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| 1 | Aging:A mitochondrial DNA perspective,critical analysis and an update显示文摘The mitochondrial theory of aging, a mainstream theory of aging which once included accumulation of mitochondrial DNA(mt DNA) damage by reactive oxygen species(ROS) as its cornerstone, has been increasingly losing ground and is undergoing extensive revision due to its inability to explain a growing body of emerging data. Concurrently, the notion of the central role for mtDNA in the aging process is being met with increased skepticism. Our progress in understanding the processes of mtDNA maintenance, repair, damage, and degradation in response to damage has largely refuted the view of mt DNA as being particularly susceptible to ROS-mediated mutagenesis due to its lack of 'protective' histones and reduced complement of available DNA repair pathways. Recent research on mitochondrial ROS production has led to the appreciation that mitochondria, even in vitro, produce much less ROS than previously thought, automatically leading to a decreased expectation of physiologically achievable levels of mtDNA damage. New evidence suggests that both experimentally induced oxidative stress and radiation therapy result in very low levels of mtDNA mutagenesis. Recent advances provide evidence against the existence of the 'vicious' cycle of mtDNA damage and ROS production. Meta-studies reveal no longevity benefit of increased antioxidant defenses. Simultaneously, exciting new observations from both comparative biology and experimental systems indicate that increased ROS production and oxidative damage to cellular macromolecules, including mtDNA, can be associated with extended longevity. A novel paradigm suggests that increased ROS production in aging may be the result of adaptive signaling rather than a detrimental byproduct of normal respiration that drives aging. Here, we review issues pertaining to the role of mtDNA in aging. | Inna N Shokolenko Glenn L Wilson Mikhail F Alexeyev | 2014 | World Journal of Experimental Medicine2014，4，4： | 6 |
| 2 | B lymphocytes regulate airway granulocytic inflammation and cytokine production in a murine model of fungal allergic asthma显示文摘到真菌的促进感受性经常导致是特别地困难的临床上设法的气喘的一种严重形式,导致在这些病人的增加的病态和住院。尽管 B 淋巴细胞可能通过 IgE 的生产加重气喘症状,这些房间可能也在对吸入的真菌的保护的反应是重要的。通过 cytokine 版本和 T 房间相互作用,这些淋巴细胞可能也影响航线墙纤维变性的发展和维护。J H −/− 老鼠为抗体的重链部件缺乏 JH 基因,它为 B 房间功能和幸存是批评的。这些动物在很多有免疫力的回答便于 B 淋巴细胞的角色的说明;然而, J H −/− 老鼠没被用来学习真菌的过敏症。在这研究,我们用曲霉属菌 fumigatus 检验了 B 淋巴细胞的角色模仿被环境真菌的暴露触发的人的航线疾病的鼠科的真菌的高空过敏症模型。我们在敏化的野类型的 BALB/c 和 J 暴露于的 H −/− 老鼠重复了真菌的暴露并且没在大航线附近在航线 hyperresponsiveness,全面肺的发炎或骨胶原免职发现差别。然而, Th2 类型 cytokines IL-4 和 IL-13 的层次显著地在 J 相对 BALB/c 控制的 H −/− 鼠标。由对比,煽动性的 cytokines IL-17A 和 IL-6 的层次显著地在 J H −/− 动物,并且有显著地更柔韧的航线嗜曙红血球过多和 neutrophilia 比在控制动物。一起拿,这些调查结果表明淋巴细胞帮助在肺的分隔空间调整 granulocytic 回答到真菌的暴露的那 B。 | Sumit Ghosh Scott A Hoselton Scott V Asbach Breanne N Steffan Steve B Wanjara Glenn P Dorsam Jane M Schuh | 2015 | Cellular & Molecular Immunology2015，12，2： | 2 |
| 3 | Purification and characteriza-tion of an extracellular Mn(Ⅱ)-dependenperoxidasefrom the lignindegading basidiomycetes,Phancero-chaete chrysosporium显示文摘 | Glenn J K Gold M N | 1985 | Aich biochembiophys1985，242，： | 1 |
| 4 | Isolating microsatellite DNA loci 显示文摘 | GLENN T C SCHABLE N A | 2005 | Methods in Enzymology2005，395，： | 1 |
| 5 | Pyrolysis of inulin,glucose,and fructose显示文摘 | GLENN R P GEOFFREY N R | 1993 | Carbohyd Res1993，24，2： | 1 |
| 6 | Development of a two - sided piezoelectric rotary ultrasonic motor for high torque 显示文摘 | Glenn T Hagood N | 1997 | SPIE1997，3041，： | 1 |
| 7 | The human papillomavirus (HPV) vaccine and cervical cancer: uptake and next steps显示文摘 | Sheinfeld Gorin S N Glenn B A Perkins R B | 2011 | Adv Ther2011，28，8： | 1 |
| 8 | Analysis of LiDAR-derived Topographic Information for Characterizing and Differentiating Landslide Morphology and Activity显示文摘 | Glenn N F Streutker D R Chadwick D J | 2006 | Geonmrphology2006，73，12： | 1 |
| 9 | Purification and characterization of an extracellular Mn (11)-dependenperoxidase from the lignin-degading basidiomycetes, phancerochaete chrysosporium显示文摘 | Glenn J K Gold M N | 1985 | Aich Biochem1985，242，： | 1 |
| 10 | Sildenafil citrate (Viagr/t)impairs fertilization and early embryo develop- ment in mice 显示文摘 | Glenn DR McClure N Cosby SL | 2009 | Fertil Steril2009，91，3： | 1 |
| 11 | The Contribution of Marriage to the Psychological Well-being of Males and Females显示文摘 | Glenn N D | 1975 | Journal of Marriage and the Family1975，37，3： | 1 |
| 12 | Choice of opioid supplementation for day-case rigid bronchoscopy:a randomized placebo-controlled comparison of a bolus of remifentanil and alfentanil显示文摘 | Neil M Agnew Ngukhoon H Tan Nigel D.A Scawn Stephen H Pennefather Glenn N Russell | 2003 | Journal of Cardiothoracic and Vascular Anesthesia2003，，3： | 1 |
| 13 | Purification and characterization of an extracellular Mn( Ⅱ ) -dependent peroxidase from the lignindegading basidiomycetes, Phancerochaete chrysosporium 显示文摘 | Glenn J K Gold M N | 1985 | Aich Biochem Biophys1985，242，： | 1 |
| 14 | Analysis of LiDAR-derived topographic information for characterizing and differentiating landslide morphology and activity显示文摘 | Glenn N F Streutker D R Chadwick D J | | 0，，01： | 1 |
| 15 | Sildenafil cit-rate improves sperm motility but causes a premature acrosome reaction in vitro 显示文摘 | Glenn DR McVicar CM McClure N | 2007 | Fertil Steril2007，87，5： | 1 |
| 16 | Highly enantioselective, catalyticconjugate addition of cyanide to unsaturated imides 显示文摘 | Sammis Glenn M J Eric N | 2003 | Journal ofthe American Chemical Society2003，125，15： | 1 |
| 17 | Teaching neuroimages: infant with glutaric aciduria type 1 presenting with infantile spasms and hypsarrhythmia显示文摘 | Young-Lin N Shalev S Glenn OA | 2013 | Neurology2013，81，24： | 1 |
| 18 | The use of geostatistics in relating soil moisture to RADARSAT-1 SAR data obtained over the Great Basin,Nevada,USA显示文摘 | Glenn N F Carr G R | 2003 | Computers & Geosciences2003，29，： | 1 |
| 19 | Vasospasm probability index: a combination of transcranial doppler velocities, cerebral blood flow, and clinical risk factors to predict cerebral vasospasm after aneurysmal sabaracbnoid hemorrhage 显示文摘 | Gonzalez N R Boscardin W J Glenn T | 2007 | J Neurosurg2007，107，6： | 1 |
| 20 | Heterogeneous oxidation of mercury in simulated post combustion conditions显示文摘 | Glenn A N Hongqun Y Robert C B | 2003 | Fuel2003，82，： | 1 |
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