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| 1 | Innate immune signaling and regulation in cancer immunotherapy显示文摘先存在的 T 煽动房间的肿瘤微型环境有预示的用途并且能也为对当代的癌症免疫疗法的反应预兆。对联系肿瘤的抗原的自发的 T 房间回答的产生取决于天生的有免疫力的激活,运动打它我干扰素(IFN ) 生产。最近的工作为在这个过程察觉到的 cytosolic DNA 的 STING 小径揭示了一个主要角色。事件的这串联贡献 Batf3 系树枝状的房间(DC ) 的激活,它看起来对反肿瘤免疫中央。Non-T 煽动房间的肿瘤为 Batf3 DC 招募缺乏 chemokines,有很少 Batf3 DC,并且缺乏一种类型我 IFN 基因签名,建议那没有通过天生的有免疫力的激活可以是因缺乏自发的 T 房间激活和累积的最终的原因。与手里的这个信息,为触发天生的有免疫力的激活和 Batf3 DC 招募的新策略正在被开发,包括为 de novo 免疫者 priming 的新奇圈套收缩筋。最终,有效天生的有免疫力的使活跃之物的成功的发展应该扩展能对免疫疗法作出回应的病人的部分,例如与检查点封锁抗体。 | Leticia Corrales Vyara Matson Blake Flood Stefani Spranger Thomas F Gajewski | 2017 | Cell Research2017，27，1： | 13 |
| 2 | MYC -- a thorn in the side of cancer immunity显示文摘 | Stefani Spranger Thomas F Gajewski Justin Kline | 2016 | Cell Research2016，26，6： | 2 |
| 3 | Immunization lf HLA-A2+ melanoma patients with MAGE-3 or Melan A peptide-pulsed autologous peripheral blood mononuclear cells plus recombinant human interleukin 12显示文摘 | Gajewski TF Fallarino F Ashikari A | 2001 | Clin Caner Tes2001，7，3： | 1 |
| 4 | The STING pathway and the T cell-inflamed tumor microenvironment 显示文摘 | WOO S R CORRALES L GAJEWSKI T F | 2015 | Trends in Immunology2015，36，4： | 1 |
| 5 | hnmune suppression in the tumor microenvironment 显示文摘 | Gajewski T F Meng Y Harlin H | 2006 | J Immunother2006，29，3： | 1 |
| 6 | Failure at the effector phase: immune barriers at the level of the melanoma tumor microenvironment显示文摘 | GAJEWSKI T F | 2007 | Clin Cancer Res2007，13，18： | 1 |
| 7 | Immunization of HLA-A2+ melanoma patients with MAGE-3 or MelanA peptide-pulsed autologous peripheral blood mononuclear cells plus recombinant human interleukin 12 显示文摘 | Fallarino F Ashikari A | 2001 | Clin Cancer Res2001，7，3： | 1 |
| 8 | The apical-basal cellpolarity determinant Crumbs regulates Hippo signaling in Drosophi-la显示文摘 | Chen CL Gajewski KM Hamaratoglu F | 2010 | Proc National Acad Sci2010，107，15： | 1 |
| 9 | Concentration of bovine pregnancy associated glycoprotein in plasma and milk: its application for pregnancy diagnosis in cows 显示文摘 | Gajewski Z Melo De Sousa N Beckers J F | 2008 | J Physiol Pharmacol2008，59，9： | 1 |
| 10 | Failure at the Effector Phase:ImmuneBarriers at the Level of the Melanoma Tumor Microenvimnment显示文摘 | Thomas F Gajewski | 2007 | Clin Cancer Res2007，13，18： | 1 |
| 11 | Concentration of bovine pregnancy associated glycoprotein in plasma and milk: its application for pregnancy diagnosis in cows 显示文摘 | Gajewski Z Melo de Sousa N Beckers J F | 2008 | J Physiol Pharmacol2008，59，9： | 1 |
| 12 | Gene signature in melanoma associated with clinical activity: a potential clue to unlock cancer immunotherapy显示文摘 | Gajewski T F Louahed J Brichard V G | 2010 | Cancer J2010，16，4： | 1 |
| 13 | An adenoviral vector encoding dominant negative Cbl lowers the threshold for T cell activation in postthymie T cells显示文摘 | Zha Y Gajewski T F | 2007 | Cell Immunol2007，247，2： | 1 |
| 14 | Immumization of HLAA2 + melanoma patients with MAGE-3 or Melan A peptide-pulsed autologous perioheral blood mononuclear cells plus recombinant human interleukin 12显示文摘 | Gajewski T F Fallarino F Ashikari A | 2001 | Clin Cancer Res2001，7，13： | 1 |
| 15 | Clinical development of mAbs to block the PD1 pathway as an immunotherapy for cancer显示文摘 | Kline J Gajewski T F | 2010 | Curr Opin In- vestig Drugs2010，11，12： | 1 |
| 16 | Failure at the effector phase : immue barriers at the level of the melanoma tumor microenvironment 显示文摘 | Gajewski T F | 2007 | Clin Cancer Res2007，13，181： | 1 |
| 17 | Immune sup- pression in the tumor microenvironment显示文摘 | Gajewski T F Meng Y Harlin H | 2006 | J Immu- nother2006，29，3： | 1 |
| 18 | hnmune suppression in the tumor microenvironment 显示文摘 | Gajewski T F Meng Y Harlin H | 2006 | J Immunother2006，29，3： | 1 |
| 19 | Immunization o HLA-A2 + melanoma patients with MAGE-3 or MelanA peptide-pulsed autologous peripheral blood mononuclear cells plus recombinant human interleukin 12显示文摘 | Gajewski TF Fallarino F Ashikari A | 2001 | Clin Cance Res2001，7，89： | 1 |
| 20 | Phase II trial of the O^6-alkylguanine DNA alkyhransferase inhibitor O ^6-benzylguanme and 1, 3-bis (2-chloroethyl)-1-nitrosourea in advanced melanoma 显示文摘 | GAJEWSKI T F SOSMAN J GERSON S L | 2005 | Clin Cancer Res2005，11，21： | 1 |
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