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| 1 | Insulin-mimetic compound hexaquis(benzylammonium) decavanadate is antilipolytic in human fat cells显示文摘AIM To assess in rodent and human adipocytes the antilipolytic capacity of hexaquis(benzylammonium) decavanadate(B6V10), previously shown to exert antidiabetic effects in rodent models, such as lowering free fatty acids(FFA) and glucose circulating levels.METHODS Adipose tissue(AT) samples were obtained after informed consent from overweight women undergoing plastic surgery. Comparison of the effects of B6V10 and reference antilipolytic agents(insulin,benzylamine,vanadate) on the lipolytic activity was performed on adipocytes freshly isolated from rat, mouse and human AT. Glycerol release was measured using colorimetric assay as an index of lipolytic activity. The influence of B6V10 and reference agents on glucose transport into human fat cells was determined using the radiolabelled 2-deoxyglucose uptake assay.RESULTS In all the species studied, B6V10 exhibited a dosedependent inhibition of adipocyte lipolysis when triglyceride breakdown was moderately enhanced by β-adrenergic receptor stimulation. B6V10 exerted on human adipocyte a maximal lipolysis inhibition of glycerol release that was stronger than that elicited by insulin. However, B6V10 did not inhibit basal and maximally stimulated lipolysis. When incubated at dose ≥ 10 μmol/L, B6V10 stimulated by twofold the glucose uptake in human fat cells, but-similarly to benzylamine-without reaching the maximal effect of insulin, while it reproduced one-half of the insulin-stimulation of lipogenesis in mouse fat cells. CONCLUSION B6V10 exerts insulin-like actions in adipocytes, including lipolysis inhibition and glucose transport activation. B6V10 may be useful in limiting lipotoxicity related to obesity and insulin resistance. | Christian Carpéné Silvia Garcia-Vicente Marta Serrano Luc Marti ChloéBelles Miriam Royo Jean Galitzky Antonio Zorzano Xavier Testar | 2017 | World Journal of Diabetes2017，8，4： | 2 |
| 2 | Increased lipolysis in adi- pose tissue and lipid mobilizationg to natriuretic peptides during low - calorie diet in obese women显示文摘 | Sengenes C Stich V Berlan M Hejnova J Lafontan M Pariskova Z galitzky J | 2002 | Int J Obes Relat Metab Disord2002，26，： | 1 |
| 3 | Clozapine improves dyskinesias in Parkinson disease: a double blind, placebo-controlled study 显示文摘 | Durif F Debilly B Galitzky M | 2004 | Neurology2004，62，： | 1 |
| 4 | Adipose tissue endothelialcells from obese human subjects:differences among depots inangiogenic,metabolic,and inflammatory gene expression and cellularsenescence显示文摘 | Villaret A Galitzky J Decaunes P | 2010 | Diabetes2010，59，11： | 1 |
| 5 | Effects of hypoxia on the expression of proangiogenic factors in differentiated 3T3-F442A adipocytes显示文摘 | Lolmede K Durand de Saint Front V Galitzky J | 2003 | Int J Obes Relat Metab Disord2003，27，： | 1 |
| 6 | Effects of hypoxia on the expression of proangiongenic factors in differentiated 3T3-F442A adipocytes显示文摘 | Lolmède K Durand de Saint Front V Galitzky J | 2003 | Int J Obes Relat Metab Disord2003，27，10： | 1 |
| 7 | Clozapine improves dyskinesias in Parkinson disease: a double - blind, placebo - con- trolled study 显示文摘 | Durif F Debilly B Galitzky M | 2004 | Neurology2004，62，3： | 1 |
| 8 | Expression of beta3-adrenoceptors with low lipolytic action in human subcutaneous white adipocytes显示文摘 | TAVERNIER G BARBE P GALITZKY J | 1996 | J Lipid Res1996，37，1： | 1 |
| 9 | Effects of hypoxia on the expression of proangiogenic factors in differentiated 3T3-F442A adipocytes 显示文摘 | Lolmede K Durand de Saint Front V Galitzky J | 2003 | Int J Obes Relat Metab Disord2003，27，10： | 1 |
| 10 | Unexpected trafficking of immune cells within the adipose tissue during the onset of obesity显示文摘 | Duffaut C Galitzky J Lafontan M | 2009 | Biochem Biophys Res Commun2009，384，： | 1 |
| 11 | Atrial natriuretic peptide inhibits the production of adipokines and cytokines linked to inflammation and insulin resistance in human subcutaneous adipose tissue显示文摘 | C. Moro E. Klimcakova K. Lolmède M. Berlan M. Lafontan V. Stich A. Bouloumié J. Galitzky P. Arner D. Langin | 2007 | Diabetologia2007，，5： | 1 |
| 12 | Specific stimulation of adipose tissue adrenergic beta 3 receptors by octopamine 显示文摘 | Galitzky J | 1993 | C R Acad Sci1993，316，5： | 1 |
| 13 | 显示文摘 | Pblat M Verwaerade P Galitzky J | 2003 | J Pharmacol Exp Ther2003，304，1： | 1 |
| 14 | Sleep disruption,daytime somnolence and'sleep attacks'in Parkinson's disease:a clinical survey in PD patients and age‐matched healthy volunteers显示文摘 | Ferreira J J Desboeuf K Galitzky M | 2006 | European Journal of Neurology2006，13，3： | 1 |
| 15 | Selective activation of beta3-adrenoceptors by oetopamine:comparative studies in mammalian fat cell显示文摘 | Carpene C Galitzky J Fontana E | 1999 | Naunyn Schmiedebergs Arch Pharmacol1999，359，4： | 1 |
| 16 | In situ assessment of the role of the β1, β2,β3-adrenoceptors in the control of lipolysis and nutritive blood flow in human subcutaneous adipose tissue显示文摘 | Barbe P Millet L Galitzky J | 1996 | Br J Pharmacol1996，117，5： | 1 |
| 17 | Natriuretic peptides:a newlipolytic pathway in human fat cells显示文摘 | Sengenes C Moro C Galitzky J | | 0，，： | 1 |
| 18 | High isoproterenol doses are required to activate beta3-adrenoceptor-mediated functions in dogs显示文摘 | Pelat M Verwaerde P Galitzky J | 2003 | J Pharmacol Exp Ther2003，304，1： | 1 |
| 19 | Selective activation of beta3-adrenoceptors by octopamine: Comparative studies in mammalian fat cells 显示文摘 | CARPENEC GALITZKY J FONTANA E | 1999 | Naunyn Schmiedebergs Arch Pharmacol1999，359，4： | 1 |
| 20 | High isop roterenoldoses are required to activate β3-adrenocep tormediated function in dogs 显示文摘 | Pelat M Verwaerde P Galitzky J | 2003 | J Pharmacol Exp Ther2003，304，： | 1 |
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