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18篇 您的检索式:作者名="GUSSIO R"
    题名 作者 年代 出处 被引量
1A common pharmacophore for epothilone and taxanes: Molecular basis for drug resistance conferred by tublin mutations in human cancer cells显示文摘Giannakakou P Gussio R Nogales E 2000Proc Natl Acad Sci USA2000,97,3:1
2Discovery and initial characterization of the paullones, a novel class of small-molecule inhibitors of cyclin-dependent kinases显示文摘ZAHAREVITZ D W GUSSIO R LEOST M 1999Cancer Res1999,59,:1
3A common pharmacophore for epothilone and taxanes: molecular basis for drug resistance conferred by tubulin mutations in human cancer cells显示文摘Giannakakou P Gussio R Nogales E 2000Proc Nat Acad Sci USA2000,97,6:1
4Structure-based design modifications of the paullone molecu- lar scaffold for cyclin-dependent kinase inhibition显示文摘GUSSIO R ZAHAREVITZ D W MCGRATH C F 2000Anti-Cancer Drug Design2000,15,:1
5A common pharmacophore for epothilone and taxanes:Molecular basis for drug resistanceconferred by tubulin mutations in human cancer cells显示文摘Giannakakou P Gussio R Nogales E 2000Biological Sciences Pharmacology2000,97,6:1
6Discovery and initial characterization of the paullones, a novel class of small-molecule inhibitors of cyclin-dependent kinases 显示文摘Zaharevitz DW Gussio R Leost M 1999Cancer Res1999,59,11:1
7Structure-based design modifications of the paullone molecular scaffold for cyclin-dependent kinase inhibition显示文摘Gussio R Zaharevitz DW McGrath CF 2000Anticancer Drug Des2000,15,1:1
8A common pharmacophore for epothilone and taxanes:Molecular basis for drug resistance conferred by tubulin mutations in human cancer cells显示文摘Giannakakou P Gussio R Noqales E 2000Proc Natl Acad Sci USA2000,97,6:1
9Homology model of RSK2 N-terminal kinase domain, structure-based identi- fication of novel RSK2 inhibitors, and preliminary common pharmacophore 显示文摘Nguyen TL Gussio R Smith JA 2006Bioorg Med Chem2006,14,17:1
10Homology model of RSK2 N-terminal kinase donmin, structure-based identification of novel RSK2 inhibitors, and preliminary common pharmacophore 显示文摘NGUTEN T L GUSSIO R SMITH J A 2006Bioorg Med Chem2006,14,17:1
11Discovery and initial characterization of the paullones,a novel class of small-molecule inhibitors of cyclin-dependent kinases显示文摘ZAHAREVITZ D W GUSSIO R LEOST M 1999Cancer Res1999,59,11:1
12The assembly-inducing laulimalide/peloruside a binding site on tubulin: moleeular modeling and biochemical studies with peloruside A 显示文摘Nguyen T L Xu X Gussio R 2010J Chem Inf Model2010,50,11:1
13A common pharmacophore for epothilone and taxanes:Molecular basis for drug resistance conferred by tubulin mutations in human cancer cells显示文摘Giannakakou P Gussio R Nogales E 2000Proc Natl Acad Sci U S A2000,97,:1
14Cell-Based and biochemical structure-activity analyses of analogs of the microtubule stabilizer dictyostatin 显示文摘Edler M C Buey R M Gussio R 2005Biochemistry2005,44,11:1
15A common pharmacophore for epothilone and taxanes: molecular basis for drug resistance conferred by tubulinmutations in human cancer cells显示文摘Giannakakou P Gussio R Nogales E 2000Proc Natl Acad Sci USA2000,97,2000:1
16Discovery and initial characterization of the paullones, a novel class of small- molecule inhibitiors of cyclin- dependent kinases显示文摘Zaharevitz W Gussio R Leost M 1999Cancer Res1999,59,:1
17A common pharmacophore for epothilone and taxanes:molecular basis for drug resistance conferred by tubulin mutations in human cancer cells显示文摘GIANNAKAKOU P GUSSIO R NOGALES E 2000Proc Natl Acad Sci U S A2000,97,6:1
18Epoxide-containing side chains enhance antiproliferative activity of paullones显示文摘Xie X Lemcke T Gussio R 2005Eur J Med Chem2005,40,7:1
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