|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | The role of the androgen receptor in prostate development and benign prostatic hyperplasia:A review显示文摘Benign prostatic hyperplasia(BPH)is a benign enlargement of the prostate in which incidence increases linearly with age,beginning at about 50 years old.BPH is a significant source of morbidity in aging men by causing lower urinary tract symptoms and acute urinary retention.Unfortunately,the etiology of BPH incidence and progression is not clear.This review highlights the role of the androgen receptor(AR)in prostate development and the evidence for its involvement in BPH.The AR is essential for normal prostate development,and individuals with defective AR signaling,such as after castration,do not experience prostate enlargement with age.Furthermore,decreasing dihydrotestosterone availability through therapeutic targeting with 5a-reductase inhibitors diminishes AR activity and results in reduced prostate size and symptoms in some BPH patients.While there is some evidence that AR expression is elevated in certain cellular compartments,how exactly AR is involved in BPH progression has yet to be elucidated.It is possible that AR signaling within stromal cells alters intercellular signaling and a“reawakening”of the embryonic mesenchyme,loss of epithelial AR leads to changes in paracrine signaling interactions,and/or chronic inflammation aids in stromal or epithelial proliferation evident in BPH.Unfortunately,a subset of patients fails to respond to current medical approaches,forcing surgical treatment even though age or associated co-morbidities make surgery less attractive.Fundamentally,new therapeutic approaches to treat BPH are not currently forthcoming,so a more complete molecular understanding of BPH etiology is necessary to identify new treatment options. | Renee E.Vickman Omar E.Franco Daniel C.Moline Donald J.Vander Griend Praveen Thumbikat Simon W.Hayward | 2020 | Asian Journal of Urology2020，7，3： | 11 |
| 2 | Fracture of the ankle and distal part of the tabia 显示文摘 | Griend R Michelson JD Bone LB | 1996 | Bone JointSurg (AM)1996，78，： | 1 |
| 3 | Methionine loading test is necessary for detection d hyperhomocysteinemia显示文摘 | Van-der Griend R Hass FJ Dunm M | 1998 | J Lab Clin Med1998，132，： | 1 |
| 4 | Optimization of culture conditions for activation and large-scale expansion of human T lymphocytes for biospeciilc antibody-directed cellular immunotherapy 显示文摘 | Lamers CH Van DE Griend RJ Braakman E | 1992 | Cancer1992，51，2： | 1 |
| 5 | Evaluation of ankle instability using the biodex stability systems显示文摘 | Testerman C Griend RV | | 0，，： | 1 |
| 6 | Instructional course lectures,the American Academy of Orthopaedic Surgeons--fractures of the ankle and distal part of the tibia显示文摘 | Griend RV Michelson JD Bone LB | | 0，，11： | 1 |
| 7 | On the Relationship between Thermal Emissivity and the Normalized Difference Vegetation Index for Natural Surfaces显示文摘 | VAN DE GRIEND A A OWE M | 1993 | International Journal of Remote Sensing1993，14，6： | 1 |
| 8 | Methionine loading test is necessary for detection of hyperhomocysteinemia 显示文摘 | Van Der Griend R Hass FJ Duran M etal | 1998 | J Lab Clin Med1998，132，1： | 1 |
| 9 | On the relationship between thermody- namic surface temperature and high-frequency (37 GHz) vertically polarized brightness temperature under semi-arid conditions 显示文摘 | Owe M Van De Griend A | 2001 | International Journal of Remote Sensing2001，22，17： | 1 |
| 10 | Microwave vegetation optical depth and inverse modelling of soil emissivity using Nimbus/ SMMR satellite observations 显示文摘 | Van de Griend A A Owe M | 1994 | Meteorology and Atmos pherie Physics1994，54，： | 1 |
| 11 | NOPEX-A northern hemisphere climate processes land surface experiment显示文摘 | Halldin S Gottsehalk L Griend van de | 1998 | Journal of Hydrology1998，212，1： | 1 |
| 12 | Methionine loading test is necessary for detection of hyperhomocysteinemia 显示文摘 | Van Der Griend R Hass FJ Duran M | 1998 | J Lab Clin Med1998，132，1： | 1 |
| 13 | The treatment of giant-cell tumors of the distal part of the radius显示文摘 | Vander Griend RA and Funderburk CH | 1993 | J Bone Joint Surg (Am)1993，75，6： | 1 |
| 14 | On the relationship between thermal emissivity and the normalized difference vegetation index for natural surfaces 显示文摘 | van de GRIEND A A OWE M | 1993 | International Journal of Remote Sensing1993，14，6： | 1 |
| 15 | Open reduction and internalfixation of vertical shear pelvic fractures显示文摘 | Ward EF Tomasin J Vander Griend RA | 1987 | J Trauma1987，27，3： | 1 |
| 16 | Open reduction and internal fixation of vertical shear pelvic fractures显示文摘 | Ward E Tomasin J Vander Griend R | 1987 | J Traurna1987，27，： | 1 |
| 17 | On the relationship between thermal emissivity and the normalized difference vegetation index for natural surfaces显示文摘 | Van de Griend A A Owe M | | 0，，06： | 1 |
| 18 | The pluripotency factor Nanog is directly upregulated by the androgen receptor in prostate caneercells显示文摘 | Kregel S Szmulewitz RZ Vander Griend DJ | 2014 | Prostate2014，74，15： | 1 |
| 19 | On the relationship between thermal emissivity and the normalized difference vegetation index for natural surfaces显示文摘 | Van De Griend A A Owe M | 1993 | Int J Remote Sens1993，14，6： | 1 |
| 20 | Bare soil surface resistance to evaporation by vapor diffusion under semiarid conditions显示文摘 | VAN DE GRIEND A A OWE M | | 0，，02： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员