obtained by computational analysis.Interactions with drugs have been described for several transporters of this group.For some of them,the studies are at an advanced stage,for others,the studies are still in nuce and novel biochemical findings open intriguing perspectives. | Mariafrancesca Scalise Lorena Pochini Michele Galluccio Lara Console Cesare Indiveri | 2020 | Asian Journal of Pharmaceutical Sciences2020，15，2： | 5 |
| 2 | Modeling signal propagation in nano-machine-to-neuron communications显示文摘 | GALLUCCIO L PALAZZO S | 2011 | Nano Communication Networks2011，2，4： | 1 |
| 3 | Insulin resistance and vitaminB12therapy in patients with metabolic syndrome:relationship be-tween homocysteine levels and hyperinsulinemia显示文摘 | Setola E Monti LD Galluccio E | 2004 | Eur J En-docrinol2004，15，11： | 1 |
| 4 | Scaling in currency exchange显示文摘 | Galluccio S Caldarelli G Marsili M | 1997 | Physica A1997，，245： | 1 |
| 5 | Tracheobronchial amy- loidosis treated by endobronchial laser resection and self expanding Y stem 显示文摘 | Fiorelli A Accardo M Galluccio G | 2013 | Arch Bronconeumol2013，49，7： | 1 |
| 6 | OCTN cation transport- ers in health and disease: role as drug targets and assay develop- ment显示文摘 | Pochini L Scalise M Galluccio M | 2013 | JBiomolScreen2013，18，8： | 1 |
| 7 | Interven- tional endoscopy in the management of benign tracheal stenosis :definitive treatment at long-term follow-up 显示文摘 | Galluccio G Lucantoni G Battistoni P | 2009 | Eur J Cardiothorac Surg2009，35，3： | 1 |
| 8 | Modeling and de- signing efficient data aggregation in wireless sensor networks under en- tropy and energy bounds显示文摘 | GALLUCCIO L PALAZZO S CAMPBELL A T | 2009 | International Journal of Wireless In- formation Networks2009，16，3： | 1 |
| 9 | A MAC/routing cross-layer approach to geographic forwarding in wireless sensor networks 显示文摘 | Galluccio L Leonardi A Morabito G | 2007 | Ad Hoc Networks2007，5，6： | 1 |
| 10 | Hyperinsulinemia and impaired leptin adiponectin ratio associate with endothelial nitric oxide synthase polymorphism in subjects with in-stent restenosis显示文摘 | Galluccio E Piatti P Citterio L | | 0，，05： | 1 |
| 11 | Graph based k-means clustering显示文摘 | GALLUCCIO L MICHEL O COMON P | 2012 | Signal Processing2012，92，9： | 1 |
| 12 | Interventional endoscopy in the management of be- nign tracheal stenoses: definitive treatment at long-term follow-up 显示文摘 | GALLUCCIO G LUCANTONI G BATI'ISTONI P | 2009 | Eur J Cardiothorac Surg2009，35，3： | 1 |
| 13 | Insulin resistaneta ce and endothelial function are improved after folate and vitamin B12 therapy in patients with metabolic syndrome: rela tionship between homocysteine levels and hyperinsu-linemia 显示文摘 | Setola E Monti L D Galluccio E | 2004 | Eur J Endocrinol2004，151，4： | 1 |
| 14 | Clustering with a New Distance Measure Based on a Dual-Rooted Tree 显示文摘 | GALLUCCIO L MICHEL O COMON P | 2013 | Information Sciences2013，251，： | 1 |
| 15 | Scaling in currency exchange显示文摘 | GALLUCCIO S CALDARELLI G MARSILI M | 1997 | Physiea A1997，245，3： | 1 |
| 16 | Interventional endoscopy in the management of benign tracheal stenoses: definitive treatment at long-term follow-up 显示文摘 | Galluccio G Lucantoni G Battistoni P | 2009 | Eur J Cardiothorac Surg2009，35，： | 1 |
| 17 | Interventional endoscopy in the management of benign tracheal stenoses:definitive treatment at long-term follow-up显示文摘 | Galluccio G Lucantoni G Battistoni P | | 0，，： | 1 |
| 18 | Spontaneous group management in mobile ad hoc networks显示文摘 | GALLUCCIO L MORABITO G PALAZZO S | 2004 | ACM Wireless Network2004，10，4： | 1 |
| 19 | Membranetransporters for the special amino acid glutamine: structure/function relationships and relevance to human health显示文摘 | Pochini L Scalise M Galluccio M Indiveri C | 2014 | FrontChem2014，2，： | 1 |
| 20 | lnterventional endoscopy in the management of benign tracheal stenoscs: definitive treatment at long-term follow-up 显示文摘 | Galluccio G Lucantoni G Battistoni P | 2009 | Eur J Cardiothorac Surg2009，35，3： | 1 |
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