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| 1 | Proteomic Analysis Shows Constitutive Secretion of MIF and p53-associated Activity of COX-2-/-Lung Fibroblasts显示文摘The differential expression of two closelyassociated cyclooxygenase isozymes, COX-1 and COX-2, exhibited functions beyond eicosanoid metabolism. We hypothesized that COX-1 or COX-2 knockout lung ?broblasts may display altered protein pro?les which may allow us to further differentiate the functional roles of these isozymes at the molecular level. Proteomic analysis shows constitutive production of macrophage migration inhibitory factor(MIF) in lung ?broblasts derived from COX-2^(-/-)but not wild-type(WT) or COX-1à/àmice. MIF was spontaneously released in high levels into the extracellular milieu of COX2^(-/-) ?broblasts seemingly from the preformed intracellular stores, with no change in the basal gene expression of MIF. The secretion and regulation of MIF in COX-2^(-/-)was ‘‘prostaglandin-independent.' GO analysis showed thatconcurrent with upregulation of MIF, there is a signi?cant surge in expression of genes related to?broblast growth, FK506 binding proteins, and isomerase activity in COX-2^(-/-)cells. Furthermore,COX-2^(-/-)?broblasts also exhibit a signi?cant increase in transcriptional activity of various regulators, antagonists, and co-modulators of p53, as well as in the expression of oncogenes and related transcripts. Integrative Oncogenomics Cancer Browser(Intro Gen) analysis shows downregulation of COX-2 and ampli?cation of MIF and/or p53 activity during development of glioblastomas,ependymoma, and colon adenomas. These data indicate the functional role of the MIF-COXp53 axis in in?ammation and cancer at the genomic and proteomic levels in COX-2-ablated cells.This systematic analysis not only shows the proin?ammatory state but also unveils a molecular signature of a pro-oncogenic state of COX-1 in COX-2 ablated cells. | Mandar Dave Abul B.M.M.K.Islam Roderick V.Jensen Agueda Rostagno Jorge Ghiso Ashok R.Amin | 2017 | Genomics, Proteomics & Bioinformatics2017，15，6： | 2 |
| 2 | Stroke in Icelandic patients with hereditary amyloid angiopathy is related to a mutation in the Cystatin C gene, an inhibitor of cysteine proteases 显示文摘 | Levy E Lopez-Otin C Ghiso J | 1989 | J EXP MED1989，169，5： | 1 |
| 3 | YAP activation is an early event and a potential therapeutic target in liver can- cer development 显示文摘 | PERRA A KOWALIK M A GHISO E | 2014 | J Hepatol2014，61，5： | 1 |
| 4 | Unifying features of systemic and cerebral amyloidosis显示文摘 | Ghiso J Wisniewski T Frangione B | 1994 | Mol Neurobiol1994，8，1： | 1 |
| 5 | An assessment of the antioxidant and the antiamyloidogenic properties of melatonin: implications for Alzheimer’s disease显示文摘 | M. A. Pappolla Y. -J. Chyan B. Poeggeler B. Frangione G. Wilson J. Ghiso R. J. Reiter | | Journal of Neural Transmission0，，： | 1 |
| 6 | Cerebral amyloid angiopathy and Alzheimer's disease显示文摘 | Jorge Ghiso Yasushi Tomidokoro Tamas Revesz | 2010 | Hirosaki Med J2010，，： | 1 |
| 7 | Unmanipulated haploidentical bone marrow transplantation and post- transplant cyclophosphamide for hematologic malignanices following a myeloablative conditioning:an update显示文摘 | Bacigalupo A Dominietto A Ghiso A | 2015 | Bone Marrow Transplant2015，502，： | 1 |
| 8 | Peptides homologous to the amyloid protein of Alzheimer's disease containing a glutamine for glutamic acid substitution have accelerated amyloid fibril formation显示文摘 | Wisniewski T Ghiso J Frangione B | 1991 | Biochem Bio-phys Res Commun1991，179，3： | 1 |
| 9 | Cerebral amyloid angiopathies: a pathologic, biochemical, and genetic view显示文摘 | Revesz T Ghiso J Lashley T | 2003 | J Neuropathol Exp Neurolj2003，62，9： | 1 |
| 10 | Production of the Alzheimer amyloid beta protein by normal proteolytic processing显示文摘 | Shoji M Golde TE Ghiso J | 1992 | Science1992，258，： | 1 |
| 11 | Brain neprilysin activity and susceptibility to transgene-induced Alzheimer amyloidosis显示文摘 | Troy L. Carter Steve Pedrini Jorge Ghiso Michelle E. Ehrlich Sam Gandy | 2005 | Neuroscience Letters2005，，3： | 1 |
| 12 | Stroke in Icelandic patients with hereditary amyloid angiopathy is related to a mutation in the cystatin C gene, an inhibitor of eysteine proteases显示文摘 | Levy E Lopez-Otin C Ghiso J | 1989 | J Exp Med1989，169，： | 1 |
| 13 | Amyloidosis and Alzheimer's disease显示文摘 | Frangione B | 2002 | Adv Drug Deliv Rev2002，54，12： | 1 |
| 14 | Activation of HER family members in gastric carcinoma cells mediates resistance to MET inhibition显示文摘 | Corso S Ghiso E Cepero V | 2010 | Molecular Cancer2010，9，： | 1 |
| 15 | Suppression ofhypoxiaassociated vascluar endothelial growth factor gene exprssion by nitric oxide via cGMP显示文摘 | Ghiso N Rohan RM Amano S | 1999 | IOVS1999，40，6： | 1 |
| 16 | Suppression of hypoxia-asso- ciated vascular endothelial growth factor gene expression by nitric ox- ide via cGMP显示文摘 | Ghiso N Rohan RM Amano S | 1999 | Inves Ophthalmol Vis Sci1999，40，6： | 1 |
| 17 | YAP activation is an early event and a potential therapeutic target in liver cancer development显示文摘 | Perra A Kowalik MA Ghiso E | 2014 | J Hepatol2014，61，5： | 1 |
| 18 | Unifying features of systemic and cerebral amyloidosis 显示文摘 | Ghiso J Wisniewski T Frangione B | 1994 | Mol NeuroNol1994，8，1： | 1 |
| 19 | Stroke in Icelandicpatients with hereditary amyloid angiopathy is related to a mutation in the cystatin C gene, an inhibitor of cysteine proteases显示文摘 | Levy E Lopez-Otin C Ghiso J | 1989 | J Exp Med1989，169，5： | 1 |
| 20 | Inhibition of FAK signaling activated by urokinase receptor induces dormancy in human carcinoma cells in vivo显示文摘 | Aguirre Ghiso JA | 2002 | Oncogene2002，21，16： | 1 |
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