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| 1 | Preemptive mechanical ventilation can block progressive acute lung injury显示文摘Mortality from acute respiratory distress syndrome(ARDS) remains unacceptable, approaching 45% in certain high-risk patient populations. Treating fulminant ARDS is currently relegated to supportive care measures only. Thus, the best treatment for ARDS may lie with preventing this syndrome from ever occurring. Clinical studies were examined to determine why ARDS has remained resistant to treatment over the past several decades. In addition, both basic science and clinical studies were examined to determine the impact that early, protective mechanical ventilation may have on preventing the development of ARDS in at-risk patients. Fulminant ARDS is highly resistant to both pharmacologic treatment and methods of mechanical ventilation. However, ARDS is a progressive disease with an early treatment window that can be exploited. In particular, protective mechanical ventilation initiated before the onset of lung injury can prevent the progression to ARDS. Airway pressure release ventilation(APRV) is a novel mechanical ventilation strategy for delivering a protective breath that has been shown to block progressive acute lung injury(ALI) and prevent ALI from progressing to ARDS. ARDS mortality currently remains as high as 45% in some studies. As ARDS is a progressive disease, the key to treatment lies with preventing the disease from ever occurring while it remains subclinical. Early protective mechanical ventilation with APRV appears to offer substantial benefit in this regard and may be the prophylactic treatment of choice for preventing ARDS. | Benjamin Sadowitz Sumeet Jain Michaela Kollisch-Singule Joshua Satalin Penny Andrews Nader Habashi Louis A Gatto Gary Nieman | 2016 | World Journal of Critical Care Medicine2016，5，1： | 9 |
| 2 | Robust speed and torque estimation in electrical drives by second -order sliding modes显示文摘 | Bartolini G Damiano A Gatto G | 2003 | IEEE Transactions on Control Systems Technology2003，11，1： | 2 |
| 3 | Unlaerallaminectomy for bi-lateral decompression of lumbar spinal stenosis:a prospective sturywith conserva- tively treated patients 显示文摘 | Mariconda M Fava R Gatto A | 2002 | J Spinal Disord Tech2002，1，： | 1 |
| 4 | Impact strength of nogueira-pecawood on different moisture conditions显示文摘 | Beltrame R Mattos B D Gatto D A | 2012 | Ciencia Rural2012，42，9： | 1 |
| 5 | Photodvnam ic therapy in thetreatm ent of chronic periodontitis : a systematic review and m eta-ana lv s is 显示文摘 | Sgolastra F P etrucci A Gatto R | | Lasers Med S c i0，28，2： | 1 |
| 6 | Separate and combined effects of marijuana and alcohol on mood,equilibrium and simulated driving显示文摘 | Liguori A Gatto CP Jarrett DB | 2002 | Psychopharmacology(Berl)2002，63，： | 1 |
| 7 | Effectiveness of systemic amoxicillin/metronidazole as an adjunctive therapy to filll- mouth scaling and root plmling in the treatment of ag- gressive periodontitis: A systematic review and meta-analy- sis显示文摘 | Sgolastra F Petnlcci A Gatto R | 2012 | J Periodontol2012，83，6： | 1 |
| 8 | Epstein-Barr virus latent membrane protein 1 trans-activates miR-155 transcription through the NF-kappaB pathway显示文摘 | Gatto G Rossi A Rossi D | | 0，，20： | 1 |
| 9 | Lunginjury induced by sepsis : lessons learned from largeanimal models and future directories for treatment 显示文摘 | SADOWITZ B ROY S GATTO L A | 2011 | Expert Rev Anti Infect Ther2011，9，12： | 1 |
| 10 | Occurrence of depression and anxiety before Parkinson′s disease显示文摘 | Jacob EL Gatto NM Thompson A | 2010 | Parkinsonism Relat Disord2010，16，9： | 1 |
| 11 | Path Dependent Options:Buy at the Low, Sell at the High显示文摘 | Goldman M B Sosin H B and Gatto M A | 1979 | Journal of finance1979，34，： | 1 |
| 12 | Path dependent options: buy at the low, sell at the high显示文摘 | GOLDMAN M B SOSIN H B GATTO M A | 1979 | Journal of Finance1979，34，5： | 1 |
| 13 | Path dependent options:'Buy at the low, Sell at the High' 显示文摘 | Goldman B Sosin H Gatto M A | 1979 | Journal of Finance1979，，34： | 1 |
| 14 | ZrO 2-Nafion composite membranes for polymer electrolyte fuel cells(PEFCs)at intermediate temperature显示文摘 | Sacca A Gatto I Carbone A | 2006 | Journal of Power Sources2006，163，1： | 1 |
| 15 | Valvular heart disease and the use of dopamine agonists for Parkinson' s disease 显示文摘 | Zanettini R Antonini A Gatto G | 2007 | N Engl J Med2007，356，： | 1 |
| 16 | Evaluation of a three degree-of-freedom test rig for stability derivative estima- tion显示文摘 | GATTO A LOWENBERG M H | 2006 | Journal of Aircraft2006，43，6： | 1 |
| 17 | Exogenous surfactant and positire end-expiratory pressure in the treatment of endntoxin-induced lung injury显示文摘 | Lutz CJ Picone A Gatto LA | 1998 | Crit Care Med1998，26，8： | 1 |
| 18 | High- speed turning experiments on metal matrix composites 显示文摘 | L Luliano L Settineri A Gatto | 1998 | Composites Part A1998，29，： | 1 |
| 19 | Nephritogenic-antinephritogenic antibody network in lupus glomerulonephritis显示文摘 | Doria A Gatto M | | 0，，14： | 1 |
| 20 | Effectiveness of systemic amoxicillin/metronidazole asan adjunctive therapy to full-mouth- scaling and root planing in the treatment of aggressive periodonti- tis: a systematic review and meta-analysis显示文摘 | Sgolastra F Petrucci A Gatto R | 2012 | J Periodontol2012，83，6： | 1 |
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