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| 1 | Passive expansion of sub-maximally dilated transjugular intrahepatic portosystemic shunts and assessment of clinical outcomes显示文摘AIM To assess for passive expansion of sub-maximally dilated transjugular intrahepatic portosystemic shunts(TIPS) and compare outcomes with maximally dilated TIPS.METHODS Polytetrafluoroethylene covered TIPS(Viatorr) from July 2002 to December 2013 were retrospectively reviewed at two hospitals in a single institution. Two hundred and thirty patients had TIPS maximally dilated to 10 mm(m TIPS), while 43 patients who were at increased risk for hepatic encephalopathy(HE), based on clinical evaluation or low pre-TIPS portosystemic gradient(PSG), had 10 mm TIPS sub-maximally dilated to 8 mm(sm TIPS). Group characteristics(age, gender, Model for End-Stage Liver Disease score, post-TIPS PSG and clinical outcomes were compared between groups, including clinical success(ascites or varices), primary patency,primary assisted patency, and severe post-TIPS HE. A subset of fourteen patients with sm TIPS underwent follow-up computed tomography imaging after TIPS creation, and were grouped based on time of imaging(< 6 mo and > 6 mo). Change in diameter and crosssectional area were measured with 3D imaging software to evaluate for passive expansion.RESULTS Patient characteristics were similar between the sm TIPS and m TIPS groups, except for pre-TIPS portosystemic gradient, which was lower in the sm TIPS group(19.4 mm Hg ± 6.8 vs 22.4 mm Hg ± 7.1, P = 0.01). Primary patency and primary assisted patency between sm TIPS and m TIPS was not significantly different(P = 0.64 and 0.55, respectively). Four of the 55 patients(7%) with sm TIPS required TIPS reduction for severe refractory HE, while this occurred in 6 of the 218 patients(3%) with m TIPS(P = 0.12). For the 14 patients with follow-up computed tomography(CT) imaging, the median imaging follow-up was 373 d. There was an increase in median TIPS diameter, median percent diameter change, median area, and median percent area change in patients with CT follow-up greater than 6 mo after TIPS placement compared to follow-up within 6 mo(8.45 mm, 5.58%, 56.04 mm^2, and 11.48%, respectively, P = 0.01).CONCLUSION Passive expansion of sm TIPS does occur but clinical outcomes of sm TIPS and m TIPS were similar. Sub-maximal dilation can prevent complications related to overshunting in select patients. | Michael C Hsu Charles N Weber S William Stavropoulos Timothy W Clark Scott O Trerotola Richard D Shlansky Goldberg Michael C Soulen Gregory J Nadolski | 2017 | World Journal of Hepatology2017，9，12： | 11 |
| 2 | Incident frailty and cognitive impairment by heart failure status in older patients with atrial fibrillation: the SAGE-AF study显示文摘Background Atrial fibrillation(AF) and heart failure(HF) frequently co-occur in older individuals. Among patients with AF, HF increases risks for stroke and death, but the associations between HF and incident cognition and physical impairment remain unknown. We aimed to examine the cross-sectional and prospective associations between HF, cognition, and frailty among older patients with AF. Methods The SAGE-AF(Systematic Assessment of Geriatric Elements in AF) study enrolled 1244 patients with AF(mean age 76 years, 48% women) from five practices in Massachusetts and Georgia. HF at baseline was identified from electronic health records using ICD-9/10 codes. At baseline and 1-year, frailty was assessed by Cardiovascular Health Survey score and cognition was assessed by the Montreal Cognitive Assessment. Results Patients with prevalent HF(n = 463, 37.2%) were older, less likely to be non-Hispanic white, had less education, and had greater cardiovascular comorbidity burden and higher CHA2 DS2 VASC and HAS-BLED scores than patients without HF(all P's < 0.01). In multivariable adjusted regression models, HF(present vs. absent) was associated with both prevalent frailty(adjusted odds ratio [a OR]: 2.38, 95% confidence interval [CI]: 1.64-3.46) and incident frailty at 1 year(a OR: 2.48, 95% CI: 1.37-4.51). HF was also independently associated with baseline cognitive impairment(a OR: 1.60, 95% CI: 1.22-2.11), but not with developing cognitive impairment at 1 year(a OR 1.04, 95%CI: 0.64-1.70). Conclusions Among ambulatory older patients with AF, the co-existence of HF identifies individuals with physical and cognitive impairments who are at higher short-term risk for becoming frail. Preventive strategies to this vulnerable subgroup merit consideration. | Wei-Jia WANG Darleen Lessard Jane Saczynski Robert J Goldberg Alan S.Go Tenes Paul Ely Gracia David D McManus | 2020 | Journal of Geriatric Cardiology2020，17，11： | 2 |
| 3 | Real-Coded Genetic Algorithm 显示文摘 | | 1991 | Virtual Alphabets and Blocking Complex Systems1991，5，： | 1 |
| 4 | Signal Timing Determination Using Genetic Algorithms 显示文摘 | FOY M D BENEKOHAL D E GOLDBERG D E | 1992 | Transportation Research Record1992，1365，： | 1 |
| 5 | Minor elements in sea water 显示文摘 | Goldberg E D | 1965 | Chemical Oceanography1965，，1： | 1 |
| 6 | Genetic and Evolutionary Algorithms Come of Age显示文摘 | D E Goldberg | 1994 | Comm ACE1994，37，3： | 1 |
| 7 | Genome-wide fetal aneuploidy detection by maternal plasma DNA sequencing显示文摘 | Bianchi D W Platt L D Goldberg J D | 2012 | Obstet Gyneeol2012，119，5： | 1 |
| 8 | Pattern and consequences of interspecific competition in natural communities:a review of field experiments with plants显示文摘 | Goldberg D E Barton A M | 1992 | American Naturalist1992，139，： | 1 |
| 9 | A computer model of the secondary arc in single phase operation of transmis- sion lines显示文摘 | Goldberg S Horton W F Tziouvaras D | 1989 | IEEE Trans on Power Delivery1989，4，1： | 1 |
| 10 | Single-mode operation of a coiled muhimode fiber amplifier 显示文摘 | KOPLOW J P KLINER D A GOLDBERG L | 2000 | Opt Lett2000，25，7： | 1 |
| 11 | Messy genetic algorithms:motiv-Tion,analysis,and first results显示文摘 | Korb K Deb | 1989 | Complex System1989，，3： | 1 |
| 12 | Selective repression by Fis and H-NS at the Escherichia coli dps promoter 显示文摘 | Grainger D C Goldberg M D Lee D J | 2008 | Mol Microbiol2008，68，6： | 1 |
| 13 | Transfer of biologically im portent molecules between cells through gap junction channels 显示文摘 | Alexander D B Goldberg G S | 2003 | Curr Med Chem2003，10，19： | 1 |
| 14 | Linkage problems,distribution estimate, and Bayesian network 显示文摘 | Pelikan M Goldberg D E and Cantu-Paz E | 2000 | Evolutionary Computation2000，8，3： | 1 |
| 15 | Classifier Systems and Genetic Algorithms显示文摘 | Booker L B Goldberg D E Holland J H | 1989 | Artificial Intelligence1989，40，： | 1 |
| 16 | Reanalysis of the Harvard six cities study and the American Cancer Society study of particulate air pollution and mortality显示文摘 | Krewski D Burnett RR Goldberg MS | 2000 | Res Rep Health Eff Inst2000，，： | 1 |
| 17 | Suppression of breast cancer invasion and migration by indole-3-carbinol:associated with up-regulation of BRCA1 and E-cadherin/catenin complexes显示文摘 | MengQ Qi M Chen DZ Yuan R Goldberg I D Rosen E M Auborn K Fan S J | 2000 | J Mol Med2000，78，3： | 1 |
| 18 | Heave compensation and formation strength evaluation from downhole acceleration measurements while coring显示文摘 | G Guerin D Goldberg | 2002 | Geo-Mar Lett2002，22，： | 1 |
| 19 | Using collaborative filtering to weave an information tapestry显示文摘 | Goldberg D Nichols D Oki B M | 1992 | Communications of the Association for Computing Machinery1992，35，12： | 1 |
| 20 | Sonic waveform attenuation in gas hydrate bearing sediments from the Mallik 2L-38 research well, Mackenzie Delta, Canada 显示文摘 | Guerin G Goldberg D | 2002 | Journal of Geophysical Research2002，107，5： | 1 |
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