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| 1 | Antiherpetic activity of a sulfated polysaccharide from Agaricus brasiliensis mycelia显示文摘 | Francielle Tramontini Gomes de Sousa Cardozo Carla Maísa Camelini Alessandra Mascarello Márcio José Rossi Ricardo José Nunes Célia Regina Monte Barardi Margarida Matos de Mendon?a Cláudia Maria Oliveira Sim?es | 2011 | Antiviral Research2011，，1： | 2 |
| 2 | Interleukin-6-174G/C polymorphism is associated with a decreased risk of type 2 diabetes in patients with chronic hepatitis C virus显示文摘BACKGROUND Chronic hepatitis C(CHC)is associated with type 2 diabetes mellitus.Although the pathogenesis remains to be elucidated,a growing evidence has suggested a role of pro-inflammatory immune response.Increased serum concentrations of Interleukin 6(IL-6)have been associated with insulin resistance,type 2 diabetes mellitus as well as advanced forms of liver disease in chronic hepatitis C infection.AIM To investigate the frequency of IL-6-174G/C(rs1800795)single nucleotide polymorphism(SNP)in CHC patients and in healthy subjects of the same ethnicity.Associations between type 2 diabetes mellitus(dependent variable)and demographic,clinical,nutritional,virological and,IL-6 genotyping data were also investigated in CHC patients.METHODS Two hundred and forty-five patients with CHC and 179 healthy control subjects(blood donors)were prospectively included.Type 2 diabetes mellitus was diagnosed according to the criteria of the American Diabetes Association.Clinical,biochemical,histological and radiological methods were used for the diagnosis of the liver disease.IL-6 polymorphism was evaluated by Taqman SNP genotyping assay.The data were analysed by logistic regression models.RESULTS Type 2 diabetes mellitus,blood hypertension and liver cirrhosis were observed in 20.8%(51/245),40.0%(98/245)and 38.4%(94/245)of the patients,respectively.The frequency of the studied IL-6 SNP did not differ between the CHC patients and controls(P=0.81)and all alleles were in Hardy-Weinberg equilibrium(P=0.38).In the multivariate analysis,type 2 diabetes mellitus was inversely associated with GC and CC genotypes of IL-6-174(OR=0.42;95%CI=0.22-0.78;P=0.006)and positively associated with blood hypertension(OR=5.56;95%CI=2.79-11.09;P<0.001).CONCLUSION This study was the first to show that GC and CC genotypes of IL-6-174 SNP are associated with a decreased risk of type 2 diabetes mellitus in patients chronically infected with hepatitis C virus.The identification of potential inflammatory mediators involved in the crosstalk between hepatitis C virus and the axis pancreas-liver remains important issues that deserve further investigations. | Cliviany Borges da Silva Diego Alves Vieira Luisa Freitas de Melo Anna Luiza Soares Chagas Adriana Dias Gomes César Lúcio Lopes de Faria Jr Rosangela Teixeira Dulciene Maria de Magalh?es Queiroz Gifone Aguiar Rocha Maria Marta Sarquis Soares Juliana Maria Trindade Bezerra Luciana Diniz Silva | 2020 | World Journal of Hepatology2020，12，4： | 2 |
| 3 | Vitamin D as supplementary treatment for tuberculosis: a double-blind, randomized, placebo-controlled trial显示文摘 | WEISE C GOMES VF RABNA P | 2009 | Am J Respir Crit Care Med2009，179，9： | 1 |
| 4 | Heavy-tailed phenomena in satisfiability and constraint satisfaction problems显示文摘 | C Gomes B Selman N Crato | 2000 | Journal of Automatic Reasoning2000，24，12： | 1 |
| 5 | Vitamin D as supplementary treatment for tuberculosis : a double - blind, randomized, placebo - controlled trial 显示文摘 | Wejse C Gomes VF Rabna P | 2009 | Am J Respir Crit Care Med2009，179，9： | 1 |
| 6 | Pressure induces folding intermediates that are crucial for protrin-DNA recognition and virus assembly显示文摘 | SILVA J L OLIVEIRA A C GOMES A M | | 0，，1： | 1 |
| 7 | Hardy - Weinberg qualitycontrol 显示文摘 | Gomes I Collins A Lonjou C | 1999 | Annals of Human Genetics1999，63，6： | 1 |
| 8 | Effect of dental surface treatment with Nd:YAG and Er:YAG lasers on bond strength of resin composite to recently bleached enamel显示文摘 | Rocha Gomes Torres C Caneppele TM Del Moral de Lazari R | 2012 | Laser Med Sci2012，27，4： | 1 |
| 9 | Livin, a novel inhibitor of apoptosis protein family member显示文摘 | Kasof G M Gomes B C | 2001 | J Biol Chem2001，276，： | 1 |
| 10 | Microorganisms from canals of root-filled teeth with periapical lesions显示文摘 | PINHEIRO E T GOMES B P FERRAZ C C | 2003 | Int Endod J2003，36，1： | 1 |
| 11 | Influence of combined acid treatment on physico-chemical characteristics of ultrastable zeolite Y and on its catalytic properties in the disproportionation of ethylbenzene 显示文摘 | Leiras Gomes A C | 1997 | Applied Catalysis A: General1997，148，： | 1 |
| 12 | Livin, a novel inhibitor of apoptosis protein family member 显示文摘 | Kasof G M Gomes B C | 2001 | J Biol Chem2001，276，5： | 1 |
| 13 | Reflection Z-scan technique for measurements of optical properties of surface显示文摘 | Petrov D V Gomes A S L de Arauújo C B | | 0，，： | 1 |
| 14 | Combining me- ta-learning and search techniques to select parameters for support vector machines 显示文摘 | Taciana A F Gomes Ricardo B C Prudeneio | 2012 | Neuroeomputing2012，75，1： | 1 |
| 15 | Medley GF (2004) The reinfection threshold promotes variability in tuberculosis epidemiology and vaccine efficacy显示文摘 | Gomes M G Franco A O Gomes M C | 2004 | Proceedings of the Royal Society B Biological Sciences2004，271，： | 1 |
| 16 | Supercritical fluid extraction of lipids from spent coffee grounds显示文摘 | Ricardo M C Joao F Gomes da Silva M D R | 2009 | Journal of Supercritical Fluids2009，51，： | 1 |
| 17 | Selectivity sequence and competitive adsorption of heavy metals by Brazilian soils显示文摘 | Gomes P C Fontes M P F Costa L M | 2001 | Soil Sci Soc Am J2001，65，： | 1 |
| 18 | Tonin in rat heart with experimental hypertrophy显示文摘 | BORGES J C SILVA J A Jr GOMES M A | 2003 | Am J Physiol Heart Circ Physiol2003，284，6： | 1 |
| 19 | Apical ntrusion of debris and irrigants using two hand and three engine-driven instrumentation techniques 显示文摘 | Ferraz C C Gomes N V Gomes B P | 2001 | Int Endod J2001，34，5： | 1 |
| 20 | Livin, a novel inhibitor of apoptosis protein family member显示文摘 | Kasof G M Gomes B C | 2001 | J Biol Chem2001，276，5： | 1 |
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