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| 1 | Metastasized pancreatic carcinoma with neoadjuvant FOLFIRINOX therapy and R0 resection显示文摘Patients with metastasized carcinoma of the pancreas have a very poor prognosis, and long-term survival cannot be expected. This case report describes two patients with an initial diagnosis of metastatic pancreatic cancer, both with hepatic metastases and one with an additional peritoneal carcinomatosis. Initially, both patients were treated intravenously with the FOLFIRINOX chemotherapy regimen, consisting of 5-FU, folinic acid, irinotecan and oxaliplatin. Surprisingly, the FOLFIRINOX treatment resulted in complete resolution of the hepatic metastases in both patients, with no lesions detectable by computed tomography scan. Furthermore, treatment response included decreased diameter of the primary tumor in the tail of the pancreas and disappearance of the additional peritoneal carcinomatosis. Both patients were discussed by our multidisciplinary tumor board, which recommended surgical resections of the carcinoma. The R0 resection of the primary tumor was successful in both cases and, interestingly, the resected tissues showed no evidence of the hepatic metastases intraoperatively. In the first case, the patient received a postoperative 6-mo course of adjuvant chemotherapy with gemcitabine. In the second case, the patient continued to receive the FOLFIRINOX regimen for an additional 6 mo postoperatively. At 12 mo after the operation, a nonresectable retroperitoneal lymph node metastasis was detected in the first patient, whereas the second patient remained in complete remission at the time of this report(5 mo after the adjuvant therapy was discontinued). This case report is the first of its kind to describe two cases of hepatic metastatic pancreatic carcinoma that were resectable following treatment with FOLFIRINOX. Further studies are required to examine the role of FOLFIRINOX as a neoadjuvant treatment option in subgroups of patients with initially metastasized pancreatic carcinoma. | Sophie Schneitler Patric Krpil Jasmin Riemer Gerald Antoch Wolfram Trudo Knoefel Dieter Hussinger Dirk Graf | 2015 | World Journal of Gastroenterology2015，21，20： | 9 |
| 2 | Design and synthesis of malonic acid-based inhibitors of human neutrophi collngenase(MMP-8) 显示文摘 | Grams F Brandstetter H | 1998 | J Med Chem1998，41，3： | 1 |
| 3 | Elimination of the cardiac natriaretic pept~des B-type natriuret~c pept~de (BNP) and N-terminal proBNP by hemodialysis显示文摘 | Wahl HG Graf S Renz H | 2004 | C]in Chem2004，50，： | 1 |
| 4 | Uniform flow in a smoothopen channel显示文摘 | CardosoA H Graf W H Gust G | 1989 | Journal of Hydraulic Engineering1989，27，5： | 1 |
| 5 | Serotonin promotes tumor growth in human hepatocellular cancer显示文摘 | SOLL C JANG J H RIENER M O MORITZ W WILD P J GRAF R | 2010 | Hepatology2010，51，： | 1 |
| 6 | Photo-realistic talking heads from image samples 显示文摘 | COSATTO E GRAF H | 2000 | IEEE Trans on Multimedia2000，2，3： | 1 |
| 7 | Lcaaruitine substitution in patients on chronic hemodialysis 显示文摘 | Mayer G Graf H Legenstin E | 1989 | Nephron1989，52，： | 1 |
| 8 | Dopa-responsive dystonia simulating spastic paraplegia due to tyrosine hydroxylase (TH) gene mutations显示文摘 | Fkawa Y Graf WD Wong H | 2001 | Neurology2001，56，2： | 1 |
| 9 | Morphological differences in semicrystalline polymers: Implications for local dynamics and chain diffusion显示文摘 | Yao Y F Graf R Spiess H W | 2007 | Phys Rev E2007，76，06： | 1 |
| 10 | Compensation of magnetic field distortions from paramagnetic instruments by added diamagnetic material:measurements and numerical simulations显示文摘 | Muller-Bierl B Graf H Steidle G | 2005 | Med Phy2005，32，： | 1 |
| 11 | Uniform flow in a smooth open channel显示文摘 | Cardoso A H Graf W H Gust G | 1989 | Journal of Hydraulic Engineering ASCE1989，27，5： | 1 |
| 12 | The role of action representation in visual object显示文摘 | Helbig H B Graf M Kiefer M | | 0，，： | 1 |
| 13 | Influence of crystal thickness and topological constraints on chain diffusion in linear polyethylene显示文摘 | Yao Y F Graf R Spiess H W | 2009 | Macromol Rapid Commun2009，30，13： | 1 |
| 14 | The annual volcanic gas input into the atmosphere, in particular into the stratosphere a global data set for the past 100 years显示文摘 | Halmer M M Schmincke H U Graf H F | 2002 | Journal of Volcanology and Geothermal Research2002，115，： | 1 |
| 15 | Influence of crystal thickness and topological constraints on chain diffu- sion in linear polyethylene显示文摘 | Yao Y F Graf R Spiess H W | 2009 | Macromol Rapid Comm2009，30，13： | 1 |
| 16 | Lumbar instability: surgical treatment without fusion显示文摘 | Graf H | 1992 | Rachis1992，24，： | 1 |
| 17 | Structural behaviour of point-supported and clamped laminated glass显示文摘 | Graf H Albrecht G Sackmann V | 2004 | Structural Engineering International2004，14，2： | 1 |
| 18 | Clinical predictors for a high risk for the development of diabetes mel- litus in the early puerperium in women with recent gestational diabetes mellitus显示文摘 | SCHAEFER GRAF U M BUCHANAN T A XIANG A H | 2002 | Am J Obstet Gynecol2002，186，4： | 1 |
| 19 | L-carnitine substitution in patients on chronic hemodialysis 显示文摘 | Mayer G Graf H Legenstin E | 1989 | Nephron1989，52，： | 1 |
| 20 | Accumulation of dietary cholesterol in sitosterolemia caused by mutations in adjacent ABC transporters显示文摘 | BERGE K E TIAN H GRAF G A | 2000 | Sci2000，290，： | 1 |
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