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| 1 | Role of MMP-2 and MMP-9 and their natural inhibitors in liver fibrosis, chronic pancreatitis and non-specific inflammatory bowel diseases显示文摘BACKGROUND: There is a growing evidence that matrix metalloproteinase (MMP)-2 and MMP-9 (gelatinases) play an important role in the pathogenesis of numerous disorders especially with inflammatory etiology and extracellular matrix (ECM) remodeling. Despite the fact that gelatinases involve in liver cirrhosis is provided in the literature, their role in the pathogenesis of chronic pancreatitis and non-specific inflammatory bowel diseases is still under investigation.DATA SOURCES: We carried out a PubM ed search of English language articles relevant to the involvement of gelatinases in the pathogenesis of liver fibrosis, pancreatitis, and non-specific inflammatory bowel diseases.RESULTS: The decreased activity of gelatinases, especially MMP-2, is related to the development of liver fibrosis, probably due to the decrease of capability for ECM remodeling. Similar situation can be found in chronic pancreatitis; however reports on this matter are rare. The presence of non-specific inflammatory bowel diseases results in MMP-9 activity elevation.CONCLUSION: The fluctuation of gelatinases activity during liver fibrosis, chronic pancreatitis and non-specific inflammatorybowel diseases is observed, but the exact role of these enzymes demands further studies. | Jacek Kurzepa Agnieszka M?dro Gra?yna Czechowska Joanna Kurzepa Krzysztof Celiński Weronika Kazmierak Maria S?omka | 2014 | Hepatobiliary & Pancreatic Diseases International2014，13，6： | 15 |
| 2 | UVA-induced decerease ill nuclear factor-kappaB activity in human keratinocytes显示文摘 | Djavaheri-Mergny M Gras MP Mergny JL | 1999 | Biochem J1999，338，3： | 1 |
| 3 | Life Prediction for HLW Containers-issues Re- lated to Long-teml Extrapolation of Corrosion Resestance 显示文摘 | Gras J M | 2002 | Comptes Rendus Physique2002，3，： | 1 |
| 4 | The response of some vegetables to vacuum impregnation 显示文摘 | Gras M Vidal-Brotonl D Betoret N | 2002 | Innovative Food Science & Emerging Technology2002，3，3： | 1 |
| 5 | Implantation of cardiac resynchronization therapy systems in the CARE-HF trial: procedural success rate and safety 显示文摘 | Gras D Bocker D Lunati M | 2007 | Europace2007，9，7： | 1 |
| 6 | Vacuum impregnation and osmotic dehydration in matrix engineering:Application in functional fresh food development显示文摘 | Chiralt A Betoret N Gras M | 2001 | Journal of Food Engineering2001，8，49： | 1 |
| 7 | Implantation of cardiac resynchronization therapy systems in the care-HF trial : procedural success rate and safety 显示文摘 | Gras D Bocker D Lunati M | 2007 | Europace2007，9，7： | 1 |
| 8 | Vascularized bone graft pedicled on the volar carpal artery from the volar distal radius as primary procedure for scaphoid non - union 显示文摘 | Gras M Mathoulin C | 2011 | Orthop Traumatol Surg Res2011，97，8： | 1 |
| 9 | Entrepre- neurial processes in social contexts: How are they dif- ferent, if at all?显示文摘 | Lumpkin G T Moss T W Gras D M | 2013 | Small Business Economics2013，40，3： | 1 |
| 10 | Choristoma of visual organ in children显示文摘 | Niwald A Orawiec B Graek M | | 0，，7： | 1 |
| 11 | A randomized trial of treatment for multisystem Langerhans cell histocytosis显示文摘 | Gadner H Gras N Arico M | 2001 | J Pediatr2001，138，5： | 1 |
| 12 | Expression and activity a recombinant chimeric protein composed of pokeweed antiviral protein and of human interleukin-2 显示文摘 | DORE J M GRAS E WIJDENES J | 1997 | FEBS Letters1997，402，： | 1 |
| 13 | Dopamine effects on pulmo- nary artery pressure in hypotensive preterm infants with patent ductus ar- teriosus 显示文摘 | Liet M Boscher C Gras - Leguen C | 2002 | J Pediatr2002，140，3： | 1 |
| 14 | An empirical approach to the organizational determinants of spin- off creation in European universities 显示文摘 | Gras J M G Lapera D R G Solves I M | 2008 | International Entrepreneurship and Management Journal2008，4，2： | 1 |
| 15 | An experimental model for mixed friction during running - in 显示文摘 | Nogueira I Dias A M Gras R | 2002 | Wear2002，253，： | 1 |
| 16 | A bistatic SAR mission for earth observation on based of a small satellite显示文摘 | D'ERRICO M GRAS M VETRELLA S | 1996 | Acta Astronautica1996，39，912： | 1 |
| 17 | Contribution of the Chemical Structure of wheat starch to Japanese noodle quality显示文摘 | Batey I L Gras P W Curtin B M | 1997 | Journal of the Science of Food and Agriculture1997，74，： | 1 |
| 18 | The vesicular glutamate transporter VGLUT3 synergizes striatal acetylcholine tone 显示文摘 | Gras C Amilhon B Lepieard E M | 2008 | Nat Neurosci2008，11，3： | 1 |
| 19 | A low-cost high efficiency solar cell based on dye-sensitized colloidal TiO2 films 显示文摘 | O' REGAN B GRA TZEL M | 1991 | Nattwe1991，353，6346： | 1 |
| 20 | Effect of dietary formats on growth performance, carcass traits, sensory quality,intestinal microflora, and stomach al- terations in growing-firfishing pigs显示文摘 | Overland M Gra~ali T Kjos N P et a/ | 2000 | J Anita Sci2000，78，18： | 1 |
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