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| 1 | Hemozoin triggers tumor necrosis factor alpha-mediated release of lysozyme by human adherent monocytes:new evidences on leukocyte degranulation in P.falciparum malaria显示文摘Objective:Avidly phagocytosed hemozoin(malarial pigment) alters several functions of human monocytes and stimulates generation of several cytokines.Recently,we showed that phagocytosis of hemozoin by human monocytes increases expression and activity of matrix metalloproteinase-9,a proteolytic enzyme available in specific gelatinase granules,which contain several enzymes including lysozyme.Present work investigated active lysozyme release after phagocytosis of hemozoin and its dependence on production of tumor necrosis factor alpha. Methods:After phagocytosis of hemozoin,hemozoin-containing trophozoites or control meals(opsonized nonparasitized red blood cells and latex particles),monocyte supematants were monitored for 2 hours,in presence of blocking anti-human tumor necrosis factor alpha antibodies or recombinant human tumor necrosis factor alpha cytokine in selected experiments.Lysozyme release was evaluated by a specific spectrometric assay measuring lysozyme activity after coincubation of cell supematants with suspensions of Mycrococcus Lysodeikticus,while levels of soluble tumor necrosis factor alpha were analyzed by specific enzyme-linked immunodsorbent assay. Results:Levels of lysozyme activity and soluble tumor necrosis factor alpha protein were increased in hemozoin in-or trophozoites-laden monocytes supematants.Phagocytosis per se(control meals) also increased lysozyme release,but levels were significantly lower than those obtained after phagocytosis of hemozoin or trophozoites. Interestingly,all effects on lysozyme release observed after phagocytosis were abrogated by blocking anti-human tumor necrosis factor alpha antibodies,while they were mimicked by recombinant human tumor necrosis factor alpha cytokine.Conclusions:Present work shows that phagocytosis of hemozoin promotes monocyte degranulation and enhances active lysozyme release.The effect requires tumor necrosis factor alpha mediation. | Mauro Prato Giribaldi G Arese P | 2009 | Asian Pacific Journal of Tropical Medicine2009，2，3： | 3 |
| 2 | From control to eradication of malaria:the end of being stuck in second gear?显示文摘More than 2 billion people are at risk of malaria,which primarily affects poor populations in tropical and subtropical areas,including Southern Asia.As malaria incidence has been reduced strongly in some parts of endemic regions by combinations of interventions,including artemisinin-based therapies and insecticide-treated bed nets,a new goal has been established recently by charity foundations which support research on malaria:the worldwide eradication of the pathology.Doing away with control approaches which have been applied for the last 50 years and more focus on elimination objectives will deeply change priorities in the area of malaria treatment,chemoprevention,vector control,vaccine research and health system assessment.In this review,actual knowledge on pathogenesis and pharmacology is discussed,and new drugs, vaccines and insecticides are described. | Khadjavi Amina Giribaldi Giuliana Prato Mauro | 2010 | Asian Pacific Journal of Tropical Medicine2010，3，5： | 2 |
| 3 | Involvement of p38 MAPK in haemozoin-dependent MMP-9 enhancement in hu- man monocytes显示文摘 | Khadjavi A Valente E Giribaldi G | 2013 | Cell Biochem Funct2013，32，1： | 1 |
| 4 | Pro-teomic identification of Reticulocalbin 1 as potential tumormarker in renal cell carcinoma 显示文摘 | GIRIBALDI G BARBERO G MANDIU G | 2013 | Journal of Proteomics2013，91，： | 1 |
| 5 | Mycoplasma contami nation of Plasmodium cultures a case of parasite parasitism显示文摘 | Turrini F Giribaldi G Valente E | 1997 | Parasitol Today1997，13，10： | 1 |
| 6 | A unique galectin signature in human prostate cancer progression suggests galectin-1 as a key target for treatment of advanced disease 显示文摘 | haderach DJ Gentilini LD Giribaldi L | 2013 | Cancer Res2013，73，1： | 1 |
| 7 | Heat-unstable protein removal by different bentonite labels in white wines显示文摘 | LAMBRI M DORDONI R GIRIBALDI M | | 0，，02： | 1 |
| 8 | Analysis of protein changes during grage berry ripening by I DE and MAIJDI-TOF 显示文摘 | Giribaldi M Perugini L Sauvage F X | 2007 | Protecmics2007，7，： | 1 |
| 9 | Effect of two pasteurization methods on the protein content of human milk显示文摘 | Baro C Giribaldi M Arslanoglu S | 2011 | Front Biosci2011，1，3： | 1 |
| 10 | Effect of pH on the protein profile and heat stability of an Italian white wine显示文摘 | Lambri M Dordoni R Giribaldi M | 2013 | Food Research International2013，54，2： | 1 |
| 11 | Naturally occurring anti- band 3 antibodies and red blood cell removal under physiological and pathological conditions显示文摘 | Pantaleo A Giribaldi G Mannu F | 2008 | Autoimmun Rev2008，7，6： | 1 |
| 12 | Proteomic identification of Reticulocalbin 1 as potential tumor marker in renal cell carci- noma显示文摘 | Giribaldi G Barbero G Mandili G | 2013 | Journal of proteomics2013，91，： | 1 |
| 13 | Analysis of protein changes during grape berry ripening by 2-DE and MALDI-TOF显示文摘 | GIRIBALDI M PERUGINI L SAUVAGE F X SCHUBERT A | 2007 | Proteomics2007，7，： | 1 |
| 14 | Effect of two pasteurization methods on the protein content of human milk显示文摘 | Baro C Giribaldi M Arslanoglu S | 2011 | Front Biosci ( Elite Ed )2011，3，： | 1 |
| 15 | Effect of two pasteurization methods on the protein content of human milk显示文摘 | Baro C Giribaldi M Arslanoglu S | 2011 | Front Biosci(Elite Ed)2011，3，： | 1 |
| 16 | Co-ordinated stage-dependent enhancement of Plasmodium faleiparum antioxidant enzymes and heat shock protein expres- sion in parasites growing in oxidatively stressed or G6PD-defi- cient red blood cells显示文摘 | AKIDE-NDUNGE O B TAMBINI E GIRIBALDI G | 2009 | Malaria Journal2009，8，6： | 1 |
| 17 | Phagocytosis of hemozoin enhances matrix metalloproteinase-9 activity and TNF-α production in human monocytes: Role of matrix metalloproteinases in the pathogenesis of falciparum malaria 显示文摘 | Prato M Giribaldi G Polimeni M | 2005 | J Immunol2005，175，10： | 1 |
| 18 | Phagocytosis of haemozoin (malarial pigment) enhances metalloproteinase-9 activity in human adherent monocytes: Role of IL-lbeta and 15-HETE显示文摘 | Prato M Gallo V Giribaldi G | 2008 | Malar J2008，7，： | 1 |
| 19 | Anal- ysis of protein changes during grape berry ripening by 2-DE and MALDI-TOF显示文摘 | GIRIBALDI M PERUGINI I SAUVAGE F X SCHUBERT A | 2007 | Proteomics2007，7，17： | 1 |
| 20 | Galectin - 1 confers immune privilege to haman trophoblast: implications in recurren fetal loss显示文摘 | Ramhorst RE Giribaldi L Fraccaroli L | 2012 | Glycobiology2012，22，10： | 1 |
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