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	题名	作者	年代	出处	被引量
1	The oral commensal Streptococcus mitis activates the aryl hydrocarbon receptor in human oral epithelial cells显示文摘Streptococcus mitis(S. mitis) is a pioneer commensal bacterial species colonizing many of the surfaces of the oral cavity in healthy individuals. Yet, not much information is available regarding its interaction with the host. We used examination of its transcriptional regulation in oral keratinocytes to elucidate some of its potential roles in the oral cavity. Transcription factor analysis of oral keratinocytes predicted S. mitis-mediated activation of aryl hydrocarbon receptor(Ah R). Activation and functionality of Ah R was confirmed through nuclear translocation determined by immunofluorescence microscopy and real-time polymerase chain reaction with reverse transcription analysis of CYP1A1, the hallmark gene for Ah R activation. Addition of Streptococcus mutans or Streptococcus gordonii did not induce CYP1A1 transcription in the keratinocyte cultures. Introduction of an Ah R-specific inhibitor revealed that S. mitis-mediated transcription of CXCL2 and CXCL8 was regulated by Ah R. Elevated levels of prostaglandin E2(enzyme-linked immunosorbent assay) in supernatants from S. mitis-treated oral epithelial cells were also attenuated by inhibition of Ah R activity. The observed Ah R-regulated activities point to a contribution of S. mitis in the regulation of inflammatory responses and thereby to wound healing in the oral cavity. The concept that the oral commensal microbiota can induce Ah R activation is important, also in view of the role that Ah R has in modulation of T-cell differentiation and as an anti-inflammatory factor in macrophages.	stian a engen gro h rørvik olav schreurs inger js blix karl schenck	2017	International Journal of Oral Science2017，9，3：	2
2	Interleukin-15 enhances innate and adaptive immune reponses to bloodstage malaria infection in mice显示文摘	Ing R Gros P Stevenson M M	2005	Infect Immun2005，73，5：	1
3	Plasma membrane calcium ATPase overexpression in arterial smooth muscle increases vasomotor responsiveness and blood pressure显示文摘	Gros R Afroze T You X M	2003	Circ Res2003，93，7：	1
4	Conditional cardiac overexpresssion of edothelin-1 induces inflammation and dilated cardiomyopathy in mice显示文摘	YANG LL GROS R KABIR MG	2004	Circulation2004，109，2：	1
5	Role of atypical antipsychotics in the treatment of generalized anxiety disorder 显示文摘	Hershenberg R Gros DF Brawman-Mintzer O	2014	CNS Drugs2014，28，6：	1
6	A role for endoglin in coupling eNOS activity and regulating vascular tone revealed in hereditary hemorrhagic telangiectasia 显示文摘	Toporsian M Gros R Kabir MG	2005	Cire Res2005，96，6：	1
7	Plasma membrane calcium ATPase overexpression in arterial smooth muscle increases vasomotor responsiveness and blood pressure 显示文摘	Gros R Afroze T You X-M	2003	Circ Res2003，93，：	1
8	Cardiomyocyte overexpression of iNOS in mice results in peroxynitrite generation, heart block,and sudden death显示文摘	Mungrue IN Gros R You X	2002	J Clin Invest2002，109，：	1
9	Conditional and targeted overexpression of vascular chymase causes hypertension in transgensic mice显示文摘	Ju H Gros R You X	2001	Proc Natl Acad Sci USA2001，98，13：	1
10	A role for endoglin incou- piing eNOS activity and regulating vascular tone revealed inhereditary hemorrhagic telangiectasia 显示文摘	Toporsian M Gros R Kabir MG	2005	Circ Res2005，96，6：	1
11	Variable selection in near infrared spectra for the biological characterization of soil and earthworm casts 显示文摘	Cecillon L Cassagne N Czarnes S Gros R Brun J J	2008	Soil Biology & Biochemistry2008，40，：	1
12	DBR waveguide laser in erbium-diffusion-doped LiNbO3显示文摘	GRO R BAUMANNN I	1995	Electron Lett1995，31，7：	1
13	Ligand selectivity of a synthetic CXCR4 mimetic peptide显示文摘	Gro? A Brox R Damm D	2015	Bioorg Med Chem2015，23，14：	1
14	Rapid vascular effects of steroids-a question of balance? 显示文摘	Feldman RD Gros R	2010	Can J Cardiol2010，26，：	1
15	Conditional cardiac overexpression of endothelin-I induces inflammation and dilated cardiomyopathy in mice 显示文摘	Yang L L Gros R Kabir G	2004	Circulation2004，109，：	1
16	Steam Soak Predictive Model显示文摘	Gros R P	1985	SPE142401985，，：	1
17	Cell motility and metastatic potential studies based on quantum dot imaging of phago- kinetic tracks显示文摘	Parak W J Boudreau R Gros ML	2002	Adv Mater2002，14，12：	1
18	Rapid vascular effects of steroids - a question of balance?显示文摘	Feldman RD Gros R	2010	Canadian Journal of Cardiology2010，，26：	1
19	Preoperative nutritional evaluation of elderly patients:the Mini Nutritional Assessment as a practical tool显示文摘	Cohendy R Gros T Arnaud-Battandier F	1999	Clin Nutr1999，18，6：	1
20	Conditional and targeted overexpression of vascular chymase causes hypertension in transgenic mice显示文摘	Ju H Gros R You X	2001	Proc Natl Acad Sci USA2001，98，13：	1

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