|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Cetuximab plus FOLFOX6 or FOLFIRI in metastatic colorectal cancer: CECOG trial显示文摘AIM: To investigate efficacy and safety of cetuximab combined with two chemotherapy regimens in patients with unresectable metastatic colorectal cancer (mCRC). METHODS: Randomized patients received cetuximab with 5-fluorouracil (5-FU), folinic acid (FA) and oxaliplatin (FOLFOX) 6 (arm A, n = 74) or 5-FU, FA and irinotecan (FOLFIRI) (arm B, n = 77). KRAS mutation status was determined retrospectively in a subset of tumors (n = 117). RESULTS: No significant difference was found between treatment arms A and B in the progression-free survival (PFS) rate at 9 mo, 45% vs 34%; median PFS, 8.6 mo vs 8.3 mo [hazard ratio (HR) = 1.06]; overall response rate (ORR) 43% vs 45% [odds ratio (OR) = 0.93] and median overall survival (OS), 17.4 mo vs 18.9 mo (HR = 0.98). Patients with KRAS wild-type tumors demonstrated improved PFS (HR = 0.55, P = 0.0051), OS, (HR = 0.62, P = 0.0296) and ORR (53% vs 36%) and in arm A, improved PFS (HR = 0.49, P = 0.0196), OS (HR = 0.48, P = 0.0201) and ORR (56%vs 30%), compared with patients with KRAS mutated tumors. In arm B no significant differences were found in efficacy by KRAS mutation status. Treatment in arms A and B was generally well tolerated. CONCLUSION: This study confirms that combinations of cetuximab with FOLFOX6 or FOLFIRI are effective and significantly improve clinical outcome in KRAS wild-type compared with KRAS mutated mCRC. | Janja Ocvirk Thomas Brodowicz Fritz Wrba Tudor E Ciuleanu Galina Kurteva Semir Beslija Ivan Koza Zsuzsanna Pápai Diethelm Messinger Ugur Yilmaz Zsolt Faluhelyi Suayib Yalcin Demetris Papamichael Miklós Wenczl Zrinka Mrsic-Krmpotic Einat Shacham-Shmueli Damir Vrbanec Regina Esser Werner Scheithauer Christoph C Zie-linski | 2010 | World Journal of Gastroenterology2010，16，25： | 17 |
| 2 | Cystatin C deficiency in human atherosclerosi s and aortic aneurysms显示文摘 | SHI G P GALINA K GRUBB A | 1999 | J Clin Invest1999，104，： | 1 |
| 3 | Cystafin C deficiency increaseelastic lamina degradation and aortic dilatation in apoliprotein Enullmlce显示文摘 | Galina KS Wang B Libby P | 2005 | Circ Res2005，96，3： | 1 |
| 4 | Comparison be- tween Haemophilus parasuis infection in colostrums- deprived and sow-reared piglets显示文摘 | Blanco I Galina P L Oliveira S | 2004 | Vet Mierobiol2004，103，12： | 1 |
| 5 | Quantum chemical modelling of the heterogeneous eleetrontransfer:from qualitative analysis to a polarization curve显示文摘 | Remit B Nazmutdinov Galina A Tsirlina O P | 2000 | Eleetrechimica Aeta2000，45，： | 1 |
| 6 | Dynamin participates in focal extracellular matrix radiation by invasive cells显示文摘 | Massimiliano B Arsenio P Galina B | 2003 | Mol Biol Cell2003，14，10： | 1 |
| 7 | Multi-element, muliLi-medium regional geochemistry in the European Arctic: Element concentration, variation and correlation显示文摘 | Reimann C Galina K de Caritat P | 2001 | Applied Geochemistry2001，16，： | 1 |
| 8 | WBC filtration of whole blood after prolonged storage at ambient temperature by use of an in-line filter collection system显示文摘 | Ellat S Galina P Vered Y | 2002 | TRANSFUSION2002，42，6： | 1 |
| 9 | Habitat availability for the mule deer (Cervidae) population in the relictualoak-pine forest of Baja California Sur, Mexico 显示文摘 | ALVAREZ C S GALLINA S GALINA T P | 1999 | Tropical Zoology1999，12，： | 1 |
| 10 | Detoxication of Water Con- taining I ,I-Dimethylhydrazine by Catalytic Oxidation with Diox- ygen and Hydrogen Peroxide over Cu-and Fe-containing catalysts 显示文摘 | Oxana P P Galina L E Zinfer R I | 2002 | Catalysis Today2002，75，： | 1 |
| 11 | Palladium-catalyzed reaction of aryl halides with ureas 显示文摘 | GALINA A A ALEXEY G S IRINA P B | 2001 | Tetrahedron Lett2001，42，： | 1 |
| 12 | Non-hydrothermal synthesis of copper-zinc-and copper zinc hydrosilicates 显示文摘 | Tamara M Yurieva Galina N Kustova Tatyana P Minyukova | 2001 | Mat Res Innovat2001，5，： | 1 |
| 13 | Mining DNA sequence to predict sites which mutations cause genetic diseases 显示文摘 | Julia P Tatyana M Galina O | 2002 | Knowledge-Based systems2002，15，： | 1 |
| 14 | Detoxication of water containing 1,1-dimethylhydrazine by catalytic oxidation with dioxygen and hydrogen peroxide over Cu- and Fe- containing catalysts显示文摘 | OXANA P PESTUNOVA GALINA L ELIZAROVA ZINFER R ISMAQILOV | 2002 | Catalysis Today2002，75，： | 1 |
| 15 | Epoxy resins modified with reactive low molecular weight siloxanes 显示文摘 | Murias P Maciejewski H Galina H | 2012 | European Polymer Journal2012，48，4： | 1 |
| 16 | Characterization of a resource population of pigs screened for resistance to salmonellosis显示文摘 | Van Diemen P M Kreukniet M B Galina L | 2002 | Vet Immunol Immunopathol2002，88，： | 1 |
| 17 | Cystatin c deficiency increase elastic lamina degradation and aortic dilatation in apoliprotei E-nullmice显示文摘 | Wang B Libby P | 2005 | Circ Res2005，96，3： | 1 |
| 18 | Lung cancerderived bombesin-like peptides down-regulate the generation and function of human dendritic cells显示文摘 | Valeria P Makarenkova Galina V | 2003 | Journal of Neuroimmunology2003，145，： | 1 |
| 19 | Detoxication of water containing 1,1-dimeghyhydrazine by catalytic oxidation with dioxygen and hydroden peroxide over Cu-and Fe-containing catalysts显示文摘 | Oxana P Pesrunov Galina L Elizarova Zinfer R Ismagilov | 2002 | Catalysis Today2002，75，： | 1 |
| 20 | Stratigraphy of Upper Permian and Lower Triassic Strata of the Ziri Area ( Slovenia ) 显示文摘 | JURKOVSEK T K JURKOVSEK B ALJINOVIC D GALINA P | 2011 | Geologija2011，542，： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员