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| 1 | BCLC策略:预后预测和治疗推荐2022版更新显示文摘2018版BCLC预后和治疗推荐策略发布后,肝细胞癌(简称HCC)的研究又取得了重大进展。本次更新基于肝癌各领域的研究进展结果。重点关注影响策略的重要研究进展。虽然近年的研究结果成绩斐然,但将其引入为临床医生和研究者提供行动依据的循证模型指南来说证据效力依然不够确切。本文对该问题进行分析,阐述了为HCC患者制定个体化治疗临床决策所需的批判性思维和专业知识。 | Reig M Forner A Rimola J Ferrer-Fabrega J Burrel M Garcia-Criado A Kelley RK Galle PR Mazzaferro V Salem R Sangro B Singal AG Vogel A Fuster J Ayuso C Bruix J 刘永凡(摘译) 崔笑(摘译) 耿小平(审校) | 2022 | 肝胆外科杂志2022，30，5： | 80 |
| 2 | Coexpression of receptor-tyrosine-kinases in gastric adenocarcinoma-a rationale for a molecular targeting strategy?显示文摘AIM: To define the (co-)expression pattern of target receptor-tyrosine-kinases (RTK) in human gastric adenocarcinoma. METHODS: The (co-)expression pattern of VEGFR1-3,PDGFRα/b and EGFR1 was analyzed by RT-PCR in 51 human gastric adenocarcinomas. In addition,IHC staining was applied for confirmation of expression and analysis of RTK localisation. RESULTS: The majority of samples revealed a VEGFR1 (98%),VEGFR2 (80%),VEGFR3 (67%),PDGFRα (82%) and PDGFRβ(82%) expression,whereas only 62% exhibited an EGFR1 expression. 78% of cancers expressed at least four out of six RTKs. While VEGFR1-3 and PDGFRα revealed a predominantly cytoplasmatic staining in tumor cells,accompanied by an additional nuclear staining for VEGFR3 ,EGFR1 was almost exclusively detected on the membrane of tumor cells. PDGFRβ was restricted to stromal pericytes,which also depicted a PDGFRα expression.receptor-tyrosine-kinases coexpression in gastric adenocarcinoma and might therefore encourage an application of multiple-target RTK-inhibitors within a combination therapy. | Daniel Drescher Markus Moehler Ines Gockel Kirsten Frerichs Annett Müller Friedrich Dünschede Thomas Borschitz Stefan Biesterfeld Martin Holtmann Thomas Wehler Andreas Teufel Kerstin Herzer Thomas Fischer Martin R Berger Theodor Junginger Peter R Galle Carl C Schimanski | 2007 | World Journal of Gastroenterology2007，13，26： | 4 |
| 3 | Real-Time Three-Dimensional Echocardiography: A Novel Technique to Quantify Global Left Ventricular Mechanical Dyssynchrony显示文摘 | S Kapetanakis M T. Kearney A Siva N Gall M Cooklin M J. Monaghan | 2005 | Circulation2005，，7： | 3 |
| 4 | Real-Time Three-Dimensional Echocardiography: A Novel Technique to Quantify Global Left Ventricular Mechanical Dyssynchrony显示文摘 | S Kapetanakis M T. Kearney A Siva N Gall M Cooklin M J. Monaghan | 2005 | Circulation2005，，： | 2 |
| 5 | Microstructure-based Fatigue Modeling of Cast A356- T6 Alloy显示文摘 | D L McDowell K Gall M F Horstemeyer | 2003 | Engineering Fracture Mechanics2003，70，1： | 1 |
| 6 | Increase expression of matrix metalloproteinases and matrix degrading activity invulnerable regions of human atherosclerotic plaques显示文摘 | GALLS Z S SUKHOVA G K LARK M W | 1994 | J Clin Invest1994，94，： | 1 |
| 7 | The auxili-like phosphoprotein Swa2p is required for clathrin function in yeast显示文摘 | GALL W E HIGGINBOTHAM M A CHEN C Y | 2000 | Curr Biol2000，10，： | 1 |
| 8 | New chemotherapeutic strategies in eolorectal caneer显示文摘 | Moehler M Teufel A Galle PR | 2005 | Recent Results Cancer Res2005，165，： | 1 |
| 9 | Loss of sugar detec-tion by GLUT2 affects glucose homeostasis in mice显示文摘 | Stolarczyk E Le Gall M Even P | 2007 | PLoS ONE2007，2，12： | 1 |
| 10 | Water balance in a banded vegeta- tion pattern : A case study of tiger bush in western Niger显示文摘 | Galle S Ehrmann M Peugeot C | 1999 | Catena1999，37，12： | 1 |
| 11 | Atomistic simulations on the tensile debonding of an aluminum-silicon interface显示文摘 | Gall K Horstemeyer M F Schilfgaarde M V Baskes M I | 2000 | J Mech Phys Solids2000，48，： | 1 |
| 12 | Thermal N2O deconposition in regenerative heat exchanger reactors显示文摘 | Galle M Agar D W Watzenberger O | 2001 | Chemical Engineering Science2001，56，2001： | 1 |
| 13 | Thermal processing of polycrystalline Ni-Ti shape memory alloys 显示文摘 | FRICK C P ORTEGA A M TYBER J MAKSOUND A E M MAIER H J LIU Y N GALL K | 2005 | Materials Science and Engineering A2005，405，12： | 1 |
| 14 | Formation and detection of RNA-DNA hybrid molecules in cytological preparations显示文摘 | Gall J G Pardu- M L | 1969 | Proc Natl Acad Sci U S A1969，63，2： | 1 |
| 15 | Chemokine macrophage inflammatory protein-lalpha mRNA expression in lung biopsy specimens of primary pulmonary hypertension显示文摘 | Fartoukh M Emilie D Le Gall C | 1998 | Chest1998，114，： | 1 |
| 16 | Characterization and potential clinical applications of autoantibodies against cytokines显示文摘 | de-Lemos-Rieper C Galle P Hansen M B | | 0，，01： | 1 |
| 17 | Guest editorst introduction: as- pect-oriented programming 显示文摘 | Gall M Christa S | 2006 | IEEE Software2006，23，1： | 1 |
| 18 | Quantification of total emission of air pollutants from Beijing using mobile mini-DOAS 显示文摘 | Johansson M Galle B Yu Tong | 2008 | Atmospheric Environment2008，42，： | 1 |
| 19 | The influence of modified intermetallics and Si particles on fatigue crack paths in a cast A356 Al alloy显示文摘 | Gall K Yang N Horstemeyer M | 1999 | Fatigue Fract Eng Mater Struct1999，26，6： | 1 |
| 20 | Molecular-imprinted、polymer-coated quartz crystal microbalances for the detection of terpenes显示文摘 | Percival C J Stanley S Galle M | 2001 | Anal Chem2001，73，： | 1 |
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