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| 1 | Superchiral near fields detect virus structure显示文摘Optical spectroscopy can be used to quickly characterise the structural properties of individual molecules.However,it cannot be applied to biological assemblies because light is generally blind to the spatial distribution of the component molecules.This insensitivity arises from the mismatch in length scales between the assemblies(a few tens of nm)and the wavelength of light required to excite chromophores(≥150 nm).Consequently,with conventional spectroscopy,ordered assemblies,such as the icosahedral capsids of viruses,appear to be indistinguishable isotropic spherical objects.This limits potential routes to rapid high-throughput portable detection appropriate for point-of-care diagnostics.Here,we demonstrate that chiral electromagnetic(EM)near fields,which have both enhanced chiral asymmetry(referred to as superchirality)and subwavelength spatial localisation(∼10 nm),can detect the icosahedral structure of virus capsids.Thus,they can detect both the presence and relative orientation of a bound virus capsid.To illustrate the potential uses of the exquisite structural sensitivity of subwavelength superchiral fields,we have used them to successfully detect virus particles in the complex milieu of blood serum. | Tarun Kakkar Chantal Keijzer Marion Rodier Tatyana Bukharova Michael Taliansky Andrew J.Love Joel J.Milner Affar S.Karimullah Laurence D.Barron Nikolaj Gadegaard Adrian J.Lapthorn Malcolm Kadodwala | 2020 | Light(Science & Applications)2020，9，1： | 2 |
| 2 | The control of human mesen- chymal cell differentiation using nanoscale symmetry and disorder 显示文摘 | Dalby M J Gadegaard N Tare R | 2007 | Nat Mater2007，6，12： | 1 |
| 3 | Atomic force microscopy in biology: technology and techniques显示文摘 | Gadegaard N | 2006 | Biotech Histochem2006，81，23： | 1 |
| 4 | Interactions with nanoscale topography: adhesion quantification and signal transduc- tion in cells of osteogenic and multipotent lineage 显示文摘 | Biggs M J Riehards RG Gadegaard N | 2009 | J Biomed Mater Res A2009，91，1： | 1 |
| 5 | Thrombolytie therapy after intraventrieular haemorrhage 显示文摘 | Gadegaard KH Dahl BL Hansen TS | 2010 | Ugeskrift for laeger2010，172，： | 1 |
| 6 | The use of nanoscale topography to modulate the dynamics of adhesion formation in prima- ry osteoblasts and ERK/MAPK signalling in ST RO-1 + enriched skeletal stem eells显示文摘 | Biggs M J Richards RG Gadegaard N | 2009 | Biomaterials2009，30，28： | 1 |
| 7 | The effects of nanoscale pits on primary human osteoblast adhesion formation and cellular spreading 显示文摘 | Biggs MJ Richards RG Gadegaard N | 2007 | J Mater Sci Mater Med2007，18，2： | 1 |
| 8 | Nanopatterned UV cur- able hydrogels for biomedical applieations显示文摘 | Gaston A Khokhar A Z Bilbao L S ez-Mart nez V Cortes A Obieta I Gadegaard N | 2010 | Microelec- tronic Engineering2010，87，58： | 1 |
| 9 | Cells react to nanoscale order and symmetry in their surroundings 显示文摘 | Curtis ASG Gadegaard N Dalby MJ | 2004 | IEEE Trans Nanobioscience2004，3，1： | 1 |
| 10 | Cells react to nanoscale order and symmetry in their surroundings显示文摘 | Curtis AS Gadegaard N Dalby MJ | 2004 | IEEE Trans Nanobioscience2004，3，1： | 1 |
| 11 | The Control of Human Mesenchymal Cell Differentiation Using Nanoscale Symmetry and Disorder显示文摘 | Dalby M J Gadegaard N Tare R | 2009 | Nature Materials2009，6，12： | 1 |
| 12 | (:ells react to nanoscale order and symmetry in their surroundings显示文摘 | Curds AS Gadegaard N Dalby MJ | 2004 | IIgEE Trans Nanobiosci2004，3，1： | 1 |
| 13 | The control of human mesenchymal cell differentiation using nanoscale symmetry and disorder显示文摘 | Dalby M J Gadegaard N Tare R | 2007 | Nat Mater2007，6，12： | 1 |
| 14 | The control of human mesenchymal cell differentiation using nanoscale symmetry and disorder 显示文摘 | DALBY M J GADEGAARD N TARE R et at | 2007 | Nat Mater2007，6，12： | 1 |
| 15 | Injection moulding difficult nanopatterns with hybrid polymer inlays显示文摘 | STORMONTH-DARLING J M GADEGAARD N | 2012 | Macromolecular Materials and Engineering2012，37，10： | 1 |
| 16 | Cells react to nan-cale order and symmetry in their surroundings显示文摘 | Curtis AS Gadegaard N Dalhy MJ | 2004 | IEEE Trans Nanobioscience2004，3，1： | 1 |
| 17 | The control of human mesenchymal cell differentiation using nanoscale symmetry and disorder显示文摘 | Dalby MJ Gadegaard N Tare R | | 0，，12： | 1 |
| 18 | Biodegradable micro- grooved polymeric surfaces obtained by photolithography for skele- tal muscle cell orientation and myotube development 显示文摘 | Altomare L Gadegaard N Visai L | 2010 | Acta Biomaterialia2010，6，6： | 1 |
| 19 | Biomimetic polymer nanostructures by injection molding显示文摘 | GADEGAARD N MOSLER S LARSEN N B | 2003 | Macromolecular Materials and Engineering2003，288，1： | 1 |
| 20 | The control of hu- man mesenchymal cell differentiation using nanoscale symmetry and disorder 显示文摘 | Dalby MJ Gadegaard N Tare R | 2007 | Nat Mater2007，6，12： | 1 |
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