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| 1 | Prospective randomized controlled trial evaluating cap-assisted colonoscopy vs standard colonoscopy显示文摘AIM: To study the significance of cap-fitted colonoscopy in improving cecal intubation time and polyp detection rate. METHODS: This study was a prospective randomized controlled trial conducted from March 2008 to February 2009 in a tertiary referral hospital at Sydney. The primary end point was cecal intubation time and the secondary endpoint was polyp detection rate. Consecutive cases of total colonoscopy over a 1-year period were recruited. Randomization into either standard colonoscopy (SC) or cap-assisted colonoscopy (CAC) was performed after consent was obtained. For cases randomized to CAC, one of the three sizes of cap was used: D-201-15004 (with a diameter of 15.3 mm), D-201-14304 (14.6 mm) and D-201-12704 (13.0 mm). All of these caps were produced by Olympus Medical Systems, Japan. Independent predictors for faster cecal time and better polyp detection rate were also determined from this study. RESULTS: There were 200 cases in each group. There was no signif icant difference in terms of demographic characteristics between the two groups. CAC, when compared to the SC group, had no signif icant difference in terms of cecal intubation rate (96.0% vs 97.0%, P = 0.40) and time (9.94 ± 7.05 min vs 10.34 ± 6.82 min, P = 0.21), or polyp detection rate (32.8% vs 31.3%, P = 0.75). On the subgroup analysis, there was no significant difference in terms of cecal intubation time by trainees (88.1% vs 84.8%, P = 0.40), ileal intubation rate (82.5% vs 79.0%, P = 0.38) or total colonoscopy time (23.24 ± 13.95 min vs 22.56 ± 9.94 min, P = 0.88). On multivariate analysis, the independent determinants of faster cecal time were consultant-performed procedures (P < 0.001), male patients (P < 0.001), non-usage of hyoscine (P < 0.001) and better bowel preparation (P = 0.01). The determinants of better polyp detection rate were older age (P < 0.001), no history of previous abdominal surgery (P = 0.04), patients not having esophagogastroduodenoscopy in the same setting (P = 0.003), trainee-performed procedures (P = 0.01), usage of hyoscine (P = 0.01) and procedures performed for polyp follow-up (P = 0.01). The limitations of the study were that it was a single-center experience, no blinding was possible, and there were a large number of endoscopists. CONCLUSION: CAC did not signif icantly different from SC in term of cecal intubation time and polyp detection rate. | Hoi-Poh Tee Crispin Corte Hamdan Al-Ghamdi Emilia Prakoso John Darke Raman Chettiar Wassim Rahman Scott Davison Sean P Griffin Warwick S Selby Arthur J Kaffes | 2010 | World Journal of Gastroenterology2010，16，31： | 10 |
| 2 | Operative complications and economic outcomes of cholecystectomy for acute cholecystitis显示文摘BACKGROUND Recent management of acute cholecystitis favors same admission(SA)or emergent cholecystectomy based on overall shorter hospital stay and therefore cost savings.We adopted the practice of SA cholecystectomy for the treatment of acute cholecystitis at our tertiary care center and wanted to evaluate the economic benefit of this practice.We hypothesized that the existence of complications,particularly among patients with a higher degree of disease severity,during SA cholecystectomy could negate the cost savings.AIM To compare complication rates and hospital costs between SA vs delayed cholecystectomy among patients admitted emergently for acute cholecystitis.METHODS Under an IRB-approved protocol,complications and charges for were obtained for SA,later after conservative management(Delayed),or elective cholecystectomies over an 8.5-year period.Patients were identified using the acute care surgery registry and billing database.Data was retrieved via EMR,operative logs,and Revenue Cycle Operations.The severity of acute cholecystitis was graded according to the Tokyo Guidelines.TG18 categorizes acute cholecystitis by Grades 1,2,and 3 representing mild,moderate,and severe,respectively.Comparisons were analyzed withχ2,Fisher’s exact test,ANOVA,ttests,and logistic regression;significance was set at P<0.05.RESULTS Four hundred eighty-six(87.7%)underwent a SA while 68 patients(12.3%)received Delayed cholecystectomy.Complication rates were increased after SA compared to Delayed cholecystectomy(18.5%vs 4.4%,P=0.004).The complication rates of patients undergoing delayed cholecystectomy was similar to the rate for elective cholecystectomy(7.4%,P=0.35).Mortality rates were 0.6%vs 0%for SA vs Delayed.Patients with moderate disease(Tokyo 2)suffered more complications among SA while none who were delayed experienced a complication(16.1%vs 0.0%,P<0.001).Total hospital charges for SA cholecystectomy were increased compared to a Delayed approach($44500±$59000 vs$35300±$16700,P=0.019).The relative risk of developing a complication was 4.2x[95%confidence interval(CI):1.4-12.9]in the SA vs Delayed groups.Among eight patients(95%CI:5.0-12.3)with acute cholecystitis undergoing SA cholecystectomy,one patient will suffer a complication.CONCLUSION Patients with Tokyo Grade 2 acute cholecystitis had more complications and increased hospital charges when undergoing SA cholecystectomy.This data supports a selective approach to SA cholecystectomy for acute cholecystitis. | Christopher P Rice Krishnamurthy B Vaishnavi Celia Chao Daniel Jupiter August B Schaeffer Whitney R Jenson Lance W Griffin William J Mileski | 2019 | World Journal of Gastroenterology2019，25，48： | 8 |
| 3 | Path planning for a mobile robot显示文摘 | Alexopoulos C Griffin P M | 1992 | IEEE Transactions on systems Man and Cybernetics1992，22，2： | 1 |
| 4 | A reduced-order model for evaluating the effect of rotational speed on the natural frequencies and modes shapes of blades显示文摘 | Marugbandhu P Griffin J H | 2003 | Transactions of the ASME2003，125，： | 1 |
| 5 | Identification of der (1; 19) (q10; p10) in five oligodendrogliomas suggests mechanism of concurrent lp and 19q loss显示文摘 | Griffin C A Burger P Morsberger L | 2006 | J Neuropathol Exp Neurol2006，65，10： | 1 |
| 6 | Three-dimensional imaging system显示文摘 | Yee S R Griffin P M | 1994 | Opt Eng1994，33，6： | 1 |
| 7 | Peptide mass maps: a highly informative approach to protein identification 显示文摘 | YATES J R SPEICHER S GRIFFIN P R | 1993 | Anal Biochem1993，214，2： | 1 |
| 8 | Non-chondritic distribution of the highly siderophile elements in mantle sulfides显示文摘 | Alard O Griffin W L Lorand J P | 2000 | Nature2000，，407： | 1 |
| 9 | The impact of organizational climate on safety climate and individual behavior显示文摘 | Neal A Griffin M A Hart P M | 2000 | Safety Science2000，34，13： | 1 |
| 10 | On-chip interconnection architecture of the tile processor显示文摘 | Wentzlaff D Griffin P Hoffmann H | | 0，，05： | 1 |
| 11 | Muhistate outbreak of listeriosis linked to turkey dell meat and subsequent changes in US regulatory policy 显示文摘 | GOTTLIEB S L NEWBERN E C GRIFFIN P M | 2006 | Clin Infect Dis2006，42，1： | 1 |
| 12 | Supplier-and buyer-driven channels in a two-stage supply chain显示文摘 | Ertek G Griffin P M | 2003 | IIE Transactions2003，34，： | 1 |
| 13 | Safety and efficacy of the extended iliofemoral approach in the treatment of complex fractures of the acetabulum显示文摘 | Griffin D B Beaule P E Matta J M | 2008 | J Bone Joint Surg Br2008，87，10： | 1 |
| 14 | Widespread Archean basement beneath the Yangtze eraton 显示文摘 | ZHENG J P GRIFFIN W L O' REILLY S Y | 2006 | Geology2006，7，： | 1 |
| 15 | Coordinatd supply chain management显示文摘 | THOMAS D GRIFFIN P | 1996 | European Journal of Operational Research1996，，94： | 1 |
| 16 | Comparative Life- cycleAir Emissions of Coal,Domestic Natural Gas,LNG,and SNG forElectricity Generation 显示文摘 | Jaramillo P Griffin W M Matthews H S | 2007 | Environmental Science & Technology2007，41，17： | 1 |
| 17 | Human nutrition, the gut microbiome and the immune system显示文摘 | KAU A L AHEM P P GRIFFIN N W | 2011 | Nature2011，474，7351： | 1 |
| 18 | Competitive transport of reducing sugars through a lipophilic membrane facilitated by aryl boron acids显示文摘 | Karpa M J Duggan P J Griffin G J | 1997 | Tetrahedron1997，53，10： | 1 |
| 19 | Predictors of hemolytic uremic syndrome in children during a large outbreak of Escherichia coli O157 infections显示文摘 | Bell BP Griffin PM Eozano P | 1997 | Pediatrics1997，100，1： | 1 |
| 20 | Implications of near-term coal power plant retirement for SO2 and NO: and life cycle GHG emissions显示文摘 | Venkatesh A Jaramillo P Griffin W M | 2012 | Environ Sci Techn2012，46，18： | 1 |
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