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| 1 | Phase I study of chimeric anti-CD20 monoclonal antibody in Chinese patients with CD20-positive non-Hodgkin's lymphoma显示文摘Objective: This study was designed to determine the safety, pharmacokinetics and biologic effects of a humanmouse chimeric anti-CD20 monoclonal antibody(SCT400) in Chinese patients with CD20-positive B-cell nonHodgkin's lymphoma(CD20+ B-cell NHL). SCT400 has an identical amino acid sequence as rituximab, with the exception of one amino acid in the CH1 domain of the heavy chain, which is common in Asians.Methods: Fifteen patients with CD20+ B-cell NHL received dose-escalating SCT400 infusions(250 mg/m^2: n=3; 375 mg/m^2: n=9; 500 mg/m^2: n=3) once weekly for 4 consecutive weeks with a 24-week follow-up period. The data of all patients were collected for pharmacokinetics and pharmacodynamics analyses.Results: No dose-limiting toxicities were observed. Most drug-related adverse events were grade 1 or 2. Two patients had grade 3 or 4 neutropenia. Under premedication, the drug-related infusion reaction was mild. A rapid, profound and durable depletion of circulating B cells was observed in all dose groups without significant effects on T cell count, natural killer(NK) cell count or immunoglobulin levels. No patient developed antiSCT400 antibodies during the course of the study. SCT400 serum half-life(T1/2), maximum concentration(Cmax) and area under the curve(AUC) generally increased between the first and fourth infusions(P<0.05). At the 375 mg/m^2 dose, the T1/2 was 122.5±46.7 h vs. 197.0±75.0 h, respectively, and the Cmax was 200.6±20.2 μg/m L vs. 339.1±71.0 μg/m L, respectively. From 250 mg/m^2 to 500 mg/m^2, the Cmax and AUC increased significantly in a dose-dependent manner(P<0.05). Patients with a high tumor burden had markedly lower serum SCT400 concentrations compared with those without or with a low tumor burden. Of the 9 assessable patients, 1 achieved complete response and 2 achieved partial responses.Conclusions: SCT400 is well-tolerated and has encouraging preliminary efficacy in Chinese patients with CD20+ B-cell NHL. | Lin Gui Xiaohong Han Xiaohui He Yuanyuan Song Jiarui Yao Jianliang Yang Peng Liu Yan Qin Shuxiang Zhang Weijing Zhang Wenlin Gai Liangzhi Xie Yuankai Shi | 2016 | Chinese Journal of Cancer Research2016，28，2： | 5 |
| 2 | Autologous peripheral blood stem cell mobilization following dose-adjusted cyclophosphamide, doxorubicin, vincristine and prednisolone chemotherapy alone or in combination with rituximab in treating high-risk non-Hodgkin's lymphoma显示文摘Background: The regimen of cyclophosphamide, doxorubicin, vincristine, and prednisolone(CHOP) is an eicient treatment of non-Hodgkin's lymphoma(NHL). This study aimed to assess the eicacy and toxicity of dose-adjusted CHOP alone or in combination with rituximab(R-CHOP) by examining the stem cell mobilization in NHL patients. Factors afecting the collection of CD34+ cells were also explored.Methods: Our retrospective study included 39 patients eligible for autologous stem cell transplantation: 14 patients who expressed CD20 and were inancially eligible received R-CHOP for autologous peripheral blood stem cell(APBSC) mobilization; the remaining 25 patients received CHOP.Results: The median CD34+ cell yield was 7.01 × 106 cells/kg body weight(range 1.49–28.39 × 106 cells/kg body weight), with only two patients failing to meet the target CD34+ cell harvest of ber of apheresis procedures per patient was 1(range 1–3). The≥2.0 APBS× 106 cells/kg body weight. The median numC mobilization yield of the CHOP group appeared to be higher than that of the R-CHOP group(P response(CR) rate in = 0.005), whereas the success rate was similar between groups. R-CHOP elevated the completeB cell lymphoma patients as compared with CHOP(P = 0.01). No signiicant diferences in toxicity or engraftment were observed between the two groups.Conclusion: The present study demonstrated that dose-adjusted CHOP chemotherapy efectively mobilized APBSCs in NHL patients and that the addition of rituximab to dose-adjusted CHOP chemotherapy elevated the CR rate for patients with B-cell lymphoma. | Yuankai Shi Ping Zhou Xiaohong Han Xiaohui He Shengyu Zhou Peng Liu Jianliang Yang Changgong Zhang Lin Gui Yan Qin Sheng Yang Liya Zhao Jiarui Yao Shuxiang Zhang | 2015 | Chinese Journal of Cancer2015，34，11： | 4 |
| 3 | Two-Dimensional Transient Thermal Analysis of a Phase-Change-Material Canister of a Heat-Pipe Receiver under Gravity显示文摘High-temperature Phase Change Material (PCM) is used as a thermal storage medium of a heat-pipe receiver in an advanced solar dynamic system.With both void cavity and natural convection considered,thermal performance of the heat-pipe receiver is numerically analyzed under gravity.The results indicate that the PCM contained in the integrated heat pipe performs an averaging function of heat loadings.The thermal performance of the heat-pipe receiver is stable and reliable.When a heating cycle is stable,the temperature fluctuations both on heat-pipe wall and in PCM canister remain less than 13 K throughout a sunlight and eclipse cycle.The utility of PCM is essentially improved.The maximum melting ratio of PCM is 92%.Under gravity,PCM melts more quickly with the effect of natural convection.Natural convection accelerates the process of phase changes.Numerical results are compared with the experimental results concerned.The accuracy of numerical model under gravity is verified.The experiment for the PCM canister on the ground can be well prepared with our numerical simulation. | Xiaohong GUI Wei QU Bin LIN Xiugan YUAN | 2010 | Journal of Thermal Science2010，19，2： | 3 |
| 4 | Early ABA-stimulated maintenance of Cl^(−) homeostasis by mepiquat chloride priming confers salt tolerance in cotton seeds显示文摘Mepiquat chloride(MC)priming alleviates the effects of salt stress during seed germination in cotton(Gossypium hirsutum L.),but the mechanisms underlying its effects are unknown.We found that MC priming increases salt tolerance,as evidenced by marked increases in seed vigor and germination rates,and alleviated salt toxicity by reducing Cl^(−)accumulation in germinating seeds.Consistently,electrophysiological experiments revealed that the seeds with MC priming displayed superior Cl^(−)exclusion ability in the root apex.These beneficial effects of MC priming were abolished by the abscisic acid(ABA)-synthesis blocker fluridone under salt stress.MC priming induced an early response to acclimatization and stress,as indicated by rapidly increasing ABA content during initial exposure to salt stress.Transcriptome analyses revealed that MC priming induced an array of differentially expressed genes(DEGs)in germinating seeds.The most noticeable changes in germinating seeds were MC priming-induced increases in the expression of DEGs encoding components of ABA biosynthesis,ABA catabolism,and ABA signaling pathways under salt stress.MC priming also increased the expression of some DEGs encoding Cl^(−)ion transporters(e.g.CCC,SLAC1/SLAH1/SLAH3,CLC,and ALMT9)in germinating seeds.These results indicate that MC priming-induced ABA contributes to Cl^(−)homeostasis in tissues and acts as a positive regulator of salt tolerance via regulation of Cl^(−)transporters(particularly CCC and SLAC1/SLAH1/SLAH3).Taken together,these findings shed light on the molecular mechanism underlying MC-mediated tolerance to salt stress during seed germination. | Ning Wang Xiangru Wang Hengheng Zhang Xiaohong Liu Jianbin Shi Qiang Dong Qinghua Xu Huiping Gui Meizhen Song Gentu Yan | 2021 | The Crop Journal2021，9，2： | 2 |
| 5 | Thermodynamic Performances of[mmim]DMP/Methanol Absorption Refrigeration显示文摘In order to study the theoretical cycle characteristic of [mmim]DMP(1-methyl-3-methylimidazolium dimethylphosphate)/methanol absorption refrigeration,the modified UNIFAC group contribution model and the Wilson model are established through correlating the experimental vapor pressure data of [mmim]DMP/methanol at T=280~370K and methanol mole fraction x=0.529~0.965.Thermodynamic performances of absorption refrigeration utilizing [mmim]DMP/methanol,LiBr/H2O and H2O/NH3 are investigated and compared with each other under the same operating conditions.From the results,some conclusions are obtained as follows:1)the circulation ratio of the [mmim]DMP /methanol absorption refrigeration is higher than that of the LiBr/H2O absorption refrigeration,but still can be acceptable and tolerable.2)The COP of the [mmim]DMP/methanol absorption refrigeration is smaller than that of the LiBr/H2O absorption refrigeration,while it is higher than that of the H2O/NH3 absorption refrigeration under most operating conditions.3)The[mmim]DMP/methanol absorption refrigeration are still available with high COP when the heat source temperature is too high to drive LiBr/H2O absorption refrigeration. | Wei Chen Shiqiang Liang Yongxian Guo Keyong Cheng Xiaohong Gui Dawei Tang | 2012 | Journal of Thermal Science2012，21，6： | 2 |
| 6 | A multi-center,open-label,randomized,parallel-controlled phase II study comparing pharmacokinetic,pharmacodynamics and safety of ripertamab(SCT400)to rituximab(Mab Thera?)in patients with CD20-positive B-cell non-Hodgkin lymphoma显示文摘Objective:This multi-center,open-label,randomized,parallel-controlled phaseⅡstudy aimed to compare the pharmacokinetics(PK),pharmacodynamics(PD)and safety profile of ripertamab(SCT400),a recombinant antiCD20 monoclonal antibody,to rituximab(MabThera^(■))in patients with CD20-positive B-cell non-Hodgkin lymphoma(NHL).Methods:Patients with CD20-positive B-cell NHL who achieved complete remission or unconfirmed complete remission after standard treatment were randomly assigned at a 1:1 ratio to receive a single dose of ripertamab(375mg/m^(2))or rituximab(MabThera^(■),375 mg/m^(2)).PK was evaluated using area under the concentration-time curve(AUC)from time 0 to d 85(AUC_(0-85d)),AUC from time 0 to week 1(AUC0-1 w),AUC from time 0 to week 2(AUC_(0-2 w)),AUC from time 0 to week 3(AUC_(0-3 w)),AUC from time 0 to week 8(AUC_(0-8 w)),maximum serum concentration(C_(max)),terminal half-life(T_(1/2)),time to maximum serum concentration(T_(max))and clearance(CL).Bioequivalence was confirmed if the 90%confidence interval(90%CI)of the geometric mean ratio of ripertamab/rituximab was within the pre-defined bioequivalence range of 80.0%-125.0%.PD,immunogenicity,and safety were also evaluated.Results:From December 30,2014 to November 24,2015,a total of 84 patients were randomized(ripertamab,n=42;rituximab,n=42)and the PK analysis was performed on 76 patients(ripertamab,n=38;rituximab,n=38).The geometric mean ratios of ripertamab/rituximab for AUC_(0-85d),ATC_(0-inf),and Cmaxwere 96.1%(90%CI:87.6%-105.5%),95.9%(90%CI:86.5%-106.4%)and 97.4%(90%CI:91.6%-103.6%),respectively.All PK parameters met the pre-defined bioequivalence range of 80.0%-125.0%.For PD and safety evaluation,there was no statistical difference in peripheral CD 19-positive B-cell counts and CD20-positive B-cell counts at each visit,and no difference in the incidence of anti-drug antibodies was observed between the two groups.The incidences of treatment-emergent adverse events and treatment-related adverse events were also comparable between the two groups.Conclusions:In this study,the PK,PD,immunogenicity,and safety profile of ripertamab(SCT400)were similar to rituximab(MabThera^(■))in Chinese patients with CD20-positive B-cell NHL. | Xiaohong Han Mingzhi Zhang Huaqing Wang Qingyuan Zhang Wei Li Miaowang Hao Yuhuan Gao Jie Jin Hanyun Ren Yun Tang Xiaonan Hong Xiaoyan Ke Hang Su Lin Gui Jianmin Luo Liangzhi Xie Wenlin Gai Yuankai Shi | 2022 | Chinese Journal of Cancer Research2022，34，6： | 1 |
| 7 | Flame retardant synergism of rubber and Mg(OH)2 in EVA composites显示文摘 | Gui Hua Zhang Xiaohong Dong Weifu | 2007 | Polymer2007，，48： | 1 |
| 8 | Flame retard- ant synergism of rubber and Mg(OH) 2 in EVA composites 显示文摘 | Gui Hua Zhang Xiaohong Dong Weifu | 2007 | Polymer2007，48，9： | 1 |
| 9 | Effect of dispersion of nano-magnesium hydroxide on the flammability of flame retardant ternary composites 显示文摘 | Gui Hua Zhang Xiaohong Liu Yiqun | 2007 | Composite Science and Technology2007，67，6： | 1 |
| 10 | Flame retardant synergism of rubber and Mg(OH)2in EVA composites显示文摘 | Gui Hua Zhang Xiaohong Dong Weifu | | 0，，09： | 1 |
| 11 | Effect of dispersion of nano -magnesium hydroxide on the ammability of flame retardant ternary composites显示文摘 | Hua Gui Xiaohong Zhang Yiqun Liu | 2007 | Compsites Science and Technology2007，67，： | 1 |
| 12 | Effect of dispersion of nano -magnesium hydroxide on the flammability of flame retardant ternary composites 显示文摘 | Hua Gui Xiaohong Zhang Yiqun Liu | 2007 | Composites Science and Technology2007，67，： | 1 |
| 13 | 显示文摘 | Gui Hua Zhang Xiaohong | 2007 | Composites Science and Technology2007，67，： | 1 |
| 14 | Development and Test of Combustion Chamber for Stirling Engine Heated by Natural Gas显示文摘燃烧房间是为天然气加热的 Stirling 引擎的一个重要部件。在纸,我们为试图产生 35 kWe 电力的 Stirling 引擎开发一个燃烧房间。燃烧房间包括三个主要部件:燃烧模块,热交换洞和热头。它的特征是结构能把燃烧过程和热转移过程划分成二明显的单个步并且让他们一个一个地发生。因为天然气能在烧前充分与空气混合,没有第二风,燃烧过程能容易被完成。火焰能避免联系 Stirling 引擎,和温度的热头地能容易被控制。设计燃烧房间被生产,它的表演被包括二步的一个实验测试。第一步的试验性的结果证明空气和天然气的混合能容易被点燃,火焰稳定地烧。在实验的第二步,燃烧热流动能到达 20 kW,并且热头的精力利用效率超过了 0.5。这些测试结果证明燃烧房间的热表演到达了设计目标。设计燃烧房间能被用于是产生 35 kWe 电力的天然气加热的一台真实 Stirling 引擎。 | LI Tie SONG Xiange GUI Xiaohong TANG Dawei LI Zhigang CAO Wenyu | 2014 | Journal of Thermal Science2014，23，2： | 1 |
| 15 | Thermal Analysis of Void Cavity for Heat Pipe Receiver under Microgravity显示文摘Based on theoretical analysis of PCM(Phase Change Material) solidification process, the model of improved void cavity distribution tending to high temperature region is established. Numerical results are compared with NASA(National Aeronautics and Space Administration) results. Analysis results show that the outer wall temperature, the melting ratio of PCM and the temperature gradient of PCM canister, have great difference in different void cavity distribution. The form of void distribution has a great effect on the process of phase change. Based on simulation results under the model of improved void cavity distribution, phase change heat transfer process in thermal storage container is analyzed. The main goal of the improved designing for PCM canister is to take measures in reducing the concentration distribution of void cavity by adding some foam metal into phase change material. | GUI Xiaohong SONG Xiange NIE Baisheng | 2017 | Journal of Thermal Science2017，26，2： | 1 |
| 16 | Effect of dispersion of nano-magnesium hydroxide on the flammability of flame retardant ternary composites显示文摘 | Gui Hua Zhang Xiaohong Liu Yiqun | 2007 | Comps it es Science and Technology2007，67，： | 1 |
| 17 | Flame retardant synergism of rubber and Mg ( OH ) 2 in EVA composites 显示文摘 | Gui Hua Zhang Xiaohong | 2007 | Polymer2007，48，9： | 1 |
| 18 | Flame retardant synergism of rubber and Mg(OH)2 in EVA composites显示文摘 | Gui Hua Zhang Xiaohong Dong Weifu | 2007 | Polymer Communication2007，48，： | 1 |
| 19 | Thermal analysis on void cavity of heat pipe receiver in advanced solar dynamic system显示文摘 | Gui Xiaohong Yuan Xiugan | 2008 | Journal of Aeronautics Astronautics and Aviation2008，40，4： | 1 |
| 20 | Effect of dispersion of nano-magnesium hydroxide on the flammability of flame retardant ternary composites 显示文摘 | Gui Hua Zhang Xiaohong Liu Yiqun et a| | 2007 | Composite Seience and Technology2007，67，6： | 1 |
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