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| 1 | 大气二氧化氮与每日总死亡率、心血管和呼吸系统疾病死亡率的短期关联:398个城市的多中心分析显示文摘目的:采用统一的分析方案,评估全球多个国家/地区的二氧化氮(NO_(2))与总死亡率、心血管和呼吸系统疾病死亡率之间的短期关联。研究设计:采用两阶段的时间序列分析方法、过度离散的广义线性模型和多水平meta分析。研究地点:22个低到高收入国家/地区的398个城市。主要结局指标:1973—2018年逐日总死亡人数(6280万人)、心血管疾病死亡人数(1970万人)和呼吸系统疾病死亡人数(550万人)。结果:平均而言,NO_(2)浓度在滞后1天(前1天)每增加10μg/m^(3),会导致总死亡率、心血管和呼吸系统疾病死亡率分别增加0.46%(95%可信区间0.36%~0.57%)、0.37%(0.22%~0.51%)、0.47%(0.21%~0.72%)。在对共污染物(PM_(10)、PM_(2.5)、臭氧、二氧化硫和一氧化碳)进行调整后,这些关联仍然很稳定。所有3种死因的暴露-反应曲线几乎是线性的,没有明显的阈值。在398个城市中,可归因于高过假定零水平的NO_(2)浓度造成的死亡比例为1.23%(95%可信区间0.96%~1.51%)。结论:这项多中心研究提供了关于NO_(2)短期暴露与总死亡率、心血管和呼吸系统死亡风险之间的独立和线性关联的关键证据,说明通过加强NO_(2)的控制和监管限制标准,可获得人群水平的健康收益。 | 孟夏 刘聪(校) 陈仁杰 郑湃(译) 阚海东(校) Francesco Sera Ana Vicedo-Cabrera Ai Milojevic Maria Guo Yuming Tong Shilu Micheline de Sousa Zanotti Stagliorio Coelh Paulo Hilario Nascimento Saldiva Eric Lavigne Patricia Matus Correa Nicolas Valdes Ortega Samuel Osorio Garcia Jan Kysely Ales Urban Hans Orru Marek Maasikmets Jouni J K Jaakkola Niilo Ryti Veronika Huber Alexandra Schneider Klea Katsouyanni Antonis Analitis Masahiro Hashizume Yasushi Honda Chris Fook Sheng Ng Baltazar Nunes João Paulo Teixeira Iulian Horia Holobaca Simona Fratianni Ho Kim Aurelio Tobias Carmeníniguez Bertil Forsberg ChristoferÅström Martina S Ragettli Yue-Liang Leon Guo Shih-Chun Pan Shanshan Li Michelle L Bell Antonella Zanobetti Joel Schwartz Tangchun Wu Antonio Gasparrini | 2021 | 英国医学杂志中文版2021，24，8： | 7 |
| 2 | Distributed lag non-linear models显示文摘 | Gasparrini A Armstrong B Kenward M G | 2010 | Statistics in Medicine2010，29，： | 1 |
| 3 | Distributed lag non-linear models显示文摘 | Gasparrini A Armstrong B Kenward M | 2010 | Stat Med2010，29，21： | 1 |
| 4 | Strawberry Enriched Diet Counteracts Oxidative Stress in Plasma and Liver of Old Rats and Improves Mitochondrial Functionality显示文摘 | Francesca Giampieri Jose M Alvarez-Suarez Luca Mazzoni Massimiliano Gasparrini Tamara Y Forbes-Hernandez Bruno Mezzetti Maurizio Battino | 2013 | Free Radical Biology and Medicine2013，，： | 1 |
| 5 | Molecular recognition by a silica-bound fullerene derivative显示文摘 | GASPARRINI F MAGGINI M | 1997 | J Am ChemSoc1997，119，32： | 1 |
| 6 | Isolation and structure elueidation offournewtriterpenoid estersaponins from fruits of Pittosporum tobira AIT显示文摘 | Acquariea ID Cfistina M D Gasparrini F | 2002 | Tetrahedion2002，58，10： | 1 |
| 7 | Massive hydrothermal dolomites in the southwestern Cantabrian Zone(Spain)and their relation to the Late Variscan evolution显示文摘 | Gasparrini M Bechstadt T Booni M | 2006 | Marine and Petroleum Geology2006，23，： | 1 |
| 8 | Massive hydrothermal dolomites in the southwestern Cantabrian Zone ( Spain ) and their relation to the Late Variscan evolution 显示文摘 | Gasparrini M Beohstadt T Boni M | 2006 | Marine and Petroleum Geology2006，23，： | 1 |
| 9 | Distributed lag non-linear models 显示文摘 | Gasparrini A Armstrong B Kenward M G | 2010 | Statistics in medicine2010，29，21： | 1 |
| 10 | Potential envieonmental hazard in the mining district of southern Iglesiente (S W Sardinia, Italy)显示文摘 | Boni M Costabile S Vivo B D Gasparrini M | 1999 | Journal of Geochemical Exploration1999，67，： | 1 |
| 11 | D~strtbuted lag non - linear models 显示文摘 | Gasparrini A Armstrong B Kenward M | 2010 | Statistics in Medicine2010，29，21： | 1 |
| 12 | Massive hydrothermal dolomites in the southwestern Cantabrian Zone (Spain) and their relation to the Late Variscan evolution显示文摘 | Gasparrini M Bechstadt T Boni M | 2006 | Marine and Petroleum Geology2006，23，： | 1 |
| 13 | Distributed lognon-linear models 显示文摘 | A Gasparrini B Armstrong M G Kenward | 2010 | Statistics in Medicine2010，29，5： | 1 |
| 14 | Enantioselective chromatography on brushtype chiral stationary phases containing totally synthetic selectors Theoretical aspects and practical applications显示文摘 | Gasparrini F Misiti D Pierini M | 1996 | J Chromatogr A1996，724，： | 1 |
| 15 | Attributable risk from distributed lag models显示文摘 | GASPARRINI A LEONE M | 2014 | BMC Med Res Methodol2014，23，： | 1 |
| 16 | Massive hydrothermal dolomites in the southwestern Cantabrian Zone (Spain) and their relation to the Late Variscan evolution显示文摘 | Gasparrini M | 2006 | Marine and Petroleum Geology2006，23，： | 1 |
| 17 | Laparoscopic assisted transvaginal cholecystectomy: single centre preliminary experience显示文摘 | Brescia A L Masoni M Gasparrini | 2013 | The surgeon: journal of the Royal Colleges of Surgeons of Edinburgh and Ireland2013，，1： | 1 |
| 18 | An enzymatic, stereoselective synthesis of (S)-norcoclaurine 显示文摘 | Bonamore A Rovardi I Gasparrini F Baiocco P Barba M Molinaro C Botta B Boffi A Macone A | 2010 | Green Chem2010，12，9： | 1 |
| 19 | Germinal Vesicle Material Is Essential for Nucleus Remodeling after Nuclear Transfer显示文摘 | Shaorong Gao Gasparrini B McGarry M Ferrier T Fletcher J Harkness L Sousa P D Wilmut I | 2002 | Biology of Reproduction2002，67，： | 1 |
| 20 | Massive hydrothermal dolomites in the southwestern Cantabrian Zone(Spain) and their relation to the Late Variscan evolution显示文摘 | Gasparrini M Bechstadt T Boni M | 2006 | Marine and Petroleum Geology2006，23，5： | 1 |
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