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| 1 | Comparative cytotoxicity of fourteen trivalent and pentavalent arsenic species determined using real-time cell sensing显示文摘The occurrence of a large number of diverse arsenic species in the environment and in biological systems makes it important to compare their relative toxicity. The toxicity of arsenic species has been examined in various cell lines using different assays, making comparison difficult. We report real-time cell sensing of two human cell lines to examine the cytotoxicity of fourteen arsenic species: arsenite(As~Ⅲ), monomethylarsonous acid(MMA~Ⅲ) originating from the oxide and iodide forms, dimethylarsinous acid(DMA~Ⅲ), dimethylarsinic glutathione(DMAG~Ⅲ), phenylarsine oxide(PAO~Ⅲ), arsenate(AsV), monomethylarsonic acid(MMA~Ⅴ), dimethylarsinic acid(DMA~Ⅴ),monomethyltrithioarsonate(MMTTA~Ⅴ), dimethylmonothioarsinate(DMMTA~Ⅴ),dimethyldithioarsinate(DMDTA~Ⅴ), 3-nitro-4-hydroxyphenylarsonic acid(Roxarsone, Rox),and 4-aminobenzenearsenic acid(p-arsanilic acid, p-ASA). Cellular responses were measured in real time for 72 hr in human lung(A549) and bladder(T24) cells. IC50 values for the arsenicals were determined continuously over the exposure time, giving rise to IC50 histograms and unique cell response profiles. Arsenic accumulation and speciation were analyzed using inductively coupled plasma-mass spectrometry(ICP-MS). On the basis of the 24-hr IC50 values, the relative cytotoxicity of the tested arsenicals was in the following decreasing order: PAO~Ⅲ? MMA~Ⅲ≥ DMA~Ⅲ≥ DMAG~Ⅲ≈ DMMTA~Ⅴ≥ As~Ⅲ? MMTTA~Ⅴ> AsV> DMDTA~Ⅴ>DMA~Ⅴ> MMA~Ⅴ≥ Rox ≥ p-ASA. Stepwise shapes of cell response profiles for DMA~Ⅲ, DMAG~Ⅲ,and DMMTA~Ⅴcoincided with the conversion of these arsenicals to the less toxic pentavalent DMA~Ⅴ. Dynamic monitoring of real-time cellular responses to fourteen arsenicals provided useful information for comparison of their relative cytotoxicity. | Birget Moe Hanyong Peng Xiufen Lu Baowei Chen Lydia W.L.Chen Stephan Gabos Xing-Fang Li X.Chris Le | 2016 | Journal of Environmental Sciences2016，28，11： | 19 |
| 2 | Microelectronic cell sensor assayfor detection of cytotoxicity and prediction of acute toxicity 显示文摘 | Xing JZ Zhu L Gabos S | 2006 | Toxicol in Vitro2006，20，6： | 1 |
| 3 | Occlusion of dentinal tubules by iontobhuretic application of Soclium Fluorid 显示文摘 | Gangarosa LP Sr Gabo M Barapz RS | 1985 | J Dent Res1985，64，： | 1 |
| 4 | Treatment strategies in congenital scoliosis显示文摘 | Gabos PG | 2005 | Contemporary Spine Surgery2005，6，： | 1 |
| 5 | Long-term follow-up of female patients with idiopathic scoliosis treated with the Wilmington orthosis 显示文摘 | Gabos PG Bojescul JA Bowen JR | 2004 | J Bone Joint Surg Am2004，86，9： | 1 |
| 6 | Validation of urinary tri- chloroacetic as a biomarker of to drinking water disinfection by- products 显示文摘 | Zhang W Gabos S Schopnocher D | 2009 | J WaterHealth2009，7，3： | 1 |
| 7 | The Canadian Association of Radiation Oncology Scope of Practice Guidelines for Lung, Liver and Spine Stereotactic Body Radiotherapy显示文摘 | A. Sahgal D. Roberge D. Schellenberg T.G. Purdie A. Swaminath J. Pantarotto E. Filion Z. Gabos J. Butler D. Letourneau G.L. Masucci L. Mulroy A. Bezjak L.A. Dawson M. Parliament | 2012 | Clinical Oncology2012，，9： | 1 |
| 8 | Difficult thoracic pedicle screw placement in adolescent idiopathic scoliosis显示文摘 | Senaran H Shah SA Gabos PG | | 0，，03： | 1 |
| 9 | The association between biological subtype and locoregional recurrence in newly diagnosed breast cancer显示文摘 | Gabos Z Thoms J Ghosh S | 2010 | Breast Cancer Res Treat2010，124，1： | 1 |
| 10 | Simplified skeletal maturity scoring system:learning curve and methods to improve reliability显示文摘 | Verma K Sitoula P Gabos P | 2014 | Spine2014，39，26： | 1 |
| 11 | Treatment strategies in congenital scoliosis 显示文摘 | Gabos PG | 2005 | Contempo- rary Spine Surgery2005，6，： | 1 |
| 12 | Long-term follow-up of female patients with idiopathic scoliosis treated with the Wilmington orthosis显示文摘 | Gabos PG Bojescul JA Bowen JR | 2004 | J Bone Joint Surg Am2004，86，9： | 1 |
| 13 | Difficult thoracic pedicle screw placement in adolescent idiopathic scoliosis显示文摘 | Senaran H Shah SA Gabos PG | 2008 | J Spinal Disord Tech2008，21，3： | 1 |
| 14 | Meta-analysis of progestin and estrogen receptors in human meningiomas显示文摘 | Gabos S Berkel J | | 0，，02： | 1 |
| 15 | Risk factors for Anterior Cruciate Ligament injury in skeletal y immature patients:analysis of intercondylar notch width using Magnetic Resonance Imaging显示文摘 | Domzalski M Grzelak P Gabos P | | 0，，05： | 1 |
| 16 | Long-term follow-up of female patient with idiopathic scoliosis treated with the Wilmington orthosis显示文摘 | Gabos P G Bojescul J A Bo wen J R | 2004 | J Bone Joint Surg Am2004，86，： | 1 |
| 17 | Treatment strategies in congenital scoliosis 显示文摘 | Gabos PG | 2005 | Contempo- rary Spine Surgery2005，6，： | 1 |
| 18 | Difficult thoracic pedicle screw placement in adolescent idiopathic scoliosis显示文摘 | Senaran H Shah SA Gabos PG | 2008 | J Spinal Disord Tech2008，21，3： | 1 |
| 19 | Some aspects of pepper virus research 显示文摘 | Kazinczi G Horvath J Gabo~anyi R | 2001 | Acta Phytopathologlca et Entomologlca2001，36，32： | 1 |
| 20 | Geology and geochemistry of the elastic sequences from Northwestern Panay (Philippines) : Implieations for provenance and geoteetonie setting显示文摘 | Gabo J A Dimalanta C B Asio M J | 2009 | Tectonophysics2009，479，： | 1 |
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