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| 1 | Quantitative analysis of conjunctival microvasculature imaged using optical coherence tomography angiography显示文摘Background:The goal was to quantitatively analyze the bulbar conjunctival microvascular density using optical coherence tomography angiography(OCTA)and compare it to the vessel density using functional slit-lamp biomicroscopy(FSLB).Methods:Temporal bulbar conjunctiva of 20 eyes(10 healthy subjects)was imaged using both OCTA and FSLB.Image processing was performed including equalization,de-noising,thresholding,and skeletonization.The vessel density was measured by fractal analysis(box counting,Dbox)and pixel counting(%).Results:Vessel density(Dbox)of the bulbar conjunctiva obtained using OCTA was 1.28±0.01 Dbox,which was significantly lower than the result(1.32±0.01 Dbox,P<0.001)obtained using FSLB.Furthermore,the vessel density(%)obtained using OCTA was 3.31±0.12%,which was also significantly lower than the result(3.69±0.16%,P<0.001)obtained using FSLB.No significant correlations(r ranged from 0.21 to 0.32,P>0.05)between both instruments were found in both vessel density methods(Dbox and percentage).However,in each of the devices,vessel density in Dbox was significantly correlated with the vessel density in percentage(r=1.0 for FSLB and r=0.98 for OCTA,both P<0.001).Conclusion:This study demonstrated that the vessel density of the bulbar conjunctiva obtained using OCTA can be quantified,and the results were not compatible with that obtained using slit-lamp biomicroscopy photography. | Zhiping Liu Hua Wang Hong Jiang Giovana Rosa Gameiro Jianhua Wang | 2019 | Eye and Vision2019，6，1： | 4 |
| 2 | Retinal tissue hypoperfusion in patients with clinical Alzheimer’s disease显示文摘Background:It remains unknow whether retinal tissue perfusion occurs in patients with Alzheimer’s disease.The goal was to determine retinal tissue perfusion in patients with clinical Alzheimer’s disease(CAD).Methods:Twenty-four CAD patients and 19 cognitively normal(CN)age-matched controls were recruited.A retinal function imager(RFI,Optical Imaging Ltd.,Rehovot,Israel)was used to measure the retinal blood flow supplying the macular area of a diameter of 2.5 mm centered on the fovea.Blood flow volumes of arterioles(entering the macular region)and venules(exiting the macular region)of the supplied area were calculated.Macular blood flow was calculated as the average of arteriolar and venular flow volumes.Custom ultra-high-resolution optical coherence tomography(UHR–OCT)was used to calculate macular tissue volume.Automated segmentation software(Orion,Voxeleron LLC,Pleasanton,CA)was used to segment six intra-retinal layers in the 2.5 mm(diameter)area centered on the fovea.The inner retina(containing vessel network),including retinal nerve fiber layer(RNFL),ganglion cell-inner plexiform layer(GCIPL),inner nuclear layer(INL)and outer plexiform layer(OPL),was segmented and tissue volume was calculated.Perfusion was calculated as the flow divided by the tissue volume.Results:The tissue perfusion in CAD patients was 2.58±0.79 nl/s/mm^(3)(mean±standard deviation)and was significantly lower than in CN subjects(3.62±0.44 nl/s/mm^(3),P<0.01),reflecting a decrease of 29%.The flow volume was 2.82±0.92 nl/s in CAD patients,which was 31%lower than in CN subjects(4.09±0.46 nl/s,P<0.01).GCIPL tissue volume was 0.47±0.04 mm^(3) in CAD patients and 6%lower than CN subjects(0.50±0.05 mm^(3),P<0.05).No other significant alterations were found in the intra-retinal layers between CAD and CN participants.Conclusions:This study is the first to show decreased retinal tissue perfusion that may be indicative of diminished tissue metabolic activity in patients with clinical Alzheimer’s disease. | Giovana Rosa Gameiro Hong Jiang Yi Liu Yuqing Deng Xiaoyan Sun Bernardo Nascentes Bernard Baumel Tatjana Rundek Jianhua Wang | 2018 | Eye and Vision2018，5，1： | 2 |
| 3 | Recovery of copper from ammoniacal medium using liquid membranes with LIX54 显示文摘 | LURDES M GAMEIRO F ROSINDA M | 2008 | Separation and Purification Technology2008，63，2： | 1 |
| 4 | Leukopenia and thrombocytopenia induced byetanercept:two case reports and literature review显示文摘 | ValderilioFeijo Azevedo Marilia Barreto Gameiro Silva DeboraKarine Marinello | 2012 | Rev Bras Reumatol2012，52，1： | 1 |
| 5 | Experimentalstudy of the quasi-static and dynamic behavior of cork undercompressive loading显示文摘 | Celina Pires Gameiro Jose Cirne Gerard Gary | 2007 | Journal of Materials Science2007，42，： | 1 |
| 6 | Highly conserved asparagine 82 controls the interaction of Na + with the sodium-coupled neutral amino acid transporter SNAT2 显示文摘 | ZHANG Z GAMEIRO A GREWER C | 2008 | J Biol Chem2008，283，12： | 1 |
| 7 | Assessing infer-tility stress:re-examining the factor structure of the Fertility Problem Inventory显示文摘 | Moura-Romos M Gameiro S Canavarro MC | 2012 | Hum Reprod2012，27，2： | 1 |
| 8 | Changes in the immune system during menopause and aging 显示文摘 | Gameiro C Romao F | 2010 | Front Biosci (Elite Ed)2010，2，： | 1 |
| 9 | Caneer vaccines targeting careinoem-bryonic antigen: state-of-the-art and future promise显示文摘 | Gameiro S R Jammeh M L Hodge J W | 2013 | Expert Rev Vaccines2013，12，5： | 1 |
| 10 | Menopause and aging: chan- ges in the immune system - a review Maturitas 显示文摘 | Gameiro CM Romao F Castelo - Branco C | 2010 | 67 (4) : 316 -3202010，67，4： | 1 |
| 11 | Optimal in vitro fertilization in2020 should reduce treatment burden and enhance care delivery for patients and staff显示文摘 | Gameiro S Boivin J Domar A | 2013 | Fertil Steril2013，100，： | 1 |
| 12 | New insights into the translocation route of enrofloxacin and its metaUoantibiotics显示文摘 | Ribeiro C Lopes S C Gameiro P | 2011 | The Journal of Membrane Biology2011，241，3： | 1 |
| 13 | Glutamate forward and reverse transport: from molecular mechanism to transporter - mediated release after ischemia显示文摘 | Grewer C Gameiro A Zhang Z | 2008 | IUBMB Life2008，60，9： | 1 |
| 14 | Menopause and aging:changes in the immune system--a review显示文摘 | Gameiro CM Romo F Castelo-Branco C | 2010 | Maturitas2010，67，4： | 1 |
| 15 | New insights into the translocation route of enrofloxacin and its metalloantibiotics显示文摘 | Ribeiro C Lopes S C Gameiro P | 2011 | The Journal of Membrane Biology2011，241，3： | 1 |
| 16 | New Insights into the Transloca- tion Route of Enrofloxacin and Its Metalloantibiotics 显示文摘 | Ribeiro C Lopes S C Gameiro P | 2011 | J Mem- brane Biol2011，241，： | 1 |
| 17 | Abscopal Regression of Antigen Disparate Tumors by Antigen Cascade After Systemic Tumor Vac- cination in Combination with Local Tumor Radiation显示文摘 | HodgeJW Sharp HJ Gameiro SR | 2012 | Cancer Biother Radiopharm2012，27，1： | 1 |
| 18 | Comparison of pelvic floor muscle strength evaluations in nulliparous and primiparous women:a prospective study显示文摘 | Gameiro MO Sousa VO Gameiro LF | | 0，，： | 1 |
| 19 | Environmental drivers of phytoplankton distribution and composition in Tagus Estuary,Portugal Estuaine显示文摘 | GAMEIRO G CARTAXANA P BROTAS V | | 0，，1： | 1 |
| 20 | How may stressful experiences contribute to the development of temporomandibular dis- orders?显示文摘 | Gameiro GH da-Silva-Andrade A Nouer DF | 2006 | Clin Oral Investig2006，10，4： | 1 |
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