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| 1 | Inhibition of the G9a/GLP histone methyltransferase complex modulates anxiety-related behavior in mice显示文摘Epigenetic 基因规定畸形包括精神分裂症和消沉在各种各样的 neuropsychiatric 混乱,以及在心情和焦虑的规定被含有。另外, epigenetic 机制涉及精神病学的药的行动。当前的 anxiolytic 药有新药的重要缺点,和开发被保证。二蛋白质, G9a (也作为 EHMT2 或 KMT1C 知道) 并且 GLP (象 G9a 一样蛋白质,也作为 EHMT1 或 KMT1D 知道) ,它甲醇化物离氨酸 9 histone H3 (H3K9 ) ,能正在答应 anxiolytic 目标。G9a 的出生后的基因大美人减少焦虑相关的行为,与由过去常对待焦虑(amitriptyline, imipramine 和 paroxetine ) 的一些药的 G9a 层次的减小一致。相反地,在有 GLP haplodeficiency 的老鼠有增加的像焦虑的行为。我们寻求了决定是否 G9a/GLP, UNC0642 和 A-366 的二个药理学禁止者,将有类似的效果到基因 G9a/GLP 不足。当予成年老鼠以时,我们发现有任何一个化合物的 G9a/GLP 抑制减少了像焦虑的行为,与在大脑的减少的 H3K9 methylation 一起。相反,到这些的暴露从胚胎的白天加重(E9.5 ) 9.5 增加了像焦虑的行为直到出生并且减少在成人生活的社会相互作用,当 H3K9 methylation 在在成年老鼠的大脑的正常层次时。这些调查结果增强 G9a/GLP 在大脑开发的不同阶段在像焦虑的行为上有不同效果的基因证据,并且建议指向这条 histone methyltransferase 小径能为开发新 anxiolytic 药是有用的。这些数据也建议在 utero 的抗抑郁剂暴露能在成人生活有否定效果,并且这些效果的进一步的调查被保证。 | Dong-yao WANG Joel KOSOWAN James SAMSOM Laura LEUNG Kai-lai ZHANG Ying-xiang LI Yan XIONG Jian JIN Arturas PETRONIS Gabriel OH Albert H C WONG | 2018 | Acta Pharmacologica Sinica2018，39，5： | 4 |
| 2 | Combined contrast-enhanced power Doppler and real-time sonoelastography performed during EUS, used in the differential diagnosis of focal pancreatic masses (with videos)显示文摘 | Adrian S?ftoiu Sevasti?a Iordache Dan Ionu? Gheonea Carmen Popescu Anca Malo? Florin Gorunescu Tudorel Ciurea Alexandru Iordache Gabriel Lucian Popescu Cǎtǎlin Manea | 2010 | Gastrointestinal Endoscopy2010，，4： | 2 |
| 3 | Pulmonary Vein Denervation Enhances Long-Term Benefit After Circumferential Ablation for Paroxysmal Atrial Fibrillation显示文摘 | Carlo Pappone Vincenzo Santinelli Francesco Manguso Gabriele Vicedomini Filippo Gugliotta Giuseppe Augello Patrizio Mazzone Valter Tortoriello Giovanni Landoni Alberto Zangrillo Christopher Lang Takeshi Tomita Cézar Mesas Elio Mastella Ottavio Alfieri | 2004 | Circulation: Journal of the American Heart Association2004，，3： | 2 |
| 4 | Obesity and cardiometabolic disease risk factors among US adolescents with disabilities显示文摘AIM: To generate prevalence estimates of weight status and cardiometabolic disease risk factors among adolescents with and without disabilities.METHODS: Analysis of the 1999-2010 National Health and Nutrition Examination Survey data was conducted among 12-18 years old with(n = 256) and without disabilities(n = 5020). Mean values of waist circumference, fasting glucose, high-density-lipoprotein cholesterol, triglycerides, systolic and diastolic blood pressure and metabolic syndrome(Met S, ≥ 3 risk factors present) were examined by the following standardized body mass index(BMI) categories for those with and without disabilities; overweight(BMI ≥ 85th- < 95 th percentile for age and sex), obesity(BMI ≥ 95 th percentile) and severe obesity(BMI ≥35 kg/m2). Linear regression models were fit with each cardiometabolic disease risk factor independently as continuous outcomes to show relationships with disability status. RESULTS: Adolescents with disabilities were significantlymore likely to be overweight(49.3%), obese(27.6%) and severely obese(12%) vs their peers without disabilities(33.1%, 17.5% and 3.6%, respectively, P ≤ 0.01 for all). A higher proportion of overweight, obese and severely obese children with disabilities had abnormal SBP, fasting lipids and glucose as well as Met S(18.9% of overweight, 32.3% of obese, 55% of severely obese) vs their peers without disabilities(9.7%, 16.8%, 36.3%, respectively). US adolescents with disabilities are over three times as likely to have Met S(OR = 3.45, 95%CI: 1.08-10.99, P = 0.03) vs their peers with no disabilities.CONCLUSION: Results show that adolescents with disabilities are disproportionately affected by obesity and poor cardiometabolic health vs their peers with no disabilities. Health care professionals should monitor the cardiometabolic health of adolescents with disabilities. | Sarah E Messiah Denise C Vidot Gabriel Somarriba Kanathy Haney Semra Aytur Ruby A Natale Jeffrey P Brosco Kristopher L Arheart | 2015 | World Journal of Diabetes2015，6，1： | 2 |
| 5 | Gate Oxide Damage Reduction Using a Protective Dielectric Layer显示文摘 | Gabriel C T Weling M G | 1994 | IEEE Electron Device Letter1994，15，8： | 1 |
| 6 | Activation of nuclear factor-kappaB in the rat brain after transient focal ischemia 显示文摘 | Gabriel C Justicia C Cammins A | 1999 | Brain Res Mol Brain Res1999，65，1： | 1 |
| 7 | Focal adhesion kinase interacts with the transcriptional coactivator FHL2 and both are overexpressed in epithelial ovarian cancer显示文摘 | Gabriel B Mildenberger S Weisser C W | 2004 | Anticancer Res2004，24，2： | 1 |
| 8 | Targetto Target Interval Versus Probability Effects on P300 in One and Two-Tone Tasks显示文摘 | Croft R J C J Gonsalvez C Gabriel | 2003 | Psychophysiology2003，40，3： | 1 |
| 9 | Activation of the JAK/STATpathway following transient focal cerebral ischmia:signalingthrough jakl and stat3in astrocytes显示文摘 | Justida C Gabriel C Planas AM | 2000 | Glia2000，30，2： | 1 |
| 10 | EDDA/HYNIC-TOC and 18F-FDG in thyroid cancer patients with negative 131I whole body scan显示文摘 | Gabriel M Froehlich F Decristoforo C | 2004 | Eur J Nucl Med Mol Imaging2004，31，3： | 1 |
| 11 | Prediction de 1 intervalle de latence par mesure echographiqueducol uterin dans la rupture premature des membranes avant terme显示文摘 | Gabriel R Morille C Drieux L | 2002 | Gynecol Obstet Fertil2002，30，11： | 1 |
| 12 | The dielectrie properties of biological tissues:I Literature survey显示文摘 | GABRIEL C GABRIEL S CORTHOUT E | 1996 | Physics in Medicine and Biology1996，41，11： | 1 |
| 13 | Comparing effects of three acaricides on Varroa jacobsoni (Acari:Varmidae) and Apis melifera (Hymenoptera:Apidac) using two application techniques显示文摘 | Santigo G P Gabriel O C David M S | 2000 | Florida Entomo-logy2000，83，4： | 1 |
| 14 | Activation of the JAK/STAT pathway following transient focal cerebral ischemia:signaling through Jak1 and Stat3 in astrocytes显示文摘 | Justicia C Gabriel C Planas AM | 2000 | Glia2000，30，3： | 1 |
| 15 | The treatment of unstable thoracic spine fractures with transpedicular screw instrumentation: a 3- year consecutive series显示文摘 | Yue JJ Sossan A Selgrath C Deutsch Lawrence S Wilkens K Testaiuti M Gabriel JP | | 0，，： | 1 |
| 16 | Characterization of African swine fever virus Caucasus isolate in European wild boars显示文摘 | Gabriel C Blome S Malogolovkin A | 2011 | Emerg Infect Dis2011，17，12： | 1 |
| 17 | Target-to-target inter- val versus probability effects on P300 in one-and two-tone tasks 显示文摘 | Croft RJ Gonsalvez C J Gabriel C | 2003 | Psychophysiology2003，40，3： | 1 |
| 18 | Electrochemical degradation of bisphenol A using a flow reactor with a boron-doped diamond anode显示文摘 | Pereira Gabriel F Rocha-Filho Romeu C Bocchi Nerilso | | 0，，： | 1 |
| 19 | Haemostatic profile of reconstituted blood in a proposed 1 : 1 : 1 ratio of packed red blood cells, platelet concentrate and four different plasma preparations 显示文摘 | Ponschab M Schchl H Gabriel C | 2015 | Anaesthesia2015，70，5： | 1 |
| 20 | Synthesis and light gas separations in cross-linked Gemini room tempertature ionic liquid polymer membranes 显示文摘 | Bara J E Hatakeyama E S Gabriel C J | 2008 | J Membrane Science2008，316，12： | 1 |
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