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| 1 | Neoadjuvant hyperfractionated accelerated radiotherapy plus concomitant 5-fluorouracil infusion in locally advanced rectal cancer: A phase Ⅱ study显示文摘AIM To evaluate the efficacy and tolerability of neoadjuvant hyperfractionated accelerated radiotherapy(HART)and concurrent chemotherapy in patients with locally advanced infraperitoneal rectal cancer. METHODS A total of 30 patients with histopathologically confirmed T2-3/N0+ infraperitoneal adenocarcinoma of rectum cancer patients received preoperative 42 Gy/1.5 Gy/18 days/bid radiotherapy and continuous infusion of 5-fluorouracil(325 mg/m^2). All patients were operated 4-8 wk after neoadjuvant concomitant therapy. RESULTS In the early phase of treatment, 6 patients had grade Ⅲ-Ⅳ gastrointestinal toxicity, 2 patients had grade Ⅲ-Ⅳ hematologic toxicity, and 1 patient had grade Ⅴ toxicity due to postoperative sepsis during chemotherapy. Only 1 patient had radiotherapy-related late side effects, i.e., grade Ⅳ tenesmus. Complete pathological response was achieved in 6 patients(21%), while near-complete pathological response was obtained in 9(31%). After a median follow-up period of 60 mo, the local tumor control rate was 96.6%. In 13 patients, distant metastasis occurred. Disease-free survival rates at 2 and 5 years were 63.3% and 53%, and corresponding overall survival rates were 70% and 53.1%, respectively.CONCLUSION Although it has excellent local control and complete pathological response rates, neoadjuvant HART concurrent chemotherapy appears to not be a feasible treatment regimen in locally advanced rectal cancer, having high perioperative complication and intolerable side effects. Effects of reduced 5-fluorouracil dose or omission of chemotherapy with the aim of reducing toxicity may be examined in further studies. | Zeynep Gural Sezer Saglam Serap Yucel Esra Kaytan-Saglam Oktar Asoglu Cetin Ordu Hediye Acun Rasul Sharifov Semen Onder Ahmet Kizir Ethem N Oral | 2018 | World Journal of Gastrointestinal Oncology2018，10，1： | 3 |
| 2 | Power ion battery:bridging the gap between Li-ion and supercapacitor chemistries显示文摘 | PASQUIER A D PLITZ I GURAL J | | 0，，01： | 1 |
| 3 | Li2MnSiO4/activated carbonhybrid supercapacitor显示文摘 | Plitz I Badway F Gural J | 2006 | Appl Phys A2006，82，： | 1 |
| 4 | Power - ion battery : bridging the gap between Li - ion and supercapacitor chemistries 显示文摘 | Du Pasquier A Plitz I Gural J | 2004 | Journal of Power Sources2004，136，1： | 1 |
| 5 | Characteristic and performance of 500 F asymmetric cybrid advanced supercapaeitor protoypes 显示文摘 | Aurelien P Irene P Gural J | 2003 | Power Sources2003，113，： | 1 |
| 6 | Characteristics and performance of 500 F asymmetric hybrid advanced supercapacitor prototypes显示文摘 | PASQUIER A D PLITZ I GURAL J | | 0，，01： | 1 |
| 7 | Characteristics and performance of 500 F asymmetric hybrid advanced supercapacitor prototypes显示文摘 | Pasquier A D Plitz 1 Gural J | 2003 | J Power Sources2003，113，1： | 1 |
| 8 | Intramolecular Hydrogen Abstraction in Radicals Derived from Inositol1,3-Acetals: Efficient Access to Cyclitols 显示文摘 | Murali C Gurale B P Shashidhar M S | 2010 | Eur J Org Chem2010，4，： | 1 |
| 9 | Characteristics and performance of 500 F asymmetric hybrid advanced supercapacitor prototypes 显示文摘 | Aurelien D P Plitz I Gural J | 2003 | J Power Sources2003，113，1： | 1 |
| 10 | Immune disorders in women with premature ovarian failure in initial period显示文摘 | Chernyshov VP Radysh TV Gural V | 2001 | Am J Reprod Immunol2001，46，3： | 1 |
| 11 | A trifungal infection of the mandible: Case report and literature review显示文摘 | Nilly Lador Itzhack Polacheck Alexander Gural Ekatrina Sanatski Adrian Garfunkel | 2006 | Oral Surgery Oral Medicine Oral Pathology Oral Radiology and Endodontology2006，，4： | 1 |
| 12 | Power-ion battery:bridging the gap between Li-ion and supercapacitorchemistries显示文摘 | Pasquier A D Plitz I Gural J | 2004 | J Power Sources2004，136，： | 1 |
| 13 | Comparision of intermittent pneumatic compression with manual lymphatic drainage for treatment of breast cancer-related lymphede- ma 显示文摘 | Gural SO Kostanoglu A Cavdar L | 2012 | Lymphatic Res Biol2012，10，3： | 1 |
| 14 | Short communication:bendamustine-related hemolytic anemia in chronic lymphocytic leukemia显示文摘 | Goldschmidt N Gural A Ben-Yehuda D | 2013 | Cancer Chemother Pharmacol2013，72，3： | 1 |
| 15 | Characteristics and per- formance of 500 F asymmetric hybrid advanced supercapacitor proto-types 显示文摘 | PASQUIER A D PLITZ I GURAL J | 2003 | Journal of Power Sources2003，113，： | 1 |
| 16 | Power-ion battery : bridging the gap between Li-ion and supercapacitor chemistries显示文摘 | Paspuier A D Plitz I Gural J | 2004 | J Power Sources2004，136，1： | 1 |
| 17 | A trifungal infection of the mandible: Case report and literature review显示文摘 | Lador N Polacheck I Gural A | 2006 | Oral Surg Oral Med Oral Pathol Oral Radiol Endod2006，101，4： | 1 |
| 18 | Stromal PRs mediate induction of 17beta-hydroxysteroid dehydrogenase type 2 in human endometrial epithelium: a paracfine mechanism for inactivation of E2显示文摘 | Yang S Fang Z Gurales B el al | 2001 | Mol Endocrinol2001，15，12： | 1 |
| 19 | Power-ion battery:Bridging the gap between Li-ion and supercapacitor chemistries显示文摘 | PASQUIER A D PLITZ I GURAL J BADWAY F AMATUCCI G G | 2004 | J Power Sources2004，136，1： | 1 |
| 20 | 显示文摘 | Pasquier A D Plitz I Gural J | 2003 | Journal of Power Sources2003，113，： | 1 |
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