| 1 | 广西梧州市鼻咽癌现场10年的前瞻性研究显示文摘1980年我们在梧州市对20726人进行Epstein-Barr病毒(EBV)壳抗原的IgA类(IgA/VCA)抗体的血清学普查,发现抗体阳性者1136人。当时进行临床和组织学检查共发现18例鼻咽癌病人。经10年追踪观察又发现29例病人,其中1、2期病人25例,早期诊断率达86.2%。血清学普查后在抗体阳性者中逐年追踪,甚至在第10年仍可发现鼻咽癌病人。未追踪的抗体阳性者中发生6例,共计53例,占全部57例(包括抗体阴性者4列)鼻咽癌的93%。因此,根据血清学指标可以在5~10年前预测鼻咽癌发生的可能性,抗体阳性者只要能定期追踪检查就可以在早期发现鼻咽癌。这些结果进一步说明EB病毒与鼻咽癌的发生密切相关。 | 邓洪 曾毅 黄乃琴 黄玉英 黎跃 苏辉民 钟汉桑 练英熙 王培中 G.de The | 1992 | 病毒学报1992，8，1： | 21 |
| 2 | Microbiome in the setting of burn patients:implications for infections and clinical outcomes显示文摘Burn damage can lead to a state of immune dysregulation that facilitates the development of infections in patients.The most deleterious impact of this dysfunction is the loss of the skin’s natural protective barrier.Furthermore,the risk of infection is exacerbated by protracted hospitalization,urinary catheters,endotracheal intubation,inhalation injury,arterial lines and central venous access,among other mainstays of burn care.Currently,infections comprise the leading cause of mortality after major burn injuries,which highlights the improvements observed over the last 50 years in the care provided to burn victims.The need to implement the empirical selection of antibiotic therapy to treat multidrug-resistant bacteria may concomitantly lead to an overall pervasiveness of difficult-to-treat pathogens in burn centres,as well as the propagation of antimicrobial resistance and the ultimate dysregulation of a healthy microbiome.While preliminary studies are examining the variability and evolution of human and mice microbiota,both during the early and late phase burn injury,one must consider that abnormal microbiome conditions could influence the systemic inflammatory response.A better understanding of the changes in the postburn microbiome might be useful to interpret the provenance and subsequent development of infections,as well as to come up with inferences on the prognosis of burn patients.This review aims to summarise the current findings describing the microbiological changes in different organs and systems of burn patients and how these alterations affect the risks of infections,complications,and,ultimately,healing. | Silvia Corcione Tommaso Lupia Francesco G.De Rosa on behalf of Host and Microbiota Interaction Study Group(ESGHAMI)of the European Society of Clinical Microbiology and Infectious Diseases(ESCMID) | 2020 | Burns & Trauma2020，8，1： | 3 |
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