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| 1 | Management of gastroesophageal reflux disease: Patient and physician communication challenges and shared decision making显示文摘Gastroesophageal reflux disease(GERD) is a common upper esophageal condition and typical symptoms can include heartburn and sensation of regurgitation while atypical symptoms include chronic cough, asthma, hoarseness, dyspepsia and nausea. Typically, diag-nosis is presumptive given the presence of typical and atypical symptoms and is an indication for empiric therapy. Treatment management can include lifestyle modifications and/or medication therapy with proton pump inhibitor(PPI) class being the preferred and most effective. Complete symptom resolution is not always achieved and long-term PPI therapy can put patients at risk for serious side effects and needless expense. The brain-gut connection and hypervigilance plays an important role in symptom resolution and treatment success, especially in the case of non-PPI responders. Hypervigilance is a combination of increased esophageal sensory sensitivity in combination with exaggerated threat perception surrounding esophageal symptoms. Hypervigilance requires a different approach to GERD managements, where continued PPI therapy and surgery are usually not recommended. Rather, helping physicians and patients understand the brain-gut connection can guide and improve care.Education and reassurance should be the main pillars or treatment. However, it is important not to suggest the symptoms are due to anxiety alone, this often leads to patient dissatisfaction. Patient dissatisfaction with treatment reveals the need for a more patient-centered approach to GERD management and better communication between patients and providers. Shared decision making(SDM) with the incorporation of patient-reported outcomes(PRO) promotes patient adherence and satisfaction. SDM is a joint discussion between clinician and patient in which a mutually shared solution is explored for GERD symptoms. For SDM to work the physician needs to capture patients' perceptions which may not be obtained in the standard interview. This can be done through the use of PROs which promote a dialogue with patients about their symptoms and treatment priorities in the context of the SDM patient encounter. SDM could potentially help in the management of patient expectations for GERD treatment, ultimately positively impacting their health-related quality of life. | Scott Klenzak Igor Danelisen Grace D Brannan Melissa A Holland Miranda AL van Tilburg | 2018 | World Journal of Clinical Cases2018，6，15： | 10 |
| 2 | Weight gain following breast cancer diagnosis: Implication and proposed mechanisms显示文摘Weight gain occurs in the majority of women following breast cancer treatment. An overview of studies describing weight gain amongst women treated with early to modern chemotherapy regimens is included. Populations at higher risk include women who are younger, closer to ideal body weight and who have been treated with chemotherapy. Weight gain ranges between 1 to 5 kg, and may be associated with change in body composition with gain in fat mass and loss in lean body mass. Women are unlikely to return to pre-diagnosis weight. Possible mechanisms including inactivity and metabolic changes are explored. Potential interventions are reviewed including exercise, dietary changes andpharmacologic agents. Although breast cancer prognosis does not appear to be significantly impacted, weight gain has negative consequences on quality of life and overall health. Future studies should explore change in body composition, metabolism and insulin resistance. Avoiding weight gain in breast cancer survivors following initial diagnosis and treatment should be encouraged. | Grace Makari-Judson Barry Braun D Joseph Jerry Wilson C Mertens | 2014 | World Journal of Clinical Oncology2014，5，3： | 8 |
| 3 | Dextran sulfate sodium-induced acute colitis impairs dermal lymphatic function in mice显示文摘AIM: To investigate whether dermal lymphatic function and architecture are systemically altered in dextran sulfate sodium(DSS)-induced acute colitis.METHODS: Balb/c mice were administered 4% DSS in lieu of drinking water ad libitum for 7 d and monitored to assess disease activity including body weight, diarrhea severity, and fecal bleeding. Control mice received standard drinking water with no DSS. Changes in mesenteric lymphatics were assessed following oral administration of a fluorescently-labelled fatty acid analogue, while dermal lymphatic function and architecture was longitudinally characterized using dynamic near-infrared fluorescence(NIRF) imaging following intradermal injection of indocyanine green(ICG) at the base of the tail or to the dorsal aspect of the left paw prior to, 4, and 7 d after DSSadministration. We also measured dye clearance rate after injection of Alexa680-bovine serum albumin(BSA). NIRF imaging data was analyzed to reveal lymphatic contractile activity after selecting fixed regions of interest(ROIs) of the same size in fluorescent lymphatic vessels on fluorescence images. The averaged fluorescence intensity within the ROI of each fluorescence image was plotted as a function of imaging time and the lymphatic contraction frequency was computed by assessing the number of fluorescent pulses arriving at a ROI. RESULTS: Mice treated with DSS developed acute inflammation with clinical symptoms of loss of body weight, loose feces/watery diarrhea, and fecal blood, all of which were aggravated as disease progressed to 7 d. Histological examination of colons of DSS-treated mice confirmed acute inflammation, characterized by segmental to complete loss of colonic mucosa with an associated chronic inflammatory cell infiltrate that extended into the deeper layers of the wall of the colon, compared to control mice. In situ intravital imaging revealed that mice with acute colitis showed significantly fewer fluorescent mesenteric lymphatic vessels, indicating impaired uptake of a lipid tracer within mesenteric lymphatics. Our in vivo NIRF imaging data demonstrated dilated dermal lymphatic vessels, which were confirmed by immunohistochemical staining of lymphatic vessels, and significantly reduced lymphatic contractile function in the skin of mice with DSS-induced acute colitis. Quantification of the fluorescent intensity remaining in the depot as a function of time showed that there was significantly higher Alexa680-BSA fluorescence in mice with DSSinduced acute colitis compared to pre-treatment with DSS, indicative of impaired lymphatic drainage.CONCLUSION: The lymphatics are locally and systemically altered in acute colitis, and functional NIRF imaging is useful for noninvasively monitoring systemic lymphatic changes during inflammation. | Germaine D Agollah Grace Wu Ho-Lan Peng Sunkuk Kwon | 2015 | World Journal of Gastroenterology2015，21，45： | 2 |
| 4 | Characteristics of gas-solids fluidizad beds in different flow regimes显示文摘 | Bai D Issangya Y S Grace J R | 1999 | Industrial Engineering Chemistry Research1999，38，： | 1 |
| 5 | Zoonosis emergence linked to agricultural intensification and environmental change显示文摘 | Jones BA Grace D Kock R | 2013 | Proc Nat Acad Sci USA2013，110，21： | 1 |
| 6 | Assessment of lead, cadmium, and zinc contamination of roadside soils, surface films, and vegetables in Kampala City, Uganda 显示文摘 | Grace N Hannington O Miriam D | 2006 | Environmental Research2006，101，1： | 1 |
| 7 | Influence of nitrogen fertiliser application and timing on greenhouse gas emissions from a lychee (Litchi chinensis)orchard in humid subtropical Australia显示文摘 | Rowlings D W Grace P R Scheer C et d | 2013 | Agr Ecosyst Environ2013，179，1： | 1 |
| 8 | Broadband Communications from a High-altitude Platform:the European HeliNet Programme显示文摘 | Thornton J Grace D Spillard C | 2001 | Electronics & Communication Engineering Journal2001，6，： | 1 |
| 9 | Oscillation criteria for certain nth order differential equations with deviating arguments显示文摘 | Agarwal R P Grace S R O'regan D | 2001 | J Math Anal Appl2001，262，： | 1 |
| 10 | High Altitude Platforms for Wireless Communications显示文摘 | TOZER T C GRACE D | 2001 | Electronics & Communication Engineering Journal2001，13，3： | 1 |
| 11 | Cardiovascular changes with laryngeal mask airway in cardiac anaesthesia显示文摘 | Bennett SR Grace D Griffin SC | 2004 | British Journal of Anaesthesia2004，92，6： | 1 |
| 12 | Effects of hydrogel/ silver coatings on in vitro adhesion to catheters of bacteria associated with urinary tract infection显示文摘 | AHEAM D G GRACE D T JENNINGS M J | 2000 | Curr Microbiol2000，41，2： | 1 |
| 13 | Pharmacologic therapy of portal hypertension显示文摘 | Minor M A Grace N D | 2006 | Clin Liver Dis2006，10，3： | 1 |
| 14 | High-altitude platforms for wireless commu- nications显示文摘 | TOZER T C GRACE D | 2001 | Electronic & Communications Engineering Journal2001，13，3： | 1 |
| 15 | Oscillation criteria for certain n th order differential equations with deviating arguments显示文摘 | Agarwal R P Grace S R O Regan D | 2001 | J Math Anal Appl2001，262，： | 1 |
| 16 | Technical Risks and Mitigation Measures in Combustion Turbine Project Development显示文摘 | | 2003 | Transactions of the ASME2003，125，1： | 1 |
| 17 | Chaotic behavior of fluidized beds based on pressureand voidage fluctuations 显示文摘 | Bi H T Grace J R | 1997 | AIChE J1997，43，5： | 1 |
| 18 | Optimizing an Array of Antennas for Cellular Coverage from High Altitude Platform显示文摘 | Thornton J Grace D Capstick M H | 2003 | IEEE Transactions on Wireless Communications2003，2，3： | 1 |
| 19 | Broadband Communications from High Altitude Platform:The Euroupean Heli Net Program显示文摘 | THORNTON J GRACE D | 2001 | Electron Commun Mag J2001，13，3： | 1 |
| 20 | Biomass gasification in a circulating fluidized bed 显示文摘 | X T LI J R GRACE C J LIM et d | 2004 | Biomass and Bioenergy2004，28，3： | 1 |
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