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| 1 | Col10a1 gene expression and chondrocyte hypertrophy during skeletal development and disease显示文摘类型 X 骨胶原基因, COL10A1,被 hypertrophic chondrocytes 明确地在 endochondral 期间表示骨化。Endochondral 骨化是包含软骨中介并且在 skeletogenesis 期间在脊椎动物导致大多数骨骼的形成的一个协调得好的过程。Chondrocyte 肥大是连接骨头和软骨开发的 endochondral 骨化的一个批评阶段。与 chondrocyte 肥大给它的特定的协会,在 endochondral 的类型 X 骨胶原戏必需品角色骨化。当变化和人的 COL10A1 的反常表示引起反常 chondrocyte 在许多骨胳的混乱被看见了的肥大时,有变异的类型 X 骨胶原的转基因的鼠标开发显示有缺点的 endochondral 骨化的可变骨骼造血的畸形,这以前被显示出当变化和人的 COL10A1 的反常表示引起反常 chondrocyte 在许多骨胳的混乱被看见了的肥大时。在这评论,我们与显示出生长板缺点的 COL10A1 基因变化总结了骨胳的 chondrodysplasia。我们也考察了相关的最近的研究有骨关节炎的类型 X 骨胶原基因表示和 chondrocyte 肥大。由于它的重要临床的关联,类型 X 骨胶原基因规定广泛地在过去的二十年被学习了。这里,我们集中于描绘 cis 提高元素和他们有约束力的因素的最近的进步一起授与 hypertrophic chondrocyte 特定的鼠科的类型 X 骨胶原基因(Col10a1 ) 表示。基于文学评论和我们的自己的研究,我们推测有多重因素,贡献 hypertrophic chondrocyte 特定的 Col10a1 表示。这些因素包括两 transactivators (例如 Runx2, MEF2C 等等) 并且抑压者(例如 AP1, NFATc1, Sox9 等等) ,当 Col10a1 表示的另外的余因子或 epigenetic 控制不能被排除时。 | Yaojuan LU Longwei QIAO Guanghua LEI Ranim R. MIRA Junxia GU Qiping ZHENG | 2014 | Frontiers in Biology2014，9，3： | 2 |
| 2 | Segmentation and Recognition System of Handwritten Chinese Bank Check Amounts显示文摘 | GU Junxia LIU Changsong DING Xiaoqing WANG Kongqiao | 2008 | Chinese Journal of Electronics2008，17，1： | 1 |
| 3 | Preparation and characterization of some surface negatively charged residue mutants of cytochrome b_5显示文摘Site-directed mutagenesis was used to obtain seven variants of tryptic fragment of bovine liver cytochrome bs (cyt bs), in which the negatively charged residues around the heme exposed edge of cyt bs were replaced by hydropho-bic amino acid alanine. Double-site mutants, triple-site mutants and even quadruple-site mutants were obtained. DNA sequencing and molecular weight measurements of the mutant proteins both confirmed that these site-directed muta-genesises were successfully performed. Spectroelectrochem-istry of these mutant proteins revealed that the apparent redox potentials of these mutant proteins caused a positive shift of 2-10 mV. The global structure of these mutant proteins did not show much difference from that of the wild type cyt bs, providing a solid base for the further study on the roles of the proteins’ surface charges. | WANG Yunhua, WANG Wenhu, LU Junxia, REN Yi, GU Shaohua, XIE Yi & HUANG Zhongxian1. Chemical Biology Lab, Department of Chemistry, Fudan University, Shanghai 200433, China 2. Genetic Institute, School of Life, Fudan University, Shanghai 200433, China | 2001 | Chinese Science Bulletin2001，46，7： | 1 |
| 4 | Multiwalledcarbon nanotubes coated fibers for solid-phase microextraction of poly- brominated diphenyl ethers in waterand milk samples before gas chroma- tography withelectron-capture detection显示文摘 | WANG Junxia JIANG Dongqing GU Zhiyuan | 2006 | Journal of Chromatography A2006，1137，1： | 1 |
| 5 | Wear properties and mechanisms of nylon and carbon-fiber-reinforced nylon in dry and wet con- ditions 显示文摘 | Wang Junxia Gu Mingyuan | 2004 | Journal of Applied Polymer Science2004，93，2： | 1 |
| 6 | Human Elongator complex is involved in cell cycle and suppresses cell growth in 293T human embryonic kidney cells显示文摘Elongator 建筑群与 hyperphosphorylated RNA 聚合酶 II 被联系了并且被知道在 transcriptional 延伸,以及在 tRNA 修正和 exocytosis 起关键作用。然而,人的 Elongator 建筑群怎么调整细胞生长和细胞周期的特定的机制仍然保持不清楚。在房间生长上调查人的 Elongator 建筑群和它的效果的作文, 293T 房间被建立那稳定地 overexpressed Flag-Elp3 和 Flag-Elp4。由使用反旗帜 M2 抗体界限树脂,核心 Elongator 建筑群从房间被净化那稳定地 overexpressed Flag-Elp3。没有 Elongator 建筑群稳定地从房间被净化有 pFlagCMV4-Elp4 的 transfected。有趣地,细胞生长与 pFlagCMV4-Elp3 在 293T 细胞 transfected 被禁止。流动 cytometry 分析证明大多数稳定地, overexpressing Flag-Elp3 在 G1 被发现的房间上演,显示在为房间周期的规定的 G1 检查点的核心 Elongator 的一个角色。我们观察到增加的基础抄写和显著地提高的抄写在 293T 房间 overexpressing Flag-Elp3 由 VP16 刺激了。抄写能被 overexpressing synergistically 也激活 Elp3 和 Elp4。一起拿,而 Elp4, Elp5,和 Elp6 可能泛泛地联系并且和核心 Elongator 工作调整房间功能,我们的结果建议 Elp1, Elp2,和 Elp3 形成的核心 Elongator 建筑群是相当稳定的。 | Junxia Gu Dongmei Sun Qiping Zheng Xiaochun Wang Huicui Yang Jingcheng Miao Jingting Jiang Wenxiang Wei | 2009 | Acta Biochimica et Biophysica Sinica2009，41，10： | 1 |
| 7 | Action and gait recognition from recovered 3-D human joints显示文摘 | Gu Junxia Ding Xiaoqing Wang shengjin | 2010 | IEEE Trans on Systems Man and Cybernetics Part B2010，40，4： | 1 |
| 8 | Action recognition from arbitrary views using 3D-key-pose set显示文摘恢复三维(3D ) 从任意的看法的人的姿势顺序是很困难的,由于深度信息和自我吸藏的损失。在这份报纸,设置的看法无关的 3D-key-pose 从 3D 行动样品被选择,为代表并且认出从没有在照相机和题目之间的相对取向的任何限制的一个单身者或很少照相机的那些一样的行动的目的。首先,设置的 3D-key-pose 从训练从多重观点被造的行动样品的 3D 的 3D 人关节序列被选择。第二, 3D 钥匙姿势顺序,与观察顺序最好匹配,从 3D-key-pose 集合被选择代表任意的看法的观察顺序。3D 钥匙姿势顺序包含许多歧视的看法无关的关键姿势但是不能精确地在观察顺序描述每个框架的姿势。就上述原因而言,摆姿势并且行动动态在这份报纸分别地被建模。基于模范的嵌入和唯一的关键姿势的概率被使用为姿势性质建模。互补动态特征被提取为分享一样的姿势,但是有不同动态特征的这些行动建模。最后,这些行动模型被熔化从一个单身者或很少照相机认出观察顺序。建议途径的有效性与 IXMAS 数据集的实验被表明。 | Junxia GU Xiaoqing DING Shenjing WANG | 2012 | Frontiers of Electrical and Electronic Engineering in China2012，7，2： | 0 |
| 9 | Adaptive deinterlacing algorithm based on motion compensation显示文摘An adaptive deinterlacing algorithm based on motion compensation is presented. It consists of the detection of motion blocks, the adaptive motion estimation with Kalman filtering, and the motion compensation for motion blocks and field repetition for static blocks. The detection of motion blocks can accurately identify the motion blocks by using successive 4field images. The motion estimation module with Kalman filtering searches motion vectors only for motion blocks, and the search model is adaptive to motion velocity and acceleration. Two deinterlacing methods are adopted to satisfy the different requirements of motion blocks and static blocks. Compared with full search algorithm, the proposed algorithm greatly reduces the computational amount while keeping the performance approximately. | Gao Xinbo Gu Junxia | 2005 | Journal of Systems Engineering and Electronics2005，16，4： | 0 |
| 10 | Effect of vanadium on the microstructure and properties of metastable austenitic stainless steel AISI 301LN显示文摘In this study,the effect of vanadium on the microstructure and properties of the metastable austenitic stainless steel AISI 301LN was investigated.Results of the study show that the addition of vanadium can refine grains and increase the strength of AISI 301LN by solution treatment.After 60%cold-rolling reduction,the microstructure of the steel was composed of work-hardened austenite bands and deformation-inducedɑ′martensite.Considerable work-hardening and phase transformation strengthening occurred.After cold rolling and subsequent annealing,the deformation-inducedɑ′martensite was reversed into fine-grained austenite.The work-hardened austenite bands underwent recrystallization;however,the structure of the recrystallized austenite grains was coarser than that of the reversed ones.Simultaneously,the strength of the experimental steels decreased with the increase in annealing temperature.The pinning effect of precipitates of vanadium inhibited the growth of austenite grains.Thus,the desirable combination of strength and ductility was obtained by grain refinement. | HUANG Junxia GU Jiaqing | 2021 | Baosteel Technical Research2021，15，2： | 0 |
| 11 | Effect of the cold deformation regime on microstructure and mechanical properties of AISI 301LN stainless steel显示文摘This study analyzed the effect of cold-rolling reduction(in a wide range of 10%-80%) and subsequent annealing on the microstructure and mechanical properties of AISI 301 LN stainless steel.Results indicated the formation of shear bands and nucleation of strain-induced α'-martensite at their intersections.The volume fraction of α'-martensite increased with increase in cold-rolling reduction by the continuous growth of embryos.This,in turn,resulted in an increase in yield and tensile strengths.The reversion of α'-martensite to austenite occurred after subsequent annealing.The observed variation in the grain size of reversed austenite can be related to the annealing regime.A good combination of strength and ductility can be obtained upon annealing at 650℃ for 30 min.The effect of grain size on yield strength conformed to the Hall-Petch relationship in the entire range of our analysis. | HUANG Junxia YE Xiaoning GU Jiaqing | 2014 | Baosteel Technical Research2014，8，3： | 0 |
| 12 | Transcriptome Analysis of Schwann Cells at Various Stages of Myelination Implicates Chromatin Regulator Sin3A in Control of Myelination Identity显示文摘Enhancing remyelination after injury is of utmost importance for optimizing the recovery of nerve function.While the formation of myelin by Schwann cells(SCs)is critical for the function of the peripheral nervous system,the temporal dynamics and regulatory mechanisms that control the progress of the s lineage through myelination require further elucidation.Here,using in vitro co-culture models,gene expression profiling of laser capture-microdissected SCs at various stages of myelination,and multilevel bioinformatic analysis,we demonstrated that SCs exhibit three distinct transcriptional characteristics duringmyelination:the immature,promyelinating,and myelinating states.We showed that suppressor interacting 3a(Sin3A)and 16 other transcription factors and chromatin regulators play important roles in the progress of myelination.Sin3A knockdown in the sciatic nerve or specifically in SCs reduced or delayed the myelination of regenerating axons in a rat crushed sciatic nerve model,while overexpression of Sin3A greatly promoted the remyelination of axons.Further,in vitro experiments revealed that Sin3A silencing inhibited SC migration and differentiation at the promyelination stage and promoted SC proliferation at the immature stage.In addition,SC differentiation and maturation may be regulated by the Sin3A/histone deacetylase2(HDAC2)complex functionally cooperating with Sox10,as demonstrated by rescue assays.Together,these results complement the recent genome and proteome analyses of SCs during peripheral nerve myelin formation.The results also reveal a key role of Sin3A-dependent chromatin organization in promoting myelinogenic programs and SC differentiation to control peripheral myelination and repair.These findings may inform new treatments for enhancing remyelination and nerveregeneration. | Bin Zhang Wenfeng Su Junxia Hu Jinghui Xu Parizat Askar Shuangxi Bao Songlin Zhou Gang Chen Yun Gu | 2022 | Neuroscience Bulletin2022，38，7： | 0 |
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