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| 1 | Adenoma and advanced neoplasia detection rates increase from 45 years of age显示文摘BACKGROUND Colonoscopy is considered a valid primary screening tool for colorectal cancer(CRC). The decreasing risk of CRC observed in patients undergoing colonoscopy is correlated with the adenoma detection rate(ADR). Due to the fact that screening programs usually start from the age of 50, very few data are available on the risk of adenoma between 40 and 49 years. However, the incidence of CRC is increasing in young populations and it is not uncommon in routine practice to detect adenomas or even advanced neoplasia during colonoscopy in patients under 50 years.AIM To compare the ADR and advanced neoplasia detection rate(ANDR) according to age in a large series of patients during routine colonoscopy.METHODS All consecutive patients who were scheduled for colonoscopy were included.Exclusion criteria were as follows: patients scheduled for partial colonoscopy or interventional colonoscopy(for stent insertion or stenosis dilation).Colonoscopies were performed in our unit by a team of 30 gastroenterologists in2016. We determined the ADR and ANDR in each age group in the whole population and in the population with an average risk of CRC(excluding patients with personal or family history of advanced adenoma or cancer).RESULTS6027 colonoscopies were performed in patients with a median age of 57 years(range, 15-96). The ADR and ANDR were 28.6% and 9.7%, respectively, in the whole population. When comparing patients aged 40-44(n = 382) and 45-49 years (n = 515), a strong increase in all parameters from 45 years was observed, with the ADR rising from 9.7% in patients aged 40-44 to 21.2% between 45 and 49(P <0.001) and the ANDR increasing from 3.1% in patients aged 40-44 to 6.4% in those aged 45-49 years(P < 0.03). With regard to patients aged 50-54(n = 849), a statistically significant increase in the ADR and ANDR was not observed between patients aged 45-49 and those aged 50-54 years. In the population with an average risk of CRC, the ADR and ANDR were still significantly higher in patients aged 45-49 compared with those aged 40-44 years.CONCLUSION This study shows a significant two-fold increase in the ADR and ANDR in patients aged 45 years and over. | David Karsenti Gaelle Tharsis Pascal Burtin Franck Venezia Gilles Tordjman Agnès Gillet Joelle Samama Karine Nahon-Uzan Philippe Cattan Maryan Cavicchi | 2019 | World Journal of Gastroenterology2019，25，4： | 4 |
| 2 | Agenesis of the gallbladder: A dangerously misdiagnosed malformation显示文摘Isolated agenesis of the gallbladder is a rare anomaly,often asymptomatic. However, one patient out of four presented with right upper abdominal pain, nausea, and fatty food intolerance. The condition is frequently mistaken with an excluded or sclero-atrophic gallbladder, regardless of the imaging modality used. Consequently, AG often leads to unnecessary and potentially dangerous laparoscopic surgery as described in a few case reports over the last10 years. The aim of this study is to clarify the diagnostic and therapeutic approach of this unusual pathology. Two cases seen in our institutions were retrospectively reviewed, together with a review of the American and European literature. During laparoscopy, the absence of normal anatomical structures and the impossibility of pulling on the gallbladder to expose and dissect the triangle of Callot increases the risk of iatrogenic injury to biliary or portal structures. Depending on the experiment of the surgeon in laparoscopic procedure, this has to be taken into account to decide a conversion to laparotomy.A high index of suspicion is necessary when interpreting the radiological images. In case of doubt, a MRJ-cholangiography is mandatory. Because of possible inherited transmission,relatives with a history of biliary symptoms should be investigated. | Nicolas Peloponissios Michel Gillet René Cavin Nermin Halkic | 2005 | World Journal of Gastroenterology2005，11，39： | 4 |
| 3 | Osteogenic differentiation of human bone marrow mesenchymal stem cells in hydrogel containing nacre powder显示文摘 | Alicia Flausse Christel Henrionnet Manuel Dossot Dominique Dumas Sébastien Hupont Astrid Pinzano Didier Mainard Laurent Galois Jacques Magdalou Evelyne Lopez Pierre Gillet Marthe Rousseau | 2013 | J. Biomed. Mater. Res2013，，11： | 2 |
| 4 | The immune response to p53 in breast cancer patients is directed against immunodominant epitopes unrelated to the mutational hot spot显示文摘 | Schlichtholz B Legros Y Gillet D | 1992 | Cancer Res1992，52，22： | 1 |
| 5 | Phase transitions in yttrium oxide at high pressure studied by Raman spectroscopy显示文摘 | HUSSON E PROUST C GILLET P | 1999 | Materials Research Bulletin1999，34，： | 1 |
| 6 | Immediate and midterm complications of sclerotherapy: report of a prospective muhicenter registry of 1 2, 173 sclerotherapy sessions 显示文摘 | Guex JJ Allaert FA Gillet JL | 2005 | rmatol Surg2005，31，： | 1 |
| 7 | Raman spectroscopic studies of carbonates part I:High-pressure and high-temperature behaviour of calcite,magnesite,dolomite and aragonite显示文摘 | Philippe Gillet Claudine Biellmann Bruno Reynard | 1993 | Physics and Chemistry of Minerals1993，20，1： | 1 |
| 8 | The ben- zophenanthridine alkaloids fagaronine induces erythroleukemic cell differentiation by Gene activation 显示文摘 | DUPONT C COUILLEROT E GILLET R | 2005 | Planta Meal2005，71，6： | 1 |
| 9 | Annexin 1 expression and phosphorylation are upregulated during liver regeneration and transformation in antithrombin Ⅲ SV40 T large antigen transgenic mice显示文摘 | Gillet R Bennoun M | 2000 | Hepatology2000，31，2： | 1 |
| 10 | Mechanisms of multidrug resist- ance in cancer 显示文摘 | Gillet JP Gottesman MM | 2010 | Methods Mol Biol2010，596，： | 1 |
| 11 | Regu- lation and expression of the ATP-binding cassette transporter ABCG2 in human embryonic stem ceils显示文摘 | Padmanabhan R Chen KG Gillet JP | 2012 | Stem Cells2012，30，10： | 1 |
| 12 | Vulnerability of desert biological soil crusts to wind erosion: The influences of crust development, soil texture, and disturbance 显示文摘 | Belnap J Gillete DA | 1998 | Journal of Arid Environment1998，39，： | 1 |
| 13 | Adhesion characterization of titanium and titanium nitride thin coatings on metals using the scratch test显示文摘 | Nsongo T Gillet M | 1995 | International Journal of Adhesion and Adhesives1995，15，3： | 1 |
| 14 | The benzophenanthridine alkaloid fagaronine induces erythroleukemic cell differentiation by gene activation显示文摘 | Upont Claude Couillerot Eric Gillet Reynald | 2005 | Planta Med2005，71，： | 1 |
| 15 | The effect of nitrate and ammonium concentrations on growth and alkaloid accumulation of Atropa belladonna hairy roots显示文摘 | Bensaddek L Gillet F Faucedo J E N | 2001 | J Biotechnol2001，85，： | 1 |
| 16 | Endodontic biofilms and secondary infection of total hip arthroplasty显示文摘 | Goffart J Gillet P | | 0，，： | 1 |
| 17 | Non-anti-mitotic concentrations of taxol reduce breast cancer cell invasiveness显示文摘 | Tran TA Gillet L Roger S | 2009 | Biochemical and Biophysical Research Communications2009，379，2： | 1 |
| 18 | Mechanisms of postprandial hyperglycemia in liver transplant recipients: comparison of liver transplant patients with kidney transplant patients and healthy controls 显示文摘 | Schneiter P Gillet M Chiolero R | 2000 | Diabetes Metab2000，26，1： | 1 |
| 19 | Molecular mechanisms of mammalian global genome nucleotide excision repair显示文摘 | Gillet LC Schrer OD | 2006 | ChemRev2006，106，2： | 1 |
| 20 | The core 2 -1, 6-N-acetylglucosaminyltransferase-M encoded by bovine herpesvirus 4 is not essential for virus replication despite contributing to post-translational modifications of structural proteins显示文摘 | Markine-Goriaynoff N Gillet L Karlsen O A | 2004 | J Gen Virol2004，85，： | 1 |
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