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| 1 | 限制热量摄入6个月对超重者寿命指标、代谢调节及氧化应激的影响——随机对照试验AuthorAffiliations:PenningtonBiomedicalResearchCenter.LouisianaStateUniversity.BatonRouge;andGarvan.InstituteforMedicalResearch.Dadinghurst,AustraIia(DrHeilbronn).显示文摘背景:长期限制热量摄入可延长啮齿类动物的寿命。但是,尚未有研究观测长期限制人体热量是否会影响其寿命及氧化应激指标,降低代谢率。
目的:在超重但不肥胖(体重指数为25—30)的人群中研究限制热量6个月伴/不伴运动对其产生的影响。
设计、地点及参试者:于2002年3月至2004年8月在位于路易斯安娜州首府巴顿鲁治的研究中心对48名不好动的健康人进行随机对照研究。
干预:参试者在6个月内随机分为4个组:对照组(饮食可维持体重);限制热量组(限制基线所需能量的25%);限制热量+运动组(限制12.5%的热量+运动增加12.5%的能耗);极低热量饮食组(每日摄入890keal,直至体重减少15%,随后采用维持体重的饮食)。
主要观测指标:机体组成;硫酸脱氢表雄酮(dehydroepiandrostemne sulfate,DHEAS)、葡萄糖及胰岛素水平;蛋白羰基化合物;DNA损伤;24小时能耗;核心体温。
结果:6个月时各组体重变化的均值(标准误)为:对照组-1.0%(1.1%);限制热量组-10.4%(0.9%);限制热量+运动组-10.0%(0.8%);极低热量饮食组-13.9%(0.7%)。6个月时,各干预组空腹血糖水平较基线明显降低(P均〈0.01),而DHEAS和葡萄糖水平没有改变。限制热量组及限制热量+运动组核心体温有所下降(P均〈0.05)。对机体组成进行校正后发现,对照组24小时静息能耗无变化,但限制热量组(-135kcal/d[42kcal/d])、限制热量+运动组(-117kcal/d[52kcal/d])和极低热量饮食组(-125kcal/d[35kcal/d])24小时静息能耗有所下降(P均〈0.008)。上述“代谢调节”(超出预计值的-6%)与对照组相比存在显著差异(P〈0.05)。6个月时,各组蛋白羰基化合物的浓度较基线时无变化,而各干预组DNA损伤有所减少(P〈0.005)。
结论:我们的研究结果显示,长期限制热量可降低人类寿命的2种指标(即空腹胰岛素水平和体温)。此外,我们的研究结果还支持下述理论,即限制热量能降低代谢率,且超过缩小代谢面积产生的相应效应。我们尚需开展远期研究来评价限制热量能否延缓人类衰老过程。 | Leonie K. Heibronn Lilian de Jonge Madlyn I. Frisard James P. DeLany D. Enette Larson-Meyer Jennifer Rood Tuong Nguyen Corby K. Martin Julia Volaufova Marlene M. Most Frank L. Greenway Steven R. Smith Walter A. Deutsch Donald A. Williamson Eric Ravussin 顾佳(译) | 2006 | 美国医学会杂志(中文版)2006，25，5： | 18 |
| 2 | Current methods for the maturation of induced pluripotent stem cellderived cardiomyocytes显示文摘Induced pluripotent stem cells(iPSCs) were first generated by Yamanaka and colleagues over a decade ago. Since then, iPSCs have been successfully differentiated into many distinct cell types, enabling tissue-, disease-, and patientspecific in vitro modelling. Cardiovascular disease is the greatest cause of mortality worldwide but encompasses rarer disorders of conduction and myocardial function for which a cellular model of study is ideal. Although methods to differentiate iPSCs into beating cardiomyocytes(iPSC-CMs) have recently been adequately optimized and commercialized, the resulting cells remain largely immature with regards to their structure and function,demonstrating fetal gene expression, disorganized morphology, reliance on predominantly glycolytic metabolism and contractile characteristics that differ from those of adult cardiomyocytes. As such, disease modelling using iPSC-CMs may be inaccurate and of limited utility. However, this limitation is widely recognized, and numerous groups have made substantial progress in addressing this problem. This review highlights successful methods that have been developed for the maturation of human iPSC-CMs using small molecules,environmental manipulation and 3-dimensional(3 D) growth approaches. | Pranav Machiraju Steven C Greenway | 2019 | World Journal of Stem Cells2019，11，1： | 7 |
| 3 | Mechanisms of Salt Tolerance in Nonhalophytes显示文摘 | H Greenway R Munns | 1980 | Annual Review of Plant Physiology1980，，： | 3 |
| 4 | Development and implementation of a NURBS curve motion interpolator显示文摘 | ZHANG Q G GREENWAY R B | 1998 | Robotics and Computer-Integrated Manufacturing1998，14，1： | 1 |
| 5 | Mechanism of tolerance in nonhalophytes Ann显示文摘 | GREENWAY H | 1980 | Rev Plant Physiol1980，31，： | 1 |
| 6 | Nutrient content of wetland plants in constructed wetlands receiving municipal effluent in tropical Australia显示文摘 | Greenway M | 1997 | Water Sci Technol1997，35，5： | 1 |
| 7 | Prehypertension in disease-free adults:a marker for an adverse cardiometabolic risk profile显示文摘 | Gupta AK McGlone M Greenway FL | 2010 | Hypertens Res2010，33，9： | 1 |
| 8 | Proton exchange membrane(PEM)electrolyzer operation under anode liquid and cathode vapor feed configurations显示文摘 | GREENWAY S D FOX E B EKECHUKWU A A | 2009 | International Journal of Hydrogen Energy2009，34，16： | 1 |
| 9 | Effect of naltrexone plus bupropion on weight loss in overweight and obese adults (COR-I):a multicentre,randomised,double-blind,placebo-controlled,phase 3 trial显示文摘 | Greenway FL Fujioka K Plodkowski RA | | 0，，： | 1 |
| 10 | HIV-1 Nef:a critical factor in viral-induced pathogenesis显示文摘 | Greenway A L Holloway G McPhee D A | 2000 | Adv Pharmacol2000，48，： | 1 |
| 11 | The impact of chan- nel path length on PEMFC flow-field design显示文摘 | SHIMPALEE S GREENWAY S ZEE J W V | 2006 | Journal of Power Sources2006，160，： | 1 |
| 12 | Milner: Country-specific Factors and the Pattern of Horizontal and Vertical Trade in the UK 显示文摘 | Greenway David R C Hine C | 1994 | Weltwirtschaftlicbes Archly1994，130，1： | 1 |
| 13 | Analyst显示文摘 | Greenway GM Kometa N | 1994 | 119 ( 5 ) : 9291994，119，5： | 1 |
| 14 | Cotton messenger RNA sequences exist in both polyadenylated and nonpolyadenylated forms显示文摘 | GALAU G A LEGOCKI A B GREENWAY S C | 1981 | Biol Chem1981，256，5： | 1 |
| 15 | Developmental Biochemistry of Cottonseed Embryogenesis and Germination Changing Messenger Ribonucleic Acid Populations as Shown by in Vitro and in Vivo Protein-Synthesis 显示文摘 | DURE L GREENWAY S C GALAU G A | | Biochemis- try0，20，4： | 1 |
| 16 | Mechanisms of salt tolerance in nonhalophytes 显示文摘 | GREENWAY H MUNNS R | 1980 | AnnualReview of Plant Physiology1980，31，： | 1 |
| 17 | Mechanisms of salt tolerance in non-halophytes显示文摘 | Greenway H Munne R | 1980 | Annual Review of Plant Physiology1980，31，： | 1 |
| 18 | Predicting Water and Current Distributions in a Commercial-Size PEMFC 显示文摘 | Shimpalee S Greenway S Spuckler D | 2004 | Journal of Power Sources2004，135，12： | 1 |
| 19 | Suitability of macrophytes for nutrient removal from surface flow constructed wetlands receiving secondary treated sewage effluent in Queensland, Australia显示文摘 | GREENWAY M | 2003 | Wat Sci Tech2003，48，2： | 1 |
| 20 | Development and implementa- tion of a NURBS curve motion interpolator 显示文摘 | ZHANG Q G GREENWAY B | 1998 | Robotics and Computer-Integrated Manufacturing1998，14，1： | 1 |
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